Cubs vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 2:12 a.m.

The MLB's Saturday slate includes the Chicago Cubs facing the Seattle Mariners.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Mariners Game Info

• Chicago Cubs (45-30) vs. Seattle Mariners (38-36)
• Date: Saturday, June 21, 2025
• Time: 2:20 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and ROOT Sports NW

Cubs vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-162) | SEA: (+136)
• Spread: CHC: -1.5 (+112) | SEA: +1.5 (-134)
• Total: 12 -- Over: (-122) | Under: (-100)

Cubs vs Mariners Probable Starting Pitchers

Probable Pitchers: Cade Horton (Cubs) - 3-1, 3.47 ERA vs Emerson Hancock (Mariners) - 3-2, 4.48 ERA

This contest's pitching matchup is set, as the Cubs will send Cade Horton (3-1) to the mound, while Emerson Hancock (3-2) will answer the bell for the Mariners. Horton and his team are 3-3-0 ATS this season when he starts. Horton's team has a record of 4-1 this season when he starts and they are the favorite on the moneyline. When Hancock starts, the Mariners have gone 8-4-0 against the spread. The Mariners are 5-2 in Hancock's seven starts this season that they were the underdog on the moneyline.

Cubs vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (57.6%)

Cubs vs Mariners Moneyline

• The moneyline numbers for Cubs vs. Mariners reveal Chicago as the favorite (-162) and Seattle as the underdog (+136) on the road.

Cubs vs Mariners Spread

• The Mariners are +1.5 on the run line against the Cubs. The Mariners are -134 to cover, and the Cubs are +112.

Cubs vs Mariners Over/Under

• An over/under of 12 has been set for Cubs-Mariners on June 21, with the over being -122 and the under -100.

Bet on Chicago Cubs vs. Seattle Mariners on FanDuel today!

Cubs vs Mariners Betting Trends

• The Cubs have been chosen as favorites in 48 games this year and have walked away with the win 34 times (70.8%) in those games.
• This year Chicago has won 14 of 20 games when listed as at least -162 on the moneyline.
• The Cubs and their opponents have hit the over in 38 of their 73 games with a total set by oddsmakers this season.
• The Cubs are 37-36-0 against the spread in their 73 games with a line set by sportsbooks this season.
• The Mariners have been the moneyline underdog 25 total times this season. They've finished 13-12 in those games.
• In games it has played as a moneyline underdog with odds of +136 or longer, Seattle has a record of 3-2 (60%).
• In the 73 games bookmakers have set an over/under for the Mariners, they have combined with opponents to go over the total 38 times (38-31-4).
• The Mariners have put together a 32-41-0 record against the spread this season (covering 43.8% of the time).

Cubs Player Leaders

• Kyle Tucker leads Chicago in OBP (.395) this season, fueled by 78 hits. He has a .284 batting average and a slugging percentage of .513.
• Among all qualifying hitters, he ranks 31st in batting average, his on-base percentage ranks eighth, and he is 17th in slugging.
• Pete Crow-Armstrong leads Chicago in total hits (77) this season while batting .266 with 39 extra-base hits. He's slugging .550 with an on-base percentage of .305.
• He is 59th in batting average, 121st in on-base percentage and eighth in slugging among qualified hitters.
• Seiya Suzuki has 73 hits this season and has a slash line of .257/.314/.528.
• Nico Hoerner has an OPS of .685, fueled by an OBP of .329 and a team-best slugging percentage of .356 this season.
• Hoerner brings a six-game hitting streak into this game. During his last 10 outings he is hitting .297 with two doubles, a walk and two RBIs.

Mariners Player Leaders

• Cal Raleigh has racked up 74 hits, a team-best for the Mariners. He's batting .273 and slugging .646 with an on-base percentage of .379.
• Including all qualified hitters in the big leagues, he is 45th in batting average, 17th in on-base percentage and second in slugging percentage.
• Raleigh takes a three-game hitting streak into this matchup. In his last five games he is hitting .400 with two doubles, three home runs, a walk and nine RBIs.
• Julio Rodriguez is slugging .403 to pace his team. He has a batting average of .253 with an on-base percentage of .315.
• He is currently 86th in batting average, 103rd in on-base percentage and 102nd in slugging percentage among all qualified hitters.
• J.P. Crawford a has .409 on-base percentage to lead the Mariners.
• Jorge Polanco is hitting .254 with eight doubles, 11 home runs and 13 walks.

Cubs vs Mariners Head to Head

• 6/20/2025: 9-4 SEA (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/14/2024: 3-2 CHC (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/13/2024: 4-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/12/2024: 4-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/12/2023: 5-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 11, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/11/2023: 14-9 CHC (Favorite: Cubs, Spread: -1.5, Total: 10.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/10/2023: 3-2 CHC (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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