Padres vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 12:16 p.m.

The MLB schedule on Sunday includes the San Diego Padres taking on the Chicago White Sox.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs White Sox Game Info

• San Diego Padres (89-66) vs. Chicago White Sox (36-119)
• Date: Sunday, September 22, 2024
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA

Padres vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-290) | CHW: (+235)
• Spread: SD: -1.5 (-140) | CHW: +1.5 (+116)
• Total: 8 -- Over: (-118) | Under: (-104)

Padres vs White Sox Probable Starting Pitchers

Probable Pitchers: Yu Darvish (Padres) - 6-3, 3.21 ERA vs Sean Burke (White Sox) - 1-0, 2.25 ERA

The Padres will give the ball to Yu Darvish (6-3, 3.21 ERA), who is eyeing win No. 7 on the season, and the White Sox will counter with Sean Burke (1-0, 2.25 ERA). Darvish and his team have a record of 7-6-0 against the spread when he starts. Darvish's team has won 71.4% of his starts when they are favored on the moneyline (5-2). Burke has started only one game with a set spread, which the White Sox covered. The White Sox were the underdog on the moneyline for one Burke start this season -- they won.

Padres vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (70.8%)

Padres vs White Sox Moneyline

• Chicago is the underdog, +235 on the moneyline, while San Diego is a -290 favorite at home.

Padres vs White Sox Spread

• The Padres are hosting the White Sox and are favored by 1.5 runs (-140 to cover) on the runline. Chicago is +116 to cover.

Padres vs White Sox Over/Under

• Padres versus White Sox, on Sept. 22, has an over/under of 8, with the over being -118 and the under -104.

Bet on San Diego Padres vs. Chicago White Sox on FanDuel today!

Padres vs White Sox Betting Trends

• The Padres have won in 56, or 57.7%, of the 97 contests they have been named as odds-on favorites in this year.
• San Diego has a record of 2-1 in contests when bookmakers favor them by -290 or more on the moneyline.
• The Padres and their opponents have gone over the total this season in 80 of their 153 opportunities.
• In 153 games with a line this season, the Padres have a mark of 77-76-0 against the spread.
• The White Sox have won 29 of the 142 games they were the moneyline underdog this season (20.4%).
• When it has played as a moneyline underdog with odds of +235 or longer, Chicago has a 3-14 record (winning only 17.6% of its games).
• The White Sox have played in 150 games with an over/under set, and have combined with opponents to go over the total 66 times (66-78-6).
• The White Sox have collected a 60-90-0 record ATS this season (covering 40% of the time).

Padres Player Leaders

• Jurickson Profar leads San Diego with an OBP of .385 this season while batting .283 with 75 walks and 89 runs scored. He has a slugging percentage of .462.
• Among all qualifying hitters in MLB, he ranks 21st in batting average, sixth in on-base percentage, and 39th in slugging.
• Profar will look for his third straight game with a hit in this contest. During his last five outings he is batting .389 with two doubles, a home run, a walk and an RBI.
• Manny Machado is hitting .277 with 29 doubles, 29 home runs and 42 walks. He's slugging .481 with an on-base percentage of .326.
• Among qualifying batters, he is 28th in batting average, 63rd in on-base percentage and 23rd in slugging percentage.
• Jackson Merrill leads San Diego with 157 hits. He is batting .294 this season and 59 of his hits have gone for extra bases.
• Merrill enters this matchup with three games in a row with at least one hit. During his last five outings he is batting .471 with two doubles, a home run, three walks and four RBI.
• Luis Arraez has an OPS of .738, fueled by an OBP of .350 and a team-best slugging percentage of .388 this season.

White Sox Player Leaders

• Andrew Vaughn has accumulated a slugging percentage of .410 and has 133 hits, both team-best numbers for the White Sox. He's batting .246 and with an on-base percentage of .299.
• Including all the qualified hitters in the majors, his batting average puts him 85th, his on-base percentage is 112th, and he is 78th in slugging.
• Andrew Benintendi is hitting .226 with 19 doubles, 19 home runs and 41 walks. He's slugging .393 with an on-base percentage of .289.
• He is currently 119th in batting average, 122nd in on-base percentage and 98th in slugging percentage among all qualified batters.
• Gavin Sheets has put up an on-base percentage of .308, a team-best for the White Sox.
• Nicky Lopez is batting .243 with 12 doubles, three triples, a home run and 37 walks.

Padres vs White Sox Head to Head

• 9/21/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 9/20/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 10/1/2023: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/30/2023: 6-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/29/2023: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 10/2/2022: 2-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2022: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/30/2022: 3-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)

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