Astros vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for April 22

Odds updated as of 4:16 a.m.

In MLB action on Tuesday, the Houston Astros play the Toronto Blue Jays.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

Astros vs Blue Jays Game Info

• Houston Astros (11-11) vs. Toronto Blue Jays (12-11)
• Date: Tuesday, April 22, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and SN1

Astros vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-112) | TOR: (-104)
• Spread: HOU: +1.5 (-178) | TOR: -1.5 (+146)
• Total: 8 -- Over: (-110) | Under: (-110)

Astros vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Ronel Blanco (Astros) - 1-2, 6.48 ERA vs Christopher Michael Bassitt (Blue Jays) - 2-0, 0.77 ERA

The probable starters are Ronel Blanco (1-2) for the Astros and Christopher Michael Bassitt (2-0) for the Blue Jays. Blanco and his team have a record of 2-2-0 against the spread when he starts. Blanco's team is 1-1 this season when he starts and they're favored on the moneyline. The Blue Jays covered in each of the four games Bassitt started that had a spread set by oddsmakers. The Blue Jays have a 1-2 record in Bassitt's three starts this season when they were the underdog on the moneyline.

Astros vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (56.4%)

Astros vs Blue Jays Moneyline

• The moneyline numbers for Astros vs. Blue Jays reveal Houston as the favorite (-112) and Toronto as the underdog (-104) on the road.

Astros vs Blue Jays Spread

• The Blue Jays are 1.5-run favorites against the spread for this matchup with the Astros. The Blue Jays are +146 to cover, while the Astros are -178 to cover as a 1.5-run underdog on the runline.

Astros vs Blue Jays Over/Under

• A total of 8 runs has been set for the Astros-Blue Jays contest on April 22, with the over available at -110 and the under at -110.

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Astros vs Blue Jays Betting Trends

• The Astros have come away with seven wins in the 14 contests they have been listed as the favorites in this season.
• This season Houston has come away with a win seven times in 14 chances when named as a favorite of at least -112 on the moneyline.
• The Astros' games have gone over the total in eight of their 22 opportunities.
• The Astros are 12-10-0 against the spread in their 22 games that had a posted line this season.
• The Blue Jays have gone 7-9 in games they were listed as the moneyline underdog (winning 43.8% of those games).
• Toronto has a 5-9 record (winning only 35.7% of its games) when playing as a moneyline underdog of -104 or longer.
• In the 23 games oddsmakers have set an over/under for the Blue Jays, they have combined with opponents to go over the total nine times (9-13-1).
• The Blue Jays are 16-7-0 against the spread this season.

Astros Player Leaders

• Jeremy Pena is hitting .228 with three doubles, three home runs and eight walks. He has an on-base percentage of .311 and a slugging percentage of .380.
• Among qualifying hitters in the majors, he is 105th in batting average, 99th in on-base percentage, and 99th in slugging.
• Pena hopes to build on a 12-game hitting streak in this matchup. During his last 10 outings he is batting .278 with two doubles, a home run, four walks and five RBI.
• Jose Carlos Altuve leads Houston with 27 hits and a team-best slugging percentage of .427. He's batting .303 with an on-base percentage of .337.
• He is 31st in batting average, 75th in on-base percentage and 73rd in slugging among qualifying hitters.
• Altuve brings a two-game streak with at least one hit into this contest. In his last five games he is hitting .316 with a double, a walk and two RBI.
• Isaac Paredes leads Houston in OBP (.344) this season, fueled by 19 hits.
• Yordan Ruben Alvarez has been key for Houston with 15 hits, an OBP of .318 plus a slugging percentage of .338.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. is batting .291 with six doubles, a home run and 14 walks. He's slugging .395 with an on-base percentage of .392.
• Including all the qualifying hitters in the majors, his batting average ranks 39th, his on-base percentage is 23rd, and he is 89th in slugging.
• Bo Joseph Bichette's .390 slugging percentage leads his team. He has a batting average of .310 with an on-base percentage of .352.
• He ranks 23rd in batting average, 57th in on-base percentage and 92nd in slugging percentage in the majors.
• Andres Gimenez is batting .198 with four doubles, three home runs and eight walks.
• George Springer's 22 hits and .425 OBP are both team-highs.

Astros vs Blue Jays Head to Head

• 4/21/2025: 7-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2024: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/3/2024: 9-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/2/2024: 7-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/1/2024: 3-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/3/2024: 8-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 4/2/2024: 2-1 TOR (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 4/1/2024: 10-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 6/8/2023: 3-2 TOR (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/7/2023: 3-2 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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