Giants vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 5:12 a.m.

The San Francisco Giants will take on the Boston Red Sox in MLB action on Saturday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Giants vs Red Sox Game Info

• San Francisco Giants (42-34) vs. Boston Red Sox (40-37)
• Date: Saturday, June 21, 2025
• Time: 4:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and NESN

Giants vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-132) | BOS: (+112)
• Spread: SF: -1.5 (+164) | BOS: +1.5 (-200)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Giants vs Red Sox Probable Starting Pitchers

Probable Pitchers: Landen Roupp (Giants) - 4-5, 4.11 ERA vs Brayan Bello (Red Sox) - 3-1, 3.49 ERA

This contest's pitching matchup is set, as the Giants will send Landen Roupp (4-5) to the mound, while Brayan Bello (3-1) will get the nod for the Red Sox. Roupp and his team have a record of 5-9-0 against the spread when he starts. Roupp's team has won 60% of his starts when they are favored on the moneyline (3-2). The Red Sox have gone 7-4-0 against the spread when Bello starts. The Red Sox are 1-3 in Bello's four starts this season that they were the moneyline underdog.

Giants vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (55.5%)

Giants vs Red Sox Moneyline

• Looking at the moneyline for Red Sox-Giants, Boston is the underdog at +112, and San Francisco is -132 playing at home.

Giants vs Red Sox Spread

• The Giants are favored by 1.5 runs at home versus the Red Sox. The Giants are +164 to cover the spread, while the Red Sox are -200.

Giants vs Red Sox Over/Under

• A combined run total of 7.5 has been set for Giants-Red Sox on June 21, with the over at -100 and the under at -122.

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Giants vs Red Sox Betting Trends

• The Giants have been victorious in 28, or 57.1%, of the 49 contests they have been chosen as favorites in this season.
• San Francisco has a record of 22-14 in contests when sportsbooks favor them by -132 or more on the moneyline.
• The Giants and their opponents have gone over the total this season in 34 of their 76 opportunities.
• The Giants have an against the spread mark of 34-42-0 in 76 games with a line this season.
• The Red Sox have gone 13-13 in games they were the underdog on the moneyline (winning 50% of those games).
• Boston has a 7-7 record (winning 50% of its games) when it has played as a moneyline underdog of +112 or longer.
• The Red Sox have played in 77 games with an over/under set, and have combined with opponents to go over the total 35 times (35-40-2).
• The Red Sox have a 41-36-0 record against the spread this season.

Giants Player Leaders

• Rafael Devers leads San Francisco in OBP (.395) and total hits (77) this season. He's batting .267 batting average while slugging .490.
• Among qualifying hitters in the majors, his batting average ranks 56th, his on-base percentage ranks seventh, and he is 24th in slugging.
• Jung Hoo Lee is hitting .255 with 17 doubles, five triples, six home runs and 26 walks. He's slugging .415 with an on-base percentage of .319.
• Among qualifying hitters, his batting average ranks him 80th, his on-base percentage 99th, and his slugging percentage 94th.
• Heliot Ramos leads San Francisco in slugging percentage (.463) powered by 26 extra-base hits.
• Wilmer Flores has been key for San Francisco with 67 hits, an OBP of .325 plus a slugging percentage of .407.
• Flores has hit safely in two straight games. In his last five games he is hitting .154 with a double, a walk and three RBIs.

Red Sox Player Leaders

• Jarren Duran has a team-high .412 slugging percentage. He's batting .260 with an on-base percentage of .313.
• Including all qualified hitters, he ranks 71st in batting average, while his on-base percentage is 109th and he is 96th in slugging.
• Wilyer Abreu paces his team with 53 hits and a .324 OBP. He has a batting average of .250 while slugging .476.
• He is 93rd in batting average, 89th in on-base percentage and 35th in slugging percentage in MLB.
• Ceddanne Rafaela has 12 doubles, two triples, seven home runs and 14 walks while batting .255.
• Carlos Narvaez has 15 doubles, six home runs and 26 walks while batting .270.

Giants vs Red Sox Head to Head

• 6/20/2025: 7-5 BOS (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/2/2024: 3-1 SF (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/1/2024: 6-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/30/2024: 4-0 BOS (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/30/2023: 4-3 SF (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/29/2023: 3-2 SF (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/28/2023: 3-2 BOS (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)

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