Yankees vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 9:12 p.m.

The MLB's Wednesday schedule includes the New York Yankees taking on the Minnesota Twins.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Twins Game Info

• New York Yankees (87-63) vs. Minnesota Twins (70-80)
• Date: Wednesday, September 16, 2026
• Time: 1:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: Twins.TV and YES

Yankees vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-148) | MIN: (+126)
• Spread: NYY: -1.5 (+114) | MIN: +1.5 (-137)
• Total: 7.5 -- Over: (-132) | Under: (+108)

Yankees vs Twins Probable Starting Pitchers

Probable Pitchers: Carlos Rodon (Yankees) - 6-3, 2.94 ERA vs Zebby Matthews (Twins) - 9-10, 4.98 ERA

The Yankees will give the nod to Carlos Rodon (6-3, 2.94 ERA), who is eyeing win No. 7 on the season, and the Twins will turn to Zebby Matthews (9-10, 4.98 ERA). Rodon's team is 7-7-0 against the spread in his starts this season. Rodon's team is 7-3 this season when he starts and they are the moneyline favorite. The Twins have gone 12-8-0 against the spread when Matthews starts. The Twins have been the moneyline underdog in 11 of Matthews' starts this season, and they went 6-5 in those matchups.

Yankees vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (57.2%)

Yankees vs Twins Moneyline

• Looking at the moneyline for Yankees-Twins, New York is the favorite at -148, and Minnesota is +126 playing at home.

Yankees vs Twins Spread

• The Yankees are at the Twins and are favored by 1.5 runs on the spread. The Yankees are +114 to cover the runline, with the Twins being -137.

Yankees vs Twins Over/Under

• The over/under for the Yankees versus Twins contest on Sept. 16 has been set at 7.5, with -132 odds on the over and +108 odds on the under.

Bet on New York Yankees vs. Minnesota Twins on FanDuel today!

Yankees vs Twins Betting Trends

• The Yankees have won in 70, or 60.3%, of the 116 contests they have been named as odds-on favorites in this year.
• This year New York has won 36 of 56 games when listed as at least -148 on the moneyline.
• The Yankees and their opponents have gone over in 65 of their 145 games with a total set by sportsbooks this season.
• In 145 games with a line this season, the Yankees have a mark of 75-70-0 against the spread.
• The Twins have been the moneyline underdog 88 total times this season. They've gone 38-50 in those games.
• When it has played as a moneyline underdog with odds of +126 or longer, Minnesota has a record of 12-17 (41.4%).
• The Twins have had an over/under set by oddsmakers 146 times, and have combined with opponents to go over the total in 82 of those games (82-61-3).
• The Twins have collected a 78-68-0 record ATS this season.

Yankees Player Leaders

• Ben Rice leads New York with an OBP of .359, plus a team-best slugging percentage of .529. He's batting .263 on the season.
• Among qualified batters, he ranks 59th in batting average, his on-base percentage ranks 32nd, and he is fifth in slugging.
• Rice hopes to build on a four-game hitting streak in this matchup. In his last five games he is hitting .389 with two home runs, three walks and four RBIs.
• Luis Garcia leads New York in total hits (139) this season while batting .287 with 61 extra-base hits. He's slugging .546 with an on-base percentage of .318.
• Among qualifying hitters, he is 15th in batting average, 93rd in on-base percentage and third in slugging percentage.
• Cody Bellinger is batting .268 with a .434 slugging percentage and 69 RBI this year.
• Jose Caballero is batting .235 with a .292 OBP and 49 RBI for New York this season.

Twins Player Leaders

• Brooks Lee is hitting .247 with 23 doubles, three triples, 23 home runs and 35 walks. He's slugging .429 with an on-base percentage of .297.
• Including all the qualified hitters in the majors, he ranks 86th in batting average, 121st in on-base percentage and 65th in slugging percentage.
• Josh Bell's .427 slugging percentage paces his team. He has a batting average of .255 with an on-base percentage of .320.
• He ranks 70th in batting average, 85th in on-base percentage and 68th in slugging percentage in the big leagues.
• Kody Clemens has racked up 117 hits, a team-best for the Twins.
• Luke Keaschall has a .367 on-base percentage to pace his team.

Yankees vs Twins Head to Head

• 9/14/2026: 8-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/5/2026: 6-1 MIN (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/4/2026: 11-4 MIN (Favorite: Yankees, Spread: -1.5, Total: 10, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/3/2026: 5-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 9/17/2025: 10-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 9/16/2025: 10-9 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/15/2025: 7-0 MIN (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 8/12/2025: 9-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/11/2025: 6-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/6/2024: 8-5 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)

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