Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 11:11 p.m.

The Milwaukee Brewers are among the MLB teams in action on Wednesday, up against the St. Louis Cardinals.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (18-16) vs. St. Louis Cardinals (21-14)
• Date: Wednesday, May 6, 2026
• Time: 1:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Brewers.TV

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-110) | STL: (-106)
• Spread: MIL: -1.5 (+152) | STL: +1.5 (-184)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 2-2, 2.84 ERA vs Matthew Liberatore (Cardinals) - 1-1, 4.50 ERA

The Brewers will give the nod to Jacob Misiorowski (2-2) versus the Cardinals and Matthew Liberatore (1-1). When Misiorowski starts, his team is 4-3-0 against the spread this season. Misiorowski's team has a record of 3-2 this season when he starts and they are the favorite on the moneyline. The Cardinals have gone 4-3-0 ATS in Liberatore's seven starts with a set spread. The Cardinals have been the underdog on the moneyline in seven of Liberatore's starts this season, and they went 5-2 in those matchups.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (56.9%)

Brewers vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Brewers, St. Louis is the underdog at -106, and Milwaukee is -110 playing on the road.

Brewers vs Cardinals Spread

• The Brewers are 1.5-run road favorites on the runline against the Cardinals. The Brewers are +152 to cover, and the Cardinals are -184.

Brewers vs Cardinals Over/Under

• The over/under for the Brewers versus Cardinals game on May 6 has been set at 8.5, with +100 odds on the over and -122 odds on the under.

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Brewers vs Cardinals Betting Trends

• The Brewers have been victorious in 13, or 59.1%, of the 22 contests they have been chosen as favorites in this season.
• Milwaukee has a record of 13-9 in contests when bookmakers favor them by -110 or more on the moneyline.
• The Brewers and their opponents have gone over in 17 of their 34 games with a total set by sportsbooks this season.
• The Brewers have an against the spread record of 20-14-0 in 34 games with a line this season.
• The Cardinals have won 19 of the 32 games they were listed as the moneyline underdog this season (59.4%).
• When it has played as a moneyline underdog with odds of -106 or longer, St. Louis has a 19-13 record (winning 59.4% of its games).
• The Cardinals have played in 35 games with a set over/under, and have combined with opponents to go over the total 18 times (18-15-2).
• The Cardinals have a 22-13-0 record against the spread this season.

Brewers Player Leaders

• Brice Turang leads Milwaukee with 35 hits and an OBP of .434 this season. He has a .304 batting average and a slugging percentage of .522.
• He ranks 26th in batting average, third in on-base percentage, and 22nd in slugging among all qualified hitters in baseball.
• Turang has recorded a base hit in six games in a row. During his last 10 games he is hitting .324 with three doubles, a home run, eight walks and four RBIs.
• William Contreras has an OPS of .767, fueled by an OBP of .357 and a team-best slugging percentage of .411 this season. He's batting .287.
• His batting average is 37th among qualified players, his on-base percentage 58th, and his slugging percentage 80th.
• Jake Bauers has collected 28 base hits, an OBP of .325 and a slugging percentage of .434 this season.
• Bauers takes a two-game hitting streak into this matchup. During his last five outings he is hitting .176 with a double, five walks and an RBI.
• Sal Frelick has three home runs, nine RBI and a batting average of .212 this season.

Cardinals Player Leaders

• Jordan Walker has a team-best slugging percentage (.585) and leads the Cardinals in hits (40). He's batting .308 and with an on-base percentage of .377.
• Including all qualifying hitters in MLB, he ranks 21st in batting average, 34th in on-base percentage and seventh in slugging percentage.
• Alec Burleson is hitting .269 with nine doubles, five home runs and 17 walks. He's slugging .448 with an on-base percentage of .349.
• He ranks 58th in batting average, 67th in on-base percentage and 53rd in slugging percentage in MLB.
• JJ Wetherholt has five doubles, seven home runs and 18 walks while batting .246.
• Ivan Herrera's .416 OBP paces his team.

Brewers vs Cardinals Head to Head

• 5/4/2026: 6-3 STL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/21/2025: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/20/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/19/2025: 7-1 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/13/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

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