Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 2

Odds updated as of 7:12 p.m.

On Wednesday in MLB, the Houston Astros are up against the Chicago White Sox.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs White Sox Game Info

• Houston Astros (70-69) vs. Chicago White Sox (73-65)
• Date: Wednesday, September 2, 2026
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and CHSN

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-164) | CHW: (+138)
• Spread: HOU: -1.5 (+134) | CHW: +1.5 (-162)
• Total: 8 -- Over: (-122) | Under: (+100)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: Hayden Wesneski (Astros) - 4-1, 3.86 ERA vs Davis Martin (White Sox) - 9-6, 4.32 ERA

This contest's pitching matchup is set, as the Astros will send Hayden Wesneski (4-1) to the mound, while Davis Martin (9-6) will get the nod for the White Sox. Wesneski's team is 5-1-0 against the spread this season in his starts. Wesneski's team has a record of 4-1 this season when he starts and they are the favorite on the moneyline. The White Sox have a 13-11-0 record against the spread in Martin's starts. The White Sox have been the underdog on the moneyline in 15 of Martin's starts this season, and they went 10-5 in those matchups.

Astros vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (51.4%)

Astros vs White Sox Moneyline

• Looking at the moneyline for White Sox-Astros, Chicago is the underdog at +138, and Houston is -164 playing at home.

Astros vs White Sox Spread

• The Astros are hosting the White Sox and are favored by 1.5 runs (+134 to cover) on the runline. Chicago is -162 to cover.

Astros vs White Sox Over/Under

• The over/under for Astros-White Sox on Sept. 2 is 8. The over is -122, and the under is +100.

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Astros vs White Sox Betting Trends

• The Astros have been chosen as favorites in 59 games this year and have walked away with the win 30 times (50.8%) in those games.
• Houston has a record of 5-9 when favored by -164 or more this year.
• The Astros and their opponents have gone over the total this season in 72 of their 139 opportunities.
• The Astros have an against the spread mark of 67-72-0 in 139 games with a line this season.
• The White Sox have won 49 of the 99 games they were the underdog on the moneyline this season (49.5%).
• Chicago is 7-14 (winning just 33.3% of its games) when it has played as a moneyline underdog of +138 or longer.
• The White Sox have played in 135 games with a set over/under, and have combined with their opponents to go over the total 75 times (75-59-1).
• The White Sox have put together a 79-56-0 record against the spread this season (covering 58.5% of the time).

Astros Player Leaders

• Yordan Alvarez has 155 hits and an OBP of .433 to go with a slugging percentage of .603. All three of those stats are best among Houston hitters this season. He has a .316 batting average, as well.
• Among qualified hitters in baseball, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes is hitting .256 with 23 doubles, a triple, 18 home runs and 59 walks, while slugging .421 with an on-base percentage of .355.
• He is 64th in batting average, 35th in on-base percentage and 67th in slugging in the majors.
• Paredes brings a two-game streak with at least one hit into this one. During his last five outings he is hitting .118 with a home run, four walks and an RBI.
• Christian Walker is batting .227 with a .427 slugging percentage and 76 RBI this year.
• Jeremy Pena has 17 home runs, 46 RBI and a batting average of .281 this season.

White Sox Player Leaders

• Miguel Vargas is hitting .251 with 30 doubles, a triple, 29 home runs and 86 walks. He's slugging .488 with an on-base percentage of .365.
• He is 79th in batting average, 24th in on-base percentage and 23rd in slugging percentage among all qualifying batters in MLB.
• Vargas heads into this matchup on a three-game hitting streak. In his last five games he is hitting .263 with four walks.
• Chase Meidroth is slugging .401 to pace his team. He has a batting average of .273 with an on-base percentage of .347.
• His batting average ranks 39th among all qualified players, his on-base percentage is 45th, and he is 93rd in slugging.
• Sam Antonacci has put up an on-base percentage of .366, a team-high for the White Sox.
• Tristan Peters is batting .276 with 27 doubles, three triples, 12 home runs and 33 walks.

Astros vs White Sox Head to Head

• 9/1/2026: 5-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2026: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +118)
• 7/26/2026: 12-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/25/2026: 4-1 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/10/2025: 4-2 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/4/2025: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/3/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)

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