Orioles vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 4:19 a.m.

The Baltimore Orioles versus the Houston Astros is on the MLB schedule for Thursday.

We've got you covered, in terms of the most important information regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Astros Game Info

• Baltimore Orioles (59-67) vs. Houston Astros (69-58)
• Date: Thursday, August 21, 2025
• Time: 7:15 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: FOX

Orioles vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-118) | HOU: (-100)
• Spread: BAL: +1.5 (-205) | HOU: -1.5 (+168)
• Total: 9 -- Over: (+104) | Under: (-128)

Orioles vs Astros Probable Starting Pitchers

Probable Pitchers: Brandon Young (Orioles) - 1-6, 5.68 ERA vs Jason Alexander (Astros) - 3-1, 4.74 ERA

This contest's pitching matchup is set, as the Orioles will send Brandon Young (1-6) to the mound, while Jason Alexander (3-1) will take the ball for the Astros. Young's team is 5-5-0 against the spread in his starts this season. Young's team is 1-1 this season when he starts and they're favored on the moneyline. The Astros have a 4-2-0 ATS record in Alexander's six starts with a set spread. The Astros were the moneyline underdog for two Alexander starts this season -- they won both.

Orioles vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53.8%)

Orioles vs Astros Moneyline

• Looking at the moneyline for Orioles-Astros, Baltimore is the favorite at -118, and Houston is -100 playing on the road.

Orioles vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Orioles. The Astros are +168 to cover, while the Orioles are -205 to cover as a 1.5-run underdog on the runline.

Orioles vs Astros Over/Under

• An over/under of 9 has been set for Orioles-Astros on Aug. 21, with the over being +104 and the under -128.

Bet on Baltimore Orioles vs. Houston Astros on FanDuel today!

Orioles vs Astros Betting Trends

• The Orioles have been chosen as favorites in 53 games this year and have walked away with the win 24 times (45.3%) in those games.
• This season Baltimore has been victorious 21 times in 44 chances when named as a favorite of at least -118 on the moneyline.
• The Orioles and their opponents have hit the over in 53 of their 123 games with a total set by oddsmakers this season.
• The Orioles are 58-65-0 against the spread in their 123 games that had a posted line this season.
• The Astros are 24-17 in games they were the underdog on the moneyline (winning 58.5% of those games).
• Houston is 17-12 (winning 58.6% of its games) when it has played as a moneyline underdog of -100 or longer.
• The Astros have combined with opponents to go over the total 57 times this season for a 57-65-4 record against the over/under.
• The Astros have collected a 62-64-0 record ATS this season (covering 49.2% of the time).

Orioles Player Leaders

• Gunnar Henderson has 125 hits and an OBP of .353 to go with a slugging percentage of .470. All three of those stats are best among Baltimore hitters this season. He has a .281 batting average, as well.
• Among all qualified batters in the majors, his batting average ranks 27th, his on-base percentage ranks 38th, and he is 44th in slugging.
• Henderson will look for his third straight game with a hit in this matchup. In his last five games he is hitting .222 with a triple, a home run, four walks and six RBIs.
• Jackson Holliday is hitting .248 with 17 doubles, two triples, 15 home runs and 34 walks, while slugging .389 with an on-base percentage of .306.
• He is 104th in batting average, 121st in on-base percentage and 124th in slugging among qualifying batters.
• Jordan Westburg has 78 hits this season and has a slash line of .276/.326/.473.
• Adley Rutschman has been key for Baltimore with 70 hits, an OBP of .310 plus a slugging percentage of .373.

Astros Player Leaders

• Jose Altuve has a slugging percentage of .459, a team-high for the Astros. He's batting .276 with an on-base percentage of .340.
• Including all the qualifying hitters in the big leagues, his batting average places him 38th, his on-base percentage is 55th, and he is 55th in slugging.
• Jeremy Pena has 117 hits with a .368 OBP to pace his team in both. He has a batting average of .310 while slugging .479.
• His batting average ranks fourth among all qualified players, his on-base percentage ranks 17th, and he is 32nd in slugging.
• Yainer Diaz is batting .255 with 16 doubles, a triple, 17 home runs and 17 walks.
• Carlos Correa is batting .278 with 22 doubles, nine home runs and 32 walks.

Orioles vs Astros Head to Head

• 8/17/2025: 12-0 BAL (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/16/2025: 5-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/15/2025: 7-0 BAL (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/25/2024: 6-3 HOU (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/24/2024: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/23/2024: 7-5 BAL (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/22/2024: 6-0 HOU (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/23/2024: 8-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/22/2024: 5-1 HOU (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/21/2024: 14-11 HOU (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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