Cardinals vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 9:12 p.m.

The St. Louis Cardinals versus the San Francisco Giants is on the MLB schedule for Wednesday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Giants Game Info

• St. Louis Cardinals (75-76) vs. San Francisco Giants (62-89)
• Date: Wednesday, September 16, 2026
• Time: 1:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and NBCS-BA

Cardinals vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-156) | SF: (+132)
• Spread: STL: -1.5 (+142) | SF: +1.5 (-172)
• Total: 8.5 -- Over: (+102) | Under: (-124)

Cardinals vs Giants Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 5-14, 5.53 ERA vs Anthony Molina (Giants) - 3-1, 5.24 ERA

The probable pitchers are Matthew Liberatore (5-14) for the Cardinals and Anthony Molina (3-1) for the Giants. Liberatore and his team are 14-14-0 ATS this season when he starts. Liberatore's team has won 60% of his starts when they are favored on the moneyline (6-4). The Giants have a 2-1-0 record against the spread in Molina's starts. The Giants have been the moneyline underdog in three of Molina's starts this season, and they went 2-1 in those games.

Cardinals vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (56.5%)

Cardinals vs Giants Moneyline

• San Francisco is the underdog, +132 on the moneyline, while St. Louis is a -156 favorite at home.

Cardinals vs Giants Spread

• The Cardinals are hosting the Giants and are favored by 1.5 runs (+142 to cover) on the runline. San Francisco is -172 to cover.

Cardinals vs Giants Over/Under

• An over/under of 8.5 has been set for Cardinals-Giants on Sept. 16, with the over being +102 and the under -124.

Bet on St. Louis Cardinals vs. San Francisco Giants on FanDuel today!

Cardinals vs Giants Betting Trends

• The Cardinals have been victorious in 27, or 55.1%, of the 49 contests they have been chosen as favorites in this season.
• St. Louis has not lost in three games this year when favored by -156 or better on the moneyline.
• The Cardinals' games have gone over the total in 67 of their 147 opportunities.
• The Cardinals have posted a record of 80-67-0 against the spread this season.
• The Giants have been the moneyline underdog 102 total times this season. They've gone 37-65 in those games.
• San Francisco is 14-20 (winning 41.2% of its games) when it has played as a moneyline underdog of +132 or longer.
• The Giants have had an over/under set by bookmakers 148 times, and have combined with opponents to go over the total in 72 of those games (72-66-10).
• The Giants are 71-77-0 against the spread this season.

Cardinals Player Leaders

• Alec Burleson has an OPS of .819, fueled by an OBP of .352 and a team-best slugging percentage of .467 this season. He has a .285 batting average.
• Among qualifying hitters, he ranks 17th in batting average, his on-base percentage ranks 40th, and he is 33rd in slugging.
• Burleson has recorded a base hit in two games in a row. In his last five games he is batting .313 with two doubles, four walks and six RBIs.
• Jordan Walker has 160 hits, which leads St. Louis batters this season. He's batting .281 with 61 extra-base hits. He's also slugging .487 with an on-base percentage of .337.
• Among qualifying hitters, his batting average places him 22nd, his on-base percentage 59th, and his slugging percentage 22nd.
• Ivan Herrera has 138 hits this season and a team-best OBP of .356.
• Nathan Church is batting .252 with a .297 OBP and 50 RBI for St. Louis this season.

Giants Player Leaders

• Jung Hoo Lee has a .400 slugging percentage, which leads the Giants. He's batting .277 with an on-base percentage of .319.
• Including all qualified hitters in the majors, he is 31st in batting average, 88th in on-base percentage and 89th in slugging percentage.
• Bryce Eldridge is hitting .269 with 22 doubles, 16 home runs and 56 walks. He's slugging .454 with an on-base percentage of .361.
• Drew Gilbert is batting .234 with 14 doubles, three triples, nine home runs and 36 walks.
• Christian Koss is batting .229 with five doubles, four home runs and nine walks.

Cardinals vs Giants Head to Head

• 9/14/2026: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/9/2026: 7-6 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 9/8/2026: 2-1 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/7/2026: 5-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/24/2025: 4-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/23/2025: 9-8 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/22/2025: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/7/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 3-2 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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