Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 8:12 a.m.

The Cleveland Guardians versus the Athletics is on the MLB schedule for Saturday.

We've got you covered, in terms of the vital info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Athletics Game Info

• Cleveland Guardians (37-37) vs. Athletics (32-46)
• Date: Saturday, June 21, 2025
• Time: 10:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and CLEG

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | OAK: (-100)
• Spread: CLE: -1.5 (+130) | OAK: +1.5 (-156)
• Total: 9.5 -- Over: (-110) | Under: (-110)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Logan Allen (Guardians) - 5-4, 4.21 ERA vs Mitch Spence (Athletics) - 2-1, 3.50 ERA

This contest's pitching matchup is set, as the Guardians will send Logan Allen (5-4) to the mound, while Mitch Spence (2-1) will get the nod for the Athletics. Allen's team is 5-7-0 against the spread in his starts this season. Allen and his team have won each of the three games he's started as the moneyline favorite. In each of Spence's three starts that had a set spread, the Athletics covered. The Athletics are 2-1 in Spence's three starts this season that they were the moneyline underdog.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (55.6%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -118 favorite, while the Athletics are a -100 underdog at home.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are +130 to cover, while the Athletics are -156 to cover.

Guardians vs Athletics Over/Under

• The over/under for Guardians-Athletics on June 21 is 9.5. The over is -110, and the under is -110.

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Guardians vs Athletics Betting Trends

• The Guardians have been chosen as favorites in 24 games this year and have walked away with the win 14 times (58.3%) in those games.
• This season, the Guardians have come away with a win 11 times in 19 chances when named as a favorite of at least -118 or shorter on the moneyline.
• The Guardians and their opponents have hit the over in 31 of their 72 games with a total this season.
• The Guardians are 36-36-0 against the spread in their 72 games that had a posted line this season.
• The Athletics have won 21 of the 58 games they were the underdog on the moneyline this season (36.2%).
• The Athletics have gone 19-37 in games they have played as a moneyline underdog with odds of -100 or longer (33.9%).
• The Athletics have played in 78 games with a set over/under, and have combined with their opponents to go over the total 43 times (43-32-3).
• The Athletics have covered 48.7% of their games this season, going 38-40-0 ATS.

Guardians Player Leaders

• Jose Ramirez has 86 hits and an OBP of .378 to go with a slugging percentage of .528. All three of those stats rank first among Cleveland hitters this season. He has a .317 batting average, as well.
• Among qualifying hitters, he is eighth in batting average, his on-base percentage ranks 20th, and he is 12th in slugging.
• Ramirez will look for his fourth straight game with a hit in this matchup. In his last five games he is hitting .158 with a double, a walk and an RBI.
• Steven Kwan has 15 doubles, six home runs and 25 walks. He's batting .299 and slugging .420 with an on-base percentage of .362.
• Among all qualified hitters, he is 16th in batting average, 30th in on-base percentage and 87th in slugging percentage.
• Kwan brings a two-game streak with at least one hit into this matchup. In his last five games he is batting .250 with a double and two walks.
• Carlos Santana has collected 59 base hits, an OBP of .335 and a slugging percentage of .363 this season.
• Kyle Manzardo has 11 home runs, 31 RBI and a batting average of .212 this season.

Athletics Player Leaders

• Jacob Wilson has racked up a team-best OBP (.397) and slugging percentage (.505), and leads the Athletics in hits (102, while batting .358).
• Including all qualifying players, he ranks second in batting average, while his on-base percentage is sixth and he is 20th in slugging.
• Wilson hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .222 with a home run, two walks and two RBIs.
• Brent Rooker is batting .271 with 16 doubles, a triple, 15 home runs and 34 walks. He's slugging .477 with an on-base percentage of .348.
• He is currently 49th in batting average, 54th in on-base percentage and 34th in slugging percentage among all qualifying hitters.
• Tyler Soderstrom is hitting .249 with 11 doubles, a triple, 14 home runs and 33 walks.
• Lawrence Butler is batting .264 with 23 doubles, a triple, 11 home runs and 27 walks.

Guardians vs Athletics Head to Head

• 6/20/2025: 5-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/21/2024: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/20/2024: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/19/2024: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 3/31/2024: 4-3 OAK (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 3/30/2024: 12-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/29/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 3/28/2024: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/22/2023: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/21/2023: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -188, Underdog Moneyline: +158)

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