Cardinals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 1:11 p.m.

MLB action on Sunday includes the St. Louis Cardinals facing the Cleveland Guardians.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Guardians Game Info

• St. Louis Cardinals (78-77) vs. Cleveland Guardians (90-66)
• Date: Sunday, September 22, 2024
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: BSGL

Cardinals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-124) | CLE: (+106)
• Spread: STL: -1.5 (+164) | CLE: +1.5 (-200)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Cardinals vs Guardians Probable Starting Pitchers

Probable Pitchers: Andre Pallante (Cardinals) - 7-8, 3.87 ERA vs Gavin Williams (Guardians) - 3-10, 5.12 ERA

The Cardinals will call on Andre Pallante (7-8) against the Guardians and Gavin Williams (3-10). Pallante's team is 8-10-0 against the spread in his starts this season. Pallante's team has won 50% of his starts when they are favored on the moneyline (2-2). The Guardians are 3-11-0 against the spread when Williams starts. The Guardians have a 1-3 record in Williams' four starts this season when they were the underdog on the moneyline.

Cardinals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (54.5%)

Cardinals vs Guardians Moneyline

• St. Louis is the favorite, -124 on the moneyline, while Cleveland is a +106 underdog on the road.

Cardinals vs Guardians Spread

• The Guardians are at the Cardinals, and are +1.5 on the runline. The Guardians are +164 to cover the spread, and the Cardinals are -200.

Cardinals vs Guardians Over/Under

• An over/under of 7.5 has been set for Cardinals-Guardians on Sept. 22, with the over being -110 and the under -110.

Bet on St. Louis Cardinals vs. Cleveland Guardians on FanDuel today!

Cardinals vs Guardians Betting Trends

• The Cardinals have come away with 33 wins in the 68 contests they have been listed as the favorites in this season.
• This year St. Louis has won 23 of 49 games when listed as at least -124 on the moneyline.
• The Cardinals and their opponents have hit the over in 69 of their 150 games with a total set by oddsmakers this season.
• In 150 games with a line this season, the Cardinals have a mark of 72-78-0 against the spread.
• The Guardians have compiled a 26-31 record in games they were listed as the moneyline underdog (winning 45.6% of those games).
• Cleveland has a 13-22 record (winning only 37.1% of its games) when playing as a moneyline underdog of +106 or longer.
• The Guardians have had an over/under set by bookmakers 154 times, and have combined with opponents to go over the total in 70 of those games (70-76-8).
• The Guardians have put together an 82-72-0 record ATS this season.

Cardinals Player Leaders

• Brendan Donovan leads St. Louis with an OBP of .339, plus a team-best slugging percentage of .409. He's batting .273 on the season.
• Among qualified hitters in the majors, his batting average ranks 32nd, his on-base percentage ranks 40th, and he is 80th in slugging.
• Alec Burleson leads St. Louis with 141 hits. He is batting .269 this season and has 41 extra-base hits. He's also slugging .427 with an on-base percentage of .312.
• He is 39th in batting average, 96th in on-base percentage and 66th in slugging in the major leagues.
• Nolan Arenado is batting .268 with a .393 slugging percentage and 69 RBI this year.
• Arenado heads into this matchup with two games in a row with at least one hit. In his last five games he is hitting .313 with a double, three walks and two RBI.
• Masyn Winn has been key for St. Louis with 149 hits, an OBP of .313 plus a slugging percentage of .406.

Guardians Player Leaders

• Jose Ramirez has a team-best slugging percentage (.523) and leads the Guardians in hits (166). He's batting .276 and with an on-base percentage of .333.
• Including all the qualified hitters in the majors, his batting average places him 29th, his on-base percentage is 49th, and he is 12th in slugging.
• Josh Naylor is hitting .241 with 26 doubles, 31 home runs and 56 walks. He's slugging .459 with an on-base percentage of .318.
• Including all qualified players, he is 98th in batting average, 86th in on-base percentage and 41st in slugging percentage.
• Andres Gimenez is hitting .257 with 22 doubles, a triple, nine home runs and 26 walks.
• Lane Thomas is batting .241 with 26 doubles, three triples, 14 home runs and 44 walks.

Cardinals vs Guardians Head to Head

• 9/21/2024: 6-5 STL (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/20/2024: 5-1 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2023: 4-3 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2023: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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