Yankees vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 3:11 p.m.

The New York Yankees will take on the Tampa Bay Rays in MLB action on Tuesday.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Yankees vs Rays Game Info

• New York Yankees (89-66) vs. Tampa Bay Rays (95-60)
• Date: Tuesday, September 22, 2026
• Time: 7:05 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: TBS, YES, and Rays.TV

Yankees vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-144) | TB: (+122)
• Spread: NYY: -1.5 (+155) | TB: +1.5 (-188)
• Total: 6.5 -- Over: (-124) | Under: (+102)

Yankees vs Rays Probable Starting Pitchers

Probable Pitchers: Max Fried (Yankees) - 5-4, 2.63 ERA vs Drew Rasmussen (Rays) - 15-5, 2.72 ERA

This contest's pitching matchup is set, as the Yankees will send Max Fried (5-4) to the mound, while Drew Rasmussen (15-5) will answer the bell for the Rays. Fried's team is 10-7-0 against the spread in his starts this season. When Fried starts a game and his team is the favorite on the moneyline, they have a record of 10-6. The Rays have a 15-13-0 ATS record in Rasmussen's 28 starts that had a set spread. The Rays have been the underdog on the moneyline in eight of Rasmussen's starts this season, and they went 4-4 in those matchups.

Yankees vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (50.1%)

Yankees vs Rays Moneyline

• Tampa Bay is a +122 underdog on the moneyline, while New York is a -144 favorite at home.

Yankees vs Rays Spread

• The Yankees are hosting the Rays and are favored by 1.5 runs on the spread. The Yankees are +155 to cover the runline, with the Rays being -188.

Yankees vs Rays Over/Under

• Yankees versus Rays, on Sept. 22, has an over/under of 6.5, with the over being -124 and the under +102.

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Yankees vs Rays Betting Trends

• The Yankees have been victorious in 71, or 59.7%, of the 119 contests they have been chosen as favorites in this season.
• This season New York has come away with a win 41 times in 69 chances when named as a favorite of at least -144 on the moneyline.
• The Yankees and their opponents have gone over the total this season in 70 of their 150 opportunities.
• The Yankees have posted a record of 77-73-0 against the spread this season.
• The Rays have been the underdog on the moneyline 44 total times this season. They've gone 24-20 in those games.
• When playing as a moneyline underdog with odds of +122 or longer, Tampa Bay has an 8-3 record (winning 72.7% of its games).
• The Rays have had an over/under set by bookmakers 153 times, and have combined with opponents to go over the total in 71 of those games (71-80-2).
• The Rays have put together an 82-71-0 record against the spread this season (covering 53.6% of the time).

Yankees Player Leaders

• Ben Rice leads New York OPS (.889) this season. He has a .261 batting average, an on-base percentage of .360, and a slugging percentage of .528.
• Among all qualifying hitters, he ranks 61st in batting average, his on-base percentage ranks 28th, and he is fifth in slugging.
• Luis Garcia has 141 hits, which leads New York batters this season. He's batting .281 with 61 extra-base hits. He's also slugging .532 with an on-base percentage of .311.
• Among qualifying hitters, his batting average places him 22nd, his on-base percentage 103rd, and his slugging percentage third.
• Cody Bellinger is batting .270 with a .435 slugging percentage and 71 RBI this year.
• Jose Caballero is batting .236 with a .292 OBP and 51 RBI for New York this season.

Rays Player Leaders

• Junior Caminero has racked up 164 hits, a team-high for the Rays. He's batting .277 and slugging .529 with an on-base percentage of .363.
• Including all the qualifying hitters in MLB, he is 28th in batting average, 24th in on-base percentage and fourth in slugging percentage.
• Caminero hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .222 with two doubles, four walks and an RBI.
• Yandy Diaz is slugging .449 to lead his team. He has a batting average of .292 with an on-base percentage of .358.
• His batting average ranks ninth among all qualified players, his on-base percentage is 33rd, and he is 48th in slugging.
• Liam Hicks has a team-high .371 on-base percentage.
• Chandler Simpson is batting .309 with 16 doubles, six triples and 26 walks.

Yankees vs Rays Head to Head

• 7/9/2026: 12-4 NYY (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/8/2026: 3-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 7/7/2026: 6-4 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/6/2026: 5-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/24/2026: 2-0 NYY (Favorite: Yankees, Spread: -1.5, Total: 7, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/22/2026: 4-2 TB (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/12/2026: 5-4 TB (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/11/2026: 5-4 TB (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 4/10/2026: 5-3 TB (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/20/2025: 6-4 NYY (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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