Padres vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 4:12 a.m.

On Friday in MLB, the San Diego Padres are up against the Athletics.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Padres vs Athletics Game Info

• San Diego Padres (29-20) vs. Athletics (26-24)
• Date: Friday, May 22, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and NBCS-CA

Padres vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-134) | OAK: (+116)
• Spread: SD: -1.5 (+150) | OAK: +1.5 (-182)
• Total: 8 -- Over: (-110) | Under: (-110)

Padres vs Athletics Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Padres) - 3-2, 5.01 ERA vs Jeffrey Springs (Athletics) - 3-4, 3.93 ERA

This contest's pitching matchup is set, as the Padres will send Walker Buehler (3-2) to the mound, while Jeffrey Springs (3-4) will take the ball for the Athletics. When Buehler starts, his team is 6-3-0 against the spread this season. When Buehler starts a game and his team is the favorite on the moneyline, they have a record of 2-2. The Athletics have a 6-4-0 ATS record in Springs' 10 starts with a set spread. The Athletics have a 2-3 record in Springs' five starts this season when they were the moneyline underdog.

Padres vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (54.7%)

Padres vs Athletics Moneyline

• The Padres vs Athletics moneyline has the Padres as a -134 favorite, while the Athletics are a +116 underdog on the road.

Padres vs Athletics Spread

• The Padres are 1.5-run favorites on the runline against the Athletics. The Padres are +150 to cover, while the Athletics are -182 to cover.

Padres vs Athletics Over/Under

• The over/under for Padres-Athletics on May 22 is 8. The over is -110, and the under is -110.

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Padres vs Athletics Betting Trends

• The Padres have won in 14, or 58.3%, of the 24 contests they have been named as odds-on favorites in this year.
• This season, the Padres have come away with a win 10 times in 17 chances when named as a favorite of at least -134 or better on the moneyline.
• The Padres and their opponents have hit the over in 21 of their 49 games with a total this season.
• The Padres have posted a record of 28-21-0 against the spread this season.
• The Athletics have won 56.2% of the games this season they were the underdog on the moneyline (18-14).
• When they have played as a moneyline underdog with odds of +116 or longer, the Athletics have a record of 8-8 (50%).
• The Athletics have combined with their opponents to hit the over on the total 23 times this season for a 23-26-1 record against the over/under.
• The Athletics have a 26-24-0 record ATS this season (covering 52% of the time).

Padres Player Leaders

• Xander Bogaerts leads San Diego in OBP (.318), slugging percentage (.385) and total hits (43) this season. He has a .247 batting average.
• He is 91st in batting average, 102nd in on-base percentage, and 100th in slugging among all qualified batters in the majors.
• Gavin Sheets is hitting .254 with 10 doubles, nine home runs and 16 walks, while slugging .530 with an on-base percentage of .338.
• Manny Machado has collected 30 base hits, an OBP of .272 and a slugging percentage of .331 this season.
• Miguel Andujar has five home runs, 17 RBI and a batting average of .290 this season.

Athletics Player Leaders

• Shea Langeliers has accumulated 59 hits with a .576 slugging percentage, both team-best numbers for the Athletics. He's batting .321 and with an on-base percentage of .394.
• He is sixth in batting average, 10th in on-base percentage and fifth in slugging percentage among all qualifying hitters in the majors.
• Nick Kurtz leads his team with a .438 OBP. He has a batting average of .278 while slugging .483.
• His batting average ranks 40th among all qualified players, his on-base percentage ranks first, and he is 36th in slugging.
• Tyler Soderstrom is batting .196 with 14 doubles, a triple, five home runs and 20 walks.
• Carlos Cortes is hitting .345 with eight doubles, a triple, four home runs and 14 walks.

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