Yankees vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 4:18 a.m.

Thursday's slate in the MLB includes a matchup between the New York Yankees and the Boston Red Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Yankees vs Red Sox Game Info

• New York Yankees (69-57) vs. Boston Red Sox (68-59)
• Date: Thursday, August 21, 2025
• Time: 7:15 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: FOX

Yankees vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-138) | BOS: (+118)
• Spread: NYY: -1.5 (+152) | BOS: +1.5 (-184)
• Total: 8.5 -- Over: (-100) | Under: (-122)

Yankees vs Red Sox Probable Starting Pitchers

Probable Pitchers: Luis Gil (Yankees) - 1-1, 5.14 ERA vs Lucas Giolito (Red Sox) - 8-2, 3.63 ERA

The probable starters are Luis Gil (1-1) for the Yankees and Lucas Giolito (8-2) for the Red Sox. Gil's team is 1-2-0 against the spread this season in his starts. Gil's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 2-1. The Red Sox have a 13-6-0 ATS record in Giolito's 19 starts that had a set spread. The Red Sox are 6-4 in Giolito's 10 starts this season that they were the underdog on the moneyline.

Yankees vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (61%)

Yankees vs Red Sox Moneyline

• Boston is a +118 underdog on the moneyline, while New York is a -138 favorite at home.

Yankees vs Red Sox Spread

• The Yankees are hosting the Red Sox and are favored by 1.5 runs (+152 to cover) on the runline. Boston is -184 to cover.

Yankees vs Red Sox Over/Under

• The over/under for the Yankees versus Red Sox contest on Aug. 21 has been set at 8.5, with -100 odds on the over and -122 odds on the under.

Bet on New York Yankees vs. Boston Red Sox on FanDuel today!

Yankees vs Red Sox Betting Trends

• The Yankees have been favorites in 104 games this season and have come away with the win 60 times (57.7%) in those contests.
• New York has a record of 47-29 in contests when bookmakers favor them by -138 or more on the moneyline.
• The Yankees and their opponents have gone over the total this season in 58 of their 124 opportunities.
• The Yankees have posted a record of 55-69-0 against the spread this season.
• The Red Sox have been the moneyline underdog 44 total times this season. They've gone 20-24 in those games.
• When it has played as a moneyline underdog with odds of +118 or longer, Boston has gone 8-13 (38.1%).
• The Red Sox have had an over/under set by oddsmakers 126 times, and have combined with opponents to go over the total in 61 of those games (61-60-5).
• The Red Sox have put together a 69-57-0 record against the spread this season.

Yankees Player Leaders

• Aaron Judge has 139 hits and an OBP of .445 to go with a slugging percentage of .684. All three of those stats rank first among New York hitters this season. He has a .330 batting average, as well.
• Among qualified hitters in the majors, he ranks first in batting average, first in on-base percentage, and first in slugging.
• Cody Bellinger is hitting .272 with 20 doubles, five triples, 24 home runs and 37 walks, while slugging .498 with an on-base percentage of .325.
• Among qualified hitters, he is 44th in batting average, 86th in on-base percentage and 21st in slugging percentage.
• Bellinger heads into this game looking to extend his three-game hit streak. In his last five games he is batting .333 with three home runs, a walk and seven RBIs.
• Trent Grisham has 93 hits this season and has a slash line of .249/.353/.464.
• Anthony Volpe has been key for New York with 95 hits, an OBP of .280 plus a slugging percentage of .409.

Red Sox Player Leaders

• Jarren Duran has a .336 on-base percentage and a .451 slugging percentage, both team-best numbers for the Red Sox. He's batting .261.
• Including all the qualified hitters in the majors, he ranks 71st in batting average, 64th in on-base percentage and 62nd in slugging percentage.
• Trevor Story is batting .259 with 21 doubles, 19 home runs and 25 walks. He's slugging .423 with an on-base percentage of .302.
• Including all qualified players, he ranks 78th in batting average, 127th in on-base percentage and 86th in slugging percentage.
• Ceddanne Rafaela is hitting .252 with 25 doubles, three triples, 14 home runs and 21 walks.
• Alex Bregman is batting .298 with 23 doubles, 16 home runs and 36 walks.

Yankees vs Red Sox Head to Head

• 6/15/2025: 2-0 BOS (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/14/2025: 4-3 BOS (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/13/2025: 2-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/8/2025: 11-7 BOS (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 6/7/2025: 10-7 BOS (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2025: 9-6 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/15/2024: 5-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/14/2024: 7-1 BOS (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/13/2024: 5-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/12/2024: 2-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)

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