Giants vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 22

Odds updated as of 4:13 a.m.

The MLB's Sunday slate includes the San Francisco Giants facing the Boston Red Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Giants vs Red Sox Game Info

• San Francisco Giants (43-34) vs. Boston Red Sox (40-38)
• Date: Sunday, June 22, 2025
• Time: 4:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and NESN

Giants vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-162) | BOS: (+136)
• Spread: SF: -1.5 (+125) | BOS: +1.5 (-150)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Giants vs Red Sox Probable Starting Pitchers

Probable Pitchers: Robbie Ray (Giants) - 8-2, 2.68 ERA vs Lucas Giolito (Red Sox) - 3-1, 4.73 ERA

The Giants will call on Robbie Ray (8-2) against the Red Sox and Lucas Giolito (3-1). When Ray starts, his team is 10-5-0 against the spread this season. Ray's team has won 72.7% of his starts when they are favored on the moneyline (8-3). The Red Sox have a 6-3-0 record against the spread in Giolito's starts. The Red Sox are 3-1 in Giolito's four starts this season that they were the moneyline underdog.

Giants vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (56%)

Giants vs Red Sox Moneyline

• The moneyline numbers for Giants vs. Red Sox reveal San Francisco as the favorite (-162) and Boston as the underdog (+136) on the road.

Giants vs Red Sox Spread

• The Giants are 1.5-run home favorites on the runline against the Red Sox. The Giants are +125 to cover, and the Red Sox are -150.

Giants vs Red Sox Over/Under

• The over/under for the Giants versus Red Sox game on June 22 has been set at 7.5, with -110 odds on the over and -110 odds on the under.

Bet on San Francisco Giants vs. Boston Red Sox on FanDuel today!

Giants vs Red Sox Betting Trends

• The Giants have been chosen as favorites in 50 games this year and have walked away with the win 29 times (58%) in those games.
• This season San Francisco has come away with a win 10 times in 15 chances when named as a favorite of at least -162 on the moneyline.
• Contests with the Giants have gone over the total set by sportsbooks in 34 of 77 chances this season.
• The Giants have an against the spread record of 34-43-0 in 77 games with a line this season.
• The Red Sox have been the underdog on the moneyline 27 total times this season. They've gone 13-14 in those games.
• Boston is 5-3 (winning 62.5% of its games) when playing as a moneyline underdog of +136 or longer.
• The Red Sox have had an over/under set by oddsmakers 78 times, and have combined with opponents to go over the total in 35 of those games (35-41-2).
• The Red Sox have collected a 42-36-0 record ATS this season (covering 53.8% of the time).

Giants Player Leaders

• Rafael Devers leads San Francisco in OBP (.393) and total hits (78) this season. He's batting .267 batting average while slugging .497.
• Among all qualified hitters in MLB, his batting average ranks 56th, his on-base percentage ranks seventh, and he is 24th in slugging.
• Jung Hoo Lee is batting .255 with 17 doubles, five triples, six home runs and 26 walks. He's slugging .415 with an on-base percentage of .319.
• His batting average ranks 82nd among qualified players, his on-base percentage 101st, and his slugging percentage 95th.
• Heliot Ramos leads San Francisco in slugging percentage (.470) powered by 27 extra-base hits.
• Ramos heads into this game with two games in a row with at least one hit. In his last five games he is hitting .222 with two home runs, two walks and three RBIs.
• Wilmer Flores is batting .255 with a .325 OBP and 54 RBI for San Francisco this season.
• Flores heads into this game on a two-game hitting streak. In his last five games he is batting .154 with a double, a walk and three RBIs.

Red Sox Player Leaders

• Jarren Duran has put up a slugging percentage of .407, a team-best for the Red Sox. He's batting .257 with an on-base percentage of .310.
• He ranks 76th in batting average, 112th in on-base percentage and 101st in slugging percentage among all qualified hitters in MLB.
• Wilyer Abreu's 55 hits and .326 OBP both lead his team. He has a batting average of .255 while slugging .477.
• Including all qualifying hitters, he is 82nd in batting average, 85th in on-base percentage and 36th in slugging percentage.
• Ceddanne Rafaela has 12 doubles, two triples, seven home runs and 14 walks while hitting .251.
• Carlos Narvaez is batting .270 with 15 doubles, six home runs and 26 walks.

Giants vs Red Sox Head to Head

• 6/21/2025: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/20/2025: 7-5 BOS (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/2/2024: 3-1 SF (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/1/2024: 6-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/30/2024: 4-0 BOS (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/30/2023: 4-3 SF (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/29/2023: 3-2 SF (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/28/2023: 3-2 BOS (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)

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