Yankees vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 3

Odds updated as of 10:12 a.m.

On Wednesday in MLB, the New York Yankees are up against the Houston Astros.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Yankees vs Astros Game Info

• New York Yankees (77-61) vs. Houston Astros (76-63)
• Date: Wednesday, September 3, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: MLB Network, SCHN, and Amazon Prime Video

Yankees vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-126) | HOU: (+108)
• Spread: NYY: -1.5 (+126) | HOU: +1.5 (-152)
• Total: 9 -- Over: (-106) | Under: (-114)

Yankees vs Astros Probable Starting Pitchers

Probable Pitchers: Will Warren (Yankees) - 8-6, 4.30 ERA vs Jason Alexander (Astros) - 4-1, 4.61 ERA

The Yankees will give the ball to Will Warren (8-6, 4.30 ERA), who is eyeing win No. 9 on the season, and the Astros will counter with Jason Alexander (4-1, 4.61 ERA). Warren's team is 12-16-0 against the spread this season in his starts. Warren's team has been victorious in 65.2% of the games he's started as the moneyline favorite with a record of 15-8. When Alexander starts, the Astros are 5-3-0 against the spread. The Astros were named the moneyline underdog for three Alexander starts this season -- they won all of the games.

Yankees vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (55.1%)

Yankees vs Astros Moneyline

• The Yankees vs Astros moneyline has New York as a -126 favorite, while Houston is a +108 underdog at home.

Yankees vs Astros Spread

• The Astros are +1.5 on the run line against the Yankees. The Astros are -152 to cover, and the Yankees are +126.

Yankees vs Astros Over/Under

• A combined run total of 9 has been set for Yankees-Astros on Sept. 3, with the over at -106 and the under at -114.

Bet on New York Yankees vs. Houston Astros on FanDuel today!

Yankees vs Astros Betting Trends

• The Yankees have won in 68, or 59.1%, of the 115 contests they have been named as odds-on favorites in this year.
• New York has a record of 63-41 when favored by -126 or more this year.
• Contests with the Yankees have gone over the total set by bookmakers in 66 of 136 chances this season.
• The Yankees have posted a record of 63-73-0 against the spread this season.
• The Astros have won 26 of the 45 games they were the moneyline underdog this season (57.8%).
• Houston has a record of 16-12 when it has played as a moneyline underdog with odds of +108 or longer (57.1%).
• In the 138 games oddsmakers have set an over/under for the Astros, they have combined with opponents to go over the total 62 times (62-72-4).
• The Astros have gone 68-70-0 against the spread this season.

Yankees Player Leaders

• Aaron Judge has 151 hits and an OBP of .442 to go with a slugging percentage of .671. All three of those stats rank first among New York hitters this season. He has a .325 batting average, as well.
• He ranks first in batting average, first in on-base percentage, and first in slugging among qualified batters in the majors.
• Judge will look for his fourth straight game with a hit in this matchup. During his last five outings he is hitting .368 with a double, two home runs, six walks and two RBIs.
• Cody Bellinger is batting .279 with 23 doubles, five triples, 26 home runs and 42 walks. He's slugging .501 with an on-base percentage of .332.
• He is 27th in batting average, 73rd in on-base percentage and 20th in slugging in the majors.
• Bellinger enters this matchup looking to extend his three-game hit streak. In his last five games he is hitting .273 with two doubles, a home run, two walks and four RBIs.
• Trent Grisham is batting .248 with a .484 slugging percentage and 61 RBI this year.
• Jazz Chisholm has been key for New York with 92 hits, an OBP of .342 plus a slugging percentage of .505.

Astros Player Leaders

• Jose Altuve has a team-high .456 slugging percentage. He's batting .272 with an on-base percentage of .334.
• Including all the qualifying players in the big leagues, he ranks 39th in batting average, 68th in on-base percentage and 54th in slugging percentage.
• Jeremy Pena leads his team with 130 hits and a .365 OBP. He has a batting average of .304 while slugging .473.
• Including all qualifying hitters, he ranks fifth in batting average, 20th in on-base percentage and 39th in slugging percentage.
• Yainer Diaz is batting .253 with 18 doubles, a triple, 18 home runs and 19 walks.
• Christian Walker is hitting .235 with 21 doubles, a triple, 21 home runs and 38 walks.

Yankees vs Astros Head to Head

• 9/2/2025: 7-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/10/2025: 7-1 HOU (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/9/2025: 5-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/8/2025: 5-3 HOU (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/9/2024: 4-3 HOU (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/8/2024: 9-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/7/2024: 10-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 3/31/2024: 4-3 NYY (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 3/30/2024: 5-3 NYY (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 3/29/2024: 7-1 NYY (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!