Giants vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 6:13 a.m.

The MLB's Friday schedule includes the San Francisco Giants facing the Chicago White Sox.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Giants vs White Sox Game Info

• San Francisco Giants (20-30) vs. Chicago White Sox (25-24)
• Date: Friday, May 22, 2026
• Time: 10:15 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and CHSN

Giants vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-108) | CHW: (-108)
• Spread: SF: +1.5 (-196) | CHW: -1.5 (+162)
• Total: 7.5 -- Over: (+110) | Under: (-134)

Giants vs White Sox Probable Starting Pitchers

Probable Pitchers: Trevor McDonald (Giants) - 2-0, 2.37 ERA vs Davis Martin (White Sox) - 6-1, 1.61 ERA

The Giants will call on Trevor McDonald (2-0) against the White Sox and Davis Martin (6-1). McDonald and his team have covered in each of his three starts with a spread this season. This will be McDonald's first start this season with his team as the moneyline favorite. The White Sox have an 8-1-0 record against the spread in Martin's starts. The White Sox have a 7-1 record in Martin's eight starts this season when they were the moneyline underdog.

Giants vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (58.6%)

Giants vs White Sox Moneyline

• Chicago is a -108 underdog on the moneyline, while San Francisco is a -108 favorite at home.

Giants vs White Sox Spread

Giants vs White Sox Over/Under

• A combined run total of 7.5 has been set for Giants-White Sox on May 22, with the over at +110 and the under at -134.

Bet on San Francisco Giants vs. Chicago White Sox on FanDuel today!

Giants vs White Sox Betting Trends

• The Giants have come away with six wins in the 13 contests they have been listed as the favorites in this season.
• This year San Francisco has won seven of 14 games when listed as at least -108 on the moneyline.
• The Giants' games have gone over the total in 22 of their 50 opportunities.
• The Giants are 20-30-0 against the spread in their 50 games that had a posted line this season.
• The White Sox are 21-21 in games they were listed as the moneyline underdog (winning 50% of those games).
• Chicago has gone 21-21 when playing as a moneyline underdog with odds of -108 or longer (50%).
• The White Sox have combined with opponents to go over the total 26 times this season for a 26-21-0 record against the over/under.
• The White Sox are 28-19-0 against the spread this season.

Giants Player Leaders

• Luis Arraez has an OPS of .780, fueled by an OBP of .358 to go with a slugging percentage of .422. He has a .319 batting average, as well.
• He ranks seventh in batting average, 46th in on-base percentage, and 75th in slugging among all qualifying hitters in MLB.
• Arraez will look for his third straight game with a hit in this contest. During his last five outings he is batting .333 with a double, a home run, three walks and two RBIs.
• Casey Schmitt leads San Francisco with 46 hits. He is batting .293 this season and has 18 extra-base hits. He's also slugging .529 with an on-base percentage of .337.
• His batting average is 20th among qualified players, his on-base percentage 73rd, and his slugging percentage 15th.
• Schmitt has picked up a hit in five straight games. In his last five games he is batting .409 with three home runs and four RBIs.
• Jung Hoo Lee is batting .268 with a .385 slugging percentage and 17 RBI this year.
• Lee brings a five-game hitting streak into this game. In his last five games he is hitting .294 with a home run and three RBIs.
• Rafael Devers has six home runs, 20 RBI and a batting average of .246 this season.
• Devers has hit safely in two straight games. During his last five outings he is hitting .273 with three doubles, a home run and two RBIs.

White Sox Player Leaders

• Miguel Vargas has seven doubles, a triple, 11 home runs and 31 walks while batting .237. He's slugging .485 with an on-base percentage of .367.
• He is 111th in batting average, 35th in on-base percentage and 34th in slugging percentage among all qualified batters in the majors.
• Munetaka Murakami's 42 hits and .382 on-base percentage both pace his team. He has a batting average of .244 while slugging .552.
• Including all qualifying hitters, his batting average places him 97th, his on-base percentage ranks 21st, and he is 11th in slugging.
• Colson Montgomery is hitting .223 with eight doubles, 13 home runs and 19 walks.
• Chase Meidroth's .374 slugging percentage leads his team.

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