Blue Jays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 2

Odds updated as of 2:12 a.m.

In MLB action on Wednesday, the Toronto Blue Jays play the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Blue Jays vs Guardians Game Info

• Toronto Blue Jays (68-71) vs. Cleveland Guardians (70-68)
• Date: Wednesday, September 2, 2026
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and SNET

Blue Jays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-134) | CLE: (+114)
• Spread: TOR: -1.5 (+134) | CLE: +1.5 (-162)
• Total: 7 -- Over: (-115) | Under: (-105)

Blue Jays vs Guardians Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Blue Jays) - 9-5, 2.33 ERA vs Joey Cantillo (Guardians) - 9-7, 3.70 ERA

The Blue Jays will give the ball to Dylan Cease (9-5, 2.33 ERA), who is eyeing win No. 10 on the season, and the Guardians will counter with Joey Cantillo (9-7, 3.70 ERA). When Cease starts, his team is 15-10-0 against the spread this season. Cease's team has won 61.9% of his starts when they are favored on the moneyline (13-8). The Guardians are 17-11-0 ATS in Cantillo's 28 starts with a set spread. The Guardians are 9-4 in Cantillo's 13 starts this season that they were the underdog on the moneyline.

Blue Jays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (50.2%)

Blue Jays vs Guardians Moneyline

• Looking at the moneyline for Guardians-Blue Jays, Cleveland is the underdog at +114, and Toronto is -134 playing on the road.

Blue Jays vs Guardians Spread

• The Guardians are +1.5 on the run line against the Blue Jays. The Guardians are -162 to cover, and the Blue Jays are +134.

Blue Jays vs Guardians Over/Under

• An over/under of 7 has been set for Blue Jays-Guardians on Sept. 2, with the over being -115 and the under -105.

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Blue Jays vs Guardians Betting Trends

• The Blue Jays have been chosen as favorites in 66 games this year and have walked away with the win 36 times (54.5%) in those games.
• Toronto has a record of 19-16 in contests when oddsmakers favor them by -134 or more on the moneyline.
• The Blue Jays and their opponents have hit the over in 68 of their 135 games with a total set by oddsmakers this season.
• The Blue Jays are 66-69-0 against the spread in their 135 games with a line set by sportsbooks this season.
• The Guardians have won 51% of the games this season they were the moneyline underdog (26-25).
• Cleveland has a record of 16-11 when it has played as a moneyline underdog with odds of +114 or longer (59.3%).
• In the 132 games bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 63 times (63-69-0).
• The Guardians have a 64-68-0 record against the spread this season.

Blue Jays Player Leaders

• Ernie Clement has an OPS of .690, fueled by an OBP of .301 and a team-best slugging percentage of .389 this season. He has a .275 batting average.
• Among qualified hitters, he ranks 33rd in batting average, his on-base percentage ranks 118th, and he is 103rd in slugging.
• Vladimir Guerrero Jr. leads Toronto with an OBP of .330 this season while batting .258 with 49 walks and 63 runs scored. He's slugging .348.
• Among qualifying hitters, he is 62nd in batting average, 73rd in on-base percentage and 133rd in slugging percentage.
• Guerrero enters this game looking to extend his two-game hit streak. During his last five outings he is batting .158 with a double, two walks and two RBIs.
• Kazuma Okamoto has 112 hits and is batting .229 this season.
• Okamoto has picked up a hit in two straight games. In his last five games he is hitting .267 with a double, two home runs, three walks and four RBIs.
• George Springer has been key for Toronto with 99 hits, an OBP of .327 plus a slugging percentage of .416.

Guardians Player Leaders

• Chase DeLauter has racked up a slugging percentage of .450 and has 125 hits, both team-high numbers for the Guardians. He's batting .290 and with an on-base percentage of .362.
• He ranks 10th in batting average, 27th in on-base percentage and 44th in slugging percentage among all qualified batters in the big leagues.
• Jose Ramirez is batting .244 with 24 doubles, 11 home runs and 56 walks. He's slugging .391 with an on-base percentage of .338.
• He is currently 92nd in batting average, 58th in on-base percentage and 100th in slugging percentage among all qualified batters.
• Steven Kwan has racked up an on-base percentage of .376, a team-best for the Guardians.
• Brayan Rocchio has 19 doubles, two triples, 10 home runs and 32 walks while batting .246.

Blue Jays vs Guardians Head to Head

• 9/1/2026: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/26/2026: 4-2 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/25/2026: 5-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/24/2026: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/26/2025: 6-0 TOR (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/25/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/24/2025: 10-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/4/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/3/2025: 5-3 CLE (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/2/2025: 5-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)

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