Cubs vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 11:12 p.m.

MLB action on Friday includes the Chicago Cubs playing the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this matchup.

Cubs vs White Sox Game Info

• Chicago Cubs (25-19) vs. Chicago White Sox (14-30)
• Date: Friday, May 16, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MLB Network, MARQ, and CHSN

Cubs vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-225) | CHW: (+188)
• Spread: CHC: -1.5 (-114) | CHW: +1.5 (-105)
• Total: 11.5 -- Over: (-110) | Under: (-110)

Cubs vs White Sox Probable Starting Pitchers

Probable Pitchers: Cade Horton (Cubs) - 1-0, 6.75 ERA vs Shane Smith (White Sox) - 1-2, 2.08 ERA

The probable pitchers are Cade Horton (1-0) for the Cubs and Shane Smith (1-2) for the White Sox. Horton did not pitch as the moneyline favorite in any games last season. The White Sox have a 3-5-0 record against the spread in Smith's starts. The White Sox have been the moneyline underdog in seven of Smith's starts this season, and they went 1-6 in those matchups.

Cubs vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (61.9%)

Cubs vs White Sox Moneyline

• The Cubs vs White Sox moneyline has the Cubs as a -225 favorite, while the White Sox are a +188 underdog on the road.

Cubs vs White Sox Spread

• The Cubs are 1.5-run favorites on the runline against the White Sox. The Cubs are -114 to cover, while the White Sox are -105 to cover.

Cubs vs White Sox Over/Under

• The over/under for the Cubs versus White Sox contest on May 16 has been set at 11.5, with -110 odds on the over and -110 odds on the under.

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Cubs vs White Sox Betting Trends

• The Cubs have been chosen as favorites in 22 games this year and have walked away with the win 15 times (68.2%) in those games.
• The Cubs have been listed as a favorite of -225 or more on two occasions this season and won both games.
• The Cubs and their opponents have hit the over in 26 of their 42 games with a total this season.
• The Cubs are 21-21-0 against the spread in their 42 games with a line set by sportsbooks this season.
• The White Sox have won 13 of the 42 games they were the moneyline underdog this season (31%).
• When playing as a moneyline underdog with odds of +188 or longer, the White Sox have a record of 2-14 (12.5%).
• The White Sox have played in 43 games with a set over/under, and have combined with their opponents to go over the total 19 times (19-22-2).
• The White Sox are 23-20-0 ATS this season.

Cubs Player Leaders

• Kyle Tucker has an OPS of .898, fueled by an OBP of .371 to go with a slugging percentage of .526. He has a .263 batting average, as well.
• Among all qualified batters in the majors, his batting average ranks 67th, his on-base percentage ranks 34th, and he is 18th in slugging.
• Pete Crow-Armstrong leads Chicago with 45 hits and a team-best slugging percentage of .538. He's batting .266 with an on-base percentage of .306.
• He ranks 63rd in batting average, 113th in on-base percentage and 16th in slugging among qualifying hitters.
• Crow-Armstrong enters this game looking to extend his two-game hit streak. During his last five outings he is batting .263 with two home runs, a walk and three RBIs.
• Seiya Suzuki has 39 hits this season and has a slash line of .239/.298/.509.
• Carson Kelly has eight home runs, 23 RBI and a batting average of .289 this season.

White Sox Player Leaders

• Miguel Vargas has accumulated a team-best .310 on-base percentage. He's batting .221 and slugging .342.
• Including all qualified hitters, he is 130th in batting average, while his on-base percentage ranks 105th and he is 136th in slugging.
• Luis Robert is batting .186 with three doubles, five home runs and 21 walks. He's slugging .314 with an on-base percentage of .290.
• He is 158th in batting average, 131st in on-base percentage and 153rd in slugging percentage in the big leagues.
• Lenyn Sosa has a team-best slugging percentage (.373) and leads the White Sox in hits (40).
• Andrew Vaughn has eight doubles, five home runs and seven walks while batting .189.

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