Blue Jays vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 25

Odds updated as of 9:11 a.m.

The MLB's Thursday schedule includes the Toronto Blue Jays taking on the Boston Red Sox.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Blue Jays vs Red Sox Game Info

• Toronto Blue Jays (90-68) vs. Boston Red Sox (87-71)
• Date: Thursday, September 25, 2025
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SNET and NESN

Blue Jays vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-132) | BOS: (+112)
• Spread: TOR: -1.5 (+164) | BOS: +1.5 (-200)
• Total: 8 -- Over: (-115) | Under: (-105)

Blue Jays vs Red Sox Probable Starting Pitchers

Probable Pitchers: Louie Varland (Blue Jays) - 4-3, 3.10 ERA vs Brayan Bello (Red Sox) - 11-8, 3.34 ERA

This contest's pitching matchup is set, as the Blue Jays will send Louie Varland (4-3) to the mound, while Brayan Bello (11-8) will get the nod for the Red Sox. Varland and his team were 1-6-0 ATS in games he pitched last year. Varland and his team lost both of the two games he appeared in last season when they were the moneyline favorite. The Red Sox have gone 16-11-0 ATS in Bello's 27 starts with a set spread. The Red Sox have a 3-7 record in Bello's 10 starts this season when they were the moneyline underdog.

Blue Jays vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (58.9%)

Blue Jays vs Red Sox Moneyline

• The moneyline numbers for Blue Jays vs. Red Sox reveal Toronto as the favorite (-132) and Boston as the underdog (+112) on the road.

Blue Jays vs Red Sox Spread

• The Red Sox are +1.5 on the run line against the Blue Jays. The Red Sox are -200 to cover, and the Blue Jays are +164.

Blue Jays vs Red Sox Over/Under

• A total of 8 runs has been set for the Blue Jays-Red Sox game on Sept. 25, with the over available at -115 and the under at -105.

Bet on Toronto Blue Jays vs. Boston Red Sox on FanDuel today!

Blue Jays vs Red Sox Betting Trends

• The Blue Jays have been victorious in 45, or 57%, of the 79 contests they have been chosen as favorites in this season.
• Toronto has a record of 36-19 when favored by -132 or more this year.
• The Blue Jays' games have gone over the total in 85 of their 157 opportunities.
• The Blue Jays have an against the spread record of 88-69-0 in 157 games with a line this season.
• The Red Sox have compiled a 24-27 record in games they were listed as the moneyline underdog (winning 47.1% of those games).
• In games it has played as a moneyline underdog with odds of +112 or longer, Boston has gone 12-17 (41.4%).
• The Red Sox have had an over/under set by oddsmakers 157 times, and have combined with opponents to go over the total in 74 of those games (74-76-7).
• The Red Sox are 84-73-0 ATS this season.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has 34 doubles, 23 home runs and 81 walks while batting .295. He has an on-base percentage of .386 and a slugging percentage of .476.
• Among all qualifying batters in baseball, his batting average ranks ninth, his on-base percentage ranks sixth, and he is 35th in slugging.
• George Springer leads Toronto with 146 hits and an OBP of .390 this season. He's batting .302 and slugging .543.
• He ranks sixth in batting average, fourth in on-base percentage and sixth in slugging in the majors.
• Ernie Clement is batting .276 with a .398 slugging percentage and 47 RBI this year.
• Alejandro Kirk has 12 home runs, 69 RBI and a batting average of .280 this season.

Red Sox Player Leaders

• Jarren Duran has put up a team-high OBP (.333), while pacing the Red Sox in hits (156). He's batting .257 and slugging.
• He is 76th in batting average, 66th in on-base percentage and 61st in slugging percentage among all qualifying batters in the majors.
• Trevor Story leads his team with a .440 slugging percentage. He has a batting average of .267 with an on-base percentage of .312.
• His batting average ranks 43rd among all qualified players, his on-base percentage ranks 107th, and he is 65th in slugging.
• Alex Bregman is batting .275 with 27 doubles, 18 home runs and 50 walks.
• Ceddanne Rafaela is hitting .246 with 32 doubles, three triples, 16 home runs and 27 walks.

Blue Jays vs Red Sox Head to Head

• 9/24/2025: 7-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/23/2025: 4-1 BOS (Favorite: Blue Jays, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/29/2025: 5-3 TOR (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/28/2025: 15-1 BOS (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/27/2025: 9-0 TOR (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/1/2025: 4-2 TOR (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2025: 7-6 TOR (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/29/2025: 10-2 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/10/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/9/2025: 2-1 TOR (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

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