MLB Predictions Today: 3 MLB Best Bets and Picks for Tuesday, September 22, 2026

Today’s Best MLB Picks in Summary

• Andre Pallante Over 15.5 Outs (+100)
• Mickey Moniak to Record an RBI (+150)
• Mike Trout to Hit a Home Run (+340)

Baseball has you covered if you want a large inventory of options to bet.

From moneylines to player props to NRFI wagers, we have plenty of ways each day to bet the long, arduous MLB schedule.

Using the MLB odds at FanDuel Sportsbook, what are the best MLB bets for today?

This article includes some of the top bets from our other MLB content. All MLB odds via FanDuel, and they may change after this article is published.

MLB Picks and Predictions for Today

Andre Pallante Over 15.5 Outs Recorded (+100)

Cardinals vs. Pirates, 6:41 p.m. ET

Andre Pallante to go over 15.5 outs is my favorite player prop today.

Pallante is a ground-ball pitcher who thrives on inducing weak contact (55.5% ground-ball rate) and limiting walks (7.5% walk rate) rather than racking up whiffs (16.5% K rate). While that adds some volatility to his profile, it can also help him record quick outs.

He’s been remarkably durable and consistent for the St. Louis Cardinals in 2026, pitching at least five innings in 16 straight outings. In that span, he’s gone over 15.5 outs in 12 of 16 games. The likely reason we’re getting him at even money to do it today is that three of the four times he’s gone under 15.5 outs have come over his past three starts.

But I really like his matchup with a slumping Pittsburgh Pirates offense, one that sits 23rd in second-half wOBA (.305). He faced Pittsburgh back on April 29th and completed six innings. As long as the batted-ball gods cooperate, Pallante can get at least 16 outs on Tuesday.

Mickey Moniak to Record an RBI (+150)

Diamondbacks vs. Rockies, 8:41 p.m. ET

Mickey Moniak has some drastic home/road splits, which isn’t shocking given that he plays his home games at Coors. But his home output coupled with a date against RHP Michael Soroka puts me on Moniak to drive in a run today at these odds.

Moniak has slugged his way to a .388 wOBA at home, compared to a .245 wOBA on the road. He’s also much better versus righties (.344 wOBA) than southpaws (.251 wOBA).

Soroka’s 4.21 expected ERA is quite a bit worse than his 3.45 actual ERA. He’s got a meh 9.6% swinging-strike rate overall while lefty bats are striking out only 20.0% of the time against him.

Moniak will likely hit fifth or six in the Colorado Rockies‘ lineup, which is a good spot for RBI chances. On a night when Colorado is listed at -104 odds to go over 4.5 runs, Moniak can get in on the fun.

Home Run Prediction: Mike Trout (+340)

Angels at Athletics, 9:41 p.m. ET

Mike Trout gets a big park-factor boost tonight at Sutter Health Park, and he’s on my HR radar.

The A’s are starting Brady Basso, a lefty. Basso has pitched only 40.0 MLB innings this campaign, and he’s not missing bats, recording a lowly 15.7% strikeout rate. He’s allowed a .363 wOBA and 38.9% hard-hit rate to right-handed hitters.

Basso has not pitched more than four innings in a game at the MLB level this year, so the A’s will have to turn to their bullpen for a big chunk of tonight’s game. That’s good for Trout as the Athletics bullpen has the fifth-worst xFIP in the second half.

Trout has a .378 expected wOBA this season, and he’s been much more productive on the road (.395 wOBA) than at home (.312 wOBA). Sutter Health Park has actually been the best venue for dingers this season, so Trout checks a lot of boxes.

MLB Betting Frequently Asked Questions

What are MLB player prop bets?

MLB player prop bets are wagers on specific statistical outcomes tied to individual players during a game — not on which team wins or loses. You might bet on how many strikeouts a starting pitcher records, whether a shortstop gets a hit, or how many total bases an outfielder accumulates.

Because they are isolated to a single player's performance, props let you apply focused knowledge about matchups, recent form, and ballpark conditions rather than predicting the full game result.

What types of MLB player props are available?

FanDuel offers a wide menu of MLB props. The most common categories include:

• Pitcher strikeouts
• Batter hits
• Home runs
• Total bases
• RBIs
• Stolen bases
• Pitcher outs recorded

What does +310 mean on an MLB home run prop bet?

A +310 line means a $100 bet returns $310 in profit if the player homers. You can bet any amount — a $10 bet at +310 returns $31 in profit. The number reflects the implied probability the sportsbook assigns to the event (roughly 24% for +310 odds).

What does "total bases" mean as a prop bet?

The total bases prop counts the bases a batter earns from hits in a single game:

• Single = 1 base
• Double = 2 bases
• Triple = 3 bases
• Home run = 4 bases

Walks, hit-by-pitches, and stolen bases do not count. A typical total bases line is set at 1.5 or 2.5. Betting over 1.5 means you need at least a double, or two singles.

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Which MLB bets stand out to you today? Check out FanDuel Sportsbook's MLB odds to see the full menu of options.

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The above author is a FanDuel employee and is not eligible to compete in public daily fantasy contests or place sports betting wagers on FanDuel. The advice provided by the author does not necessarily represent the views of FanDuel. Taking the author’s advice will not guarantee a successful outcome. You should use your own judgment when participating in daily fantasy contests or placing sports wagers.