Angels vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 10:11 p.m.

In MLB action on Wednesday, the Los Angeles Angels take on the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Angels vs White Sox Game Info

• Los Angeles Angels (13-23) vs. Chicago White Sox (17-18)
• Date: Wednesday, May 6, 2026
• Time: 4:07 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: ABTV and CHSN

Angels vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAA: (-116) | CHW: (-102)
• Spread: LAA: +1.5 (-192) | CHW: -1.5 (+158)
• Total: 9 -- Over: (-110) | Under: (-110)

Angels vs White Sox Probable Starting Pitchers

Probable Pitchers: Walbert Urena (Angels) - 0-3, 3.86 ERA vs Noah Schultz (White Sox) - 2-1, 2.53 ERA

The probable starters are Walbert Urena (0-3) for the Angels and Noah Schultz (2-1) for the White Sox. Urena and his team are 2-1-0 ATS this season when he starts. This will be Urena's first start this season with his team as the moneyline favorite. The White Sox have a 2-2-0 record against the spread in Schultz's starts. The White Sox are 2-1 in Schultz's three starts this season that they were the moneyline underdog.

Angels vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: White Sox win (51.4%)

Angels vs White Sox Moneyline

• Looking at the moneyline for Angels-White Sox, Los Angeles is the favorite at -116, and Chicago is -102 playing on the road.

Angels vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Angels. The White Sox are +158 to cover, while the Angels are -192 to cover as a 1.5-run underdog on the runline.

Angels vs White Sox Over/Under

• The over/under for Angels-White Sox on May 6 is 9. The over is -110, and the under is -110.

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Angels vs White Sox Betting Trends

• The Angels have been chosen as favorites in six games this year and have walked away with the win two times (33.3%) in those games.
• This season Los Angeles has been victorious two times in five chances when named as a favorite of at least -116 on the moneyline.
• Contests with the Angels have gone over the total set by sportsbooks in 16 of 35 chances this season.
• The Angels have posted a record of 17-18-0 against the spread this season.
• The White Sox are 14-16 in games they were the underdog on the moneyline (winning 46.7% of those games).
• Chicago has a 14-15 record (winning 48.3% of its games) when playing as a moneyline underdog of -102 or longer.
• The White Sox have combined with opponents to go over the total 17 times this season for a 17-16-0 record against the over/under.
• The White Sox have a 19-14-0 record ATS this season.

Angels Player Leaders

• Mike Trout leads Los Angeles in OBP (.422) and total hits (31) this season. He's batting .250 batting average while slugging .532.
• Among qualifying batters in the majors, he is 87th in batting average, fifth in on-base percentage, and 20th in slugging.
• Nolan Schanuel has eight doubles, three home runs and 10 walks. He's batting .256 and slugging .388 with an on-base percentage of .310.
• Among all qualifying players, he is 78th in batting average, 125th in on-base percentage and 106th in slugging percentage.
• Schanuel enters this game looking to extend his four-game hit streak. During his last five outings he is hitting .353 with two doubles.
• Jorge Soler has 27 hits this season and has a slash line of .231/.326/.453.
• Zach Neto has been key for Los Angeles with 30 hits, an OBP of .323 plus a slugging percentage of .371.

White Sox Player Leaders

• Munetaka Murakami has accumulated a team-high OBP (.377), and leads the White Sox in hits (30). He's batting .240 and slugging.
• Including all the qualified hitters in the big leagues, he is 104th in batting average, 34th in on-base percentage and eighth in slugging percentage.
• Miguel Vargas is hitting .228 with four doubles, a triple, seven home runs and 24 walks. He's slugging .447 with an on-base percentage of .360.
• Including all qualifying players, his batting average puts him 126th, his on-base percentage is 52nd, and he is 55th in slugging.
• Colson Montgomery has five doubles, nine home runs and 14 walks while batting .226.
• Chase Meidroth's .344 slugging percentage leads his team.

Angels vs White Sox Head to Head

• 5/4/2026: 6-0 CHW (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/29/2026: 3-2 CHW (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 4/28/2026: 5-2 CHW (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/3/2025: 8-5 LAA (Favorite: Angels, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/2/2025: 1-0 CHW (Favorite: Angels, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 8/1/2025: 6-3 CHW (Favorite: Angels, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/30/2025: 3-2 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 3/29/2025: 1-0 LAA (Favorite: Angels, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 3/27/2025: 8-1 CHW (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/26/2024: 7-0 CHW (Favorite: Angels, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)

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