Yankees vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 2:11 a.m.

The MLB slate on Monday includes the New York Yankees taking on the Cleveland Guardians.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Yankees vs Guardians Game Info

• New York Yankees (14-8) vs. Cleveland Guardians (12-9)
• Date: Monday, April 21, 2025
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and YES

Yankees vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-124) | CLE: (+106)
• Spread: NYY: -1.5 (+136) | CLE: +1.5 (-164)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Yankees vs Guardians Probable Starting Pitchers

Probable Pitchers: Clarke Schmidt (Yankees) - 0-0, 4.76 ERA vs Gavin Williams (Guardians) - 1-1, 4.58 ERA

This contest's pitching matchup is set, as the Yankees will send Clarke Schmidt to the mound, while Gavin Williams (1-1) will answer the bell for the Guardians. Schmidt and his team failed to cover the spread in his only opportunity this season as a starter. Schmidt's team won his only start as a favorite this season. The Guardians have gone 2-2-0 against the spread when Williams starts. The Guardians were the underdog on the moneyline for two Williams starts this season -- they lost both.

Yankees vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (54.3%)

Yankees vs Guardians Moneyline

• Cleveland is the underdog, +106 on the moneyline, while New York is a -124 favorite despite being on the road.

Yankees vs Guardians Spread

• The Guardians are hosting the Yankees, and are +1.5 on the runline. The Guardians are +136 to cover the spread, and the Yankees are -164.

Yankees vs Guardians Over/Under

• A total of 8.5 runs has been set for the Yankees-Guardians game on April 21, with the over available at -105 and the under at -115.

Bet on New York Yankees vs. Cleveland Guardians on FanDuel today!

Yankees vs Guardians Betting Trends

• The Yankees have been chosen as favorites in 18 games this year and have walked away with the win 13 times (72.2%) in those games.
• New York has a record of 12-4 when favored by -124 or more this year.
• The Yankees and their opponents have gone over the total this season in 11 of their 22 opportunities.
• The Yankees have posted a record of 11-11-0 against the spread this season.
• The Guardians have compiled a 5-7 record in games they were the underdog on the moneyline (winning 41.7% of those games).
• When playing as a moneyline underdog with odds of +106 or longer, Cleveland has a record of 3-5 (37.5%).
• The Guardians have played in 21 games with a set over/under, and have combined with their opponents to go over the total 11 times (11-9-1).
• The Guardians have covered 42.9% of their games this season, going 9-12-0 ATS.

Yankees Player Leaders

• Aaron Judge leads New York in OBP (.495), slugging percentage (.707) and total hits (32) this season. He has a .390 batting average.
• Among qualified batters in baseball, his batting average ranks first, his on-base percentage ranks first, and he is second in slugging.
• Judge has picked up at least one hit in two games in a row. In his last five games he is batting .421 with a double, a home run, three walks and five RBI.
• Ben Rice is batting .292 with three doubles, a triple, five home runs and 10 walks. He's slugging .600 with an on-base percentage of .403.
• Among all qualified, he ranks 40th in batting average, 19th in on-base percentage and 11th in slugging percentage.
• Trent Grisham has collected 16 base hits, an OBP of .393 and a slugging percentage of .700 this season.
• Grisham takes a three-game hitting streak into this game. In his last five games he is hitting .267 with two home runs, two walks and three RBI.
• Anthony Volpe is batting .213 with a .304 OBP and 15 RBI for New York this season.
• Volpe has hit safely in two games in a row. During his last five outings he is hitting .200 with two doubles, a walk and two RBI.

Guardians Player Leaders

• Steven Kwan has put up a .385 on-base percentage and a .494 slugging percentage, both team-best numbers for the Guardians. He's batting .325.
• Including all qualifying hitters, he is 13th in batting average, while his on-base percentage ranks 30th and he is 36th in slugging.
• Kwan takes a four-game hitting streak into this game. During his last five outings he is batting .300 with a double, a home run, two walks and three RBI.
• Jose Ramirez is batting .268 with four doubles, four home runs and eight walks. He's slugging .493 with an on-base percentage of .333.
• His batting average ranks 65th among all qualified players, his on-base percentage is 74th, and he is 38th in slugging.
• Kyle Manzardo paces the Guardians with 14 hits.
• Gabriel Arias has three doubles, four home runs and five walks while batting .277.

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