Guardians vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for April 17

Odds updated as of 6:12 p.m.

The Baltimore Orioles are among the MLB teams in action on Thursday, up against the Cleveland Guardians.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Guardians Game Info

• Baltimore Orioles (7-10) vs. Cleveland Guardians (9-8)
• Date: Thursday, April 17, 2025
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and CLEG

Orioles vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-130) | CLE: (+110)
• Spread: BAL: -1.5 (+158) | CLE: +1.5 (-192)
• Total: 8 -- Over: (-115) | Under: (-105)

Orioles vs Guardians Probable Starting Pitchers

Probable Pitchers: Tomoyuki Sugano (Orioles) - 1-1, 3.86 ERA vs Tanner Bibee (Guardians) - 1-1, 4.40 ERA

The Orioles will give the nod to Tomoyuki Sugano (1-1, 3.86 ERA), who is eyeing win No. 2 on the season, and the Guardians will turn to Tanner Bibee (1-1, 4.40 ERA). When Sugano starts, his team is 1-2-0 against the spread this season. Sugano's team won his only start as a favorite this season. The Guardians have a 2-1-0 ATS record in Bibee's three starts that had a set spread. The Guardians were the moneyline underdog for one Bibee start this season -- they won.

Orioles vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (53.2%)

Orioles vs Guardians Moneyline

• Looking at the moneyline for Guardians-Orioles, Cleveland is the underdog at +110, and Baltimore is -130 playing at home.

Orioles vs Guardians Spread

• The Orioles are hosting the Guardians and are favored by 1.5 runs on the spread. The Orioles are +158 to cover the runline, with the Guardians being -192.

Orioles vs Guardians Over/Under

• A total of 8 runs has been set for the Orioles-Guardians game on April 17, with the over available at -115 and the under at -105.

Bet on Baltimore Orioles vs. Cleveland Guardians on FanDuel today!

Orioles vs Guardians Betting Trends

• The Orioles have come away with three wins in the eight contests they have been listed as the favorites in this season.
• Baltimore has a record of 1-2 when favored by -130 or more this year.
• The Orioles and their opponents have gone over the total this season in 11 of their 17 opportunities.
• The Orioles are 6-11-0 against the spread in their 17 games that had a posted line this season.
• The Guardians have won 33.3% of the games this season they were the underdog on the moneyline (3-6).
• Cleveland has a 2-3 record (winning 40% of its games) when playing as a moneyline underdog of +110 or longer.
• The Guardians have combined with opponents to hit the over on the total nine times this season for a 9-8-0 record against the over/under.
• The Guardians have a 7-10-0 record against the spread this season (covering 41.2% of the time).

Orioles Player Leaders

• Cedric Mullins has 16 hits and an OBP of .455 to go with a slugging percentage of .635. All three of those stats lead Baltimore hitters this season. He has a .308 batting average, as well.
• Among all qualifying hitters in MLB, he ranks 27th in batting average, fifth in on-base percentage, and seventh in slugging.
• Mullins has recorded a base hit in two straight games. During his last five outings he is hitting .308 with two doubles, a home run, six walks and three RBI.
• Adley Rutschman is hitting .222 with two doubles, three home runs and seven walks. He's slugging .397 with an on-base percentage of .300.
• His batting average ranks 108th among qualified players, his on-base percentage 113th, and his slugging percentage 90th.
• Ryan O'Hearn has collected 13 base hits, an OBP of .388 and a slugging percentage of .512 this season.
• O'Hearn has picked up a hit in three games in a row. During his last five outings he is batting .286 with a home run, three walks and an RBI.
• Tyler O'Neill has been key for Baltimore with 13 hits, an OBP of .339 plus a slugging percentage of .490.

Guardians Player Leaders

• Steven Kwan has accumulated a .370 on-base percentage and a .463 slugging percentage, both team-best numbers for the Guardians. He's batting .313.
• Including all qualifying hitters in the majors, his batting average places him 22nd, his on-base percentage ranks 42nd, and he is 58th in slugging.
• Jose Ramirez has three doubles, four home runs and six walks while hitting .268. He's slugging .536 with an on-base percentage of .333.
• Including all qualifying hitters, he is 60th in batting average, 76th in on-base percentage and 25th in slugging percentage.
• Kyle Manzardo is batting .185 with a double, a triple, four home runs and 10 walks.
• Carlos Santana is batting .262 with two doubles, two home runs and seven walks.

Orioles vs Guardians Head to Head

• 4/16/2025: 9-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/15/2025: 6-3 CLE (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/4/2024: 9-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/3/2024: 7-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 8-4 CLE (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 10-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/26/2024: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 6/25/2024: 10-8 CLE (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/24/2024: 3-2 CLE (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/24/2023: 5-1 BAL (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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