Giants vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 10:12 p.m.

On Wednesday in MLB, the San Francisco Giants are playing the San Diego Padres.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Giants vs Padres Game Info

• San Francisco Giants (14-21) vs. San Diego Padres (20-14)
• Date: Wednesday, May 6, 2026
• Time: 3:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Padres.TV

Giants vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-142) | SD: (+120)
• Spread: SF: -1.5 (+146) | SD: +1.5 (-176)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Giants vs Padres Probable Starting Pitchers

Probable Pitchers: Adrian Houser (Giants) - 0-3, 7.12 ERA vs Matt Waldron (Padres) - 0-1, 9.88 ERA

The Giants will give the ball to Adrian Houser (0-3, 7.12 ERA), who is eyeing win No. 1 on the season, and the Padres will turn to Matt Waldron (0-1, 9.88 ERA). Houser and his team have a record of 1-5-0 against the spread when he starts. Houser's team won his only start as a favorite this season. The Padres have gone 2-1-0 against the spread when Waldron starts. The Padres were named the moneyline underdog for one Waldron start this season -- they lost.

Giants vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (51.7%)

Giants vs Padres Moneyline

• Looking at the moneyline for Giants-Padres, San Francisco is the favorite at -142, and San Diego is +120 playing on the road.

Giants vs Padres Spread

• The Padres are at +1.5 on the runline against the Giants. The Padres are -176 to cover the spread, and the Giants are +146.

Giants vs Padres Over/Under

• Giants versus Padres on May 6 has an over/under of 7.5 runs, with the odds on the over -105 and the under set at -115.

Bet on San Francisco Giants vs. San Diego Padres on FanDuel today!

Giants vs Padres Betting Trends

• The Giants have been favorites in 11 games this season and have come away with the win five times (45.5%) in those contests.
• San Francisco has been listed as a favorite of -142 or more on two occasions this season and split those games.
• The Giants and their opponents have gone over in 14 of their 35 games with a total set by sportsbooks this season.
• The Giants have posted a record of 15-20-0 against the spread this season.
• The Padres are 6-6 in games they were listed as the moneyline underdog (winning 50% of those games).
• San Diego has a record of 2-1 in games it has played as a moneyline underdog with odds of +120 or longer (66.7%).
• The Padres have had an over/under set by oddsmakers 34 times, and have combined with opponents to go over the total in 15 of those games (15-18-1).
• The Padres have a 19-15-0 record ATS this season (covering 55.9% of the time).

Giants Player Leaders

• Luis Arraez leads San Francisco with a slugging percentage of .398, fueled by nine extra-base hits. He has a .316 batting average and an on-base percentage of .340.
• Among qualifying hitters in MLB, his batting average ranks 16th, his on-base percentage ranks 72nd, and he is 94th in slugging.
• Casey Schmitt leads the Giants in OBP (.359) and total hits (33) this season. He's batting .308 while slugging .542.
• Among all qualifying players, he is 21st in batting average, 56th in on-base percentage and 17th in slugging percentage.
• Schmitt enters this matchup looking to extend his six-game hit streak. In his last 10 games he is hitting .361 with a double, a triple, three home runs, three walks and eight RBIs.
• Jung Hoo Lee has collected 34 base hits, an OBP of .321 and a slugging percentage of .400 this season.
• Matt Chapman is batting .246 with a .324 OBP and 12 RBI for San Francisco this season.

Padres Player Leaders

• Xander Bogaerts has a team-high OBP (.343) and slugging percentage (.402). He's batting .262.
• He is 66th in batting average, 70th in on-base percentage and 86th in slugging percentage among all qualified hitters in the big leagues.
• Manny Machado is hitting .221 with four doubles, five home runs and 19 walks. He's slugging .389 with an on-base percentage of .328.
• Including all qualifying hitters, his batting average places him 132nd, his on-base percentage is 90th, and he is 105th in slugging.
• Jackson Merrill is hitting .220 with six doubles, four home runs and 10 walks.
• Ramon Laureano leads his team with 29 hits.

Giants vs Padres Head to Head

• 5/4/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -194, Underdog Moneyline: +150)
• 4/1/2026: 7-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 3/31/2026: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 8/21/2025: 8-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/20/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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