White Sox vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 12:12 a.m.

The Chicago White Sox will face the San Francisco Giants in MLB action on Saturday.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

White Sox vs Giants Game Info

• Chicago White Sox (25-24) vs. San Francisco Giants (20-30)
• Date: Saturday, May 23, 2026
• Time: 4:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and CHSN

White Sox vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-112) | SF: (-104)
• Spread: CHW: -1.5 (+152) | SF: +1.5 (-184)
• Total: 7.5 -- Over: (+100) | Under: (-122)

White Sox vs Giants Probable Starting Pitchers

Probable Pitchers: Erick Fedde (White Sox) - 0-4, 4.30 ERA vs Adrian Houser (Giants) - 2-4, 5.25 ERA

The White Sox will give the ball to Erick Fedde (0-4, 4.30 ERA), who is eyeing win No. 1 on the season, and the Giants will counter with Adrian Houser (2-4, 5.25 ERA). Fedde and his team are 4-3-0 ATS this season when he starts. Fedde has yet to start a game this season when his team was the moneyline favorite. The Giants have a 3-6-0 record against the spread in Houser's starts. The Giants are 2-6 in Houser's eight starts this season that they were the moneyline underdog.

White Sox vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (57.5%)

White Sox vs Giants Moneyline

• The White Sox vs Giants moneyline has Chicago as a -112 favorite, while San Francisco is a -104 underdog at home.

White Sox vs Giants Spread

• The Giants are at +1.5 on the runline against the White Sox. The Giants are -184 to cover the spread, and the White Sox are +152.

White Sox vs Giants Over/Under

• White Sox versus Giants, on May 23, has an over/under of 7.5, with the over being +100 and the under -122.

Bet on Chicago White Sox vs. San Francisco Giants on FanDuel today!

White Sox vs Giants Betting Trends

• The White Sox have been victorious in one of the four contests they have been chosen as favorites in this season.
• This season Chicago has been victorious one time in four chances when named as a favorite of at least -112 on the moneyline.
• Contests with the White Sox have gone over the total set by bookmakers in 26 of 47 chances this season.
• The White Sox are 28-19-0 against the spread in their 47 games that had a posted line this season.
• The Giants have won 13 of the 36 games they were the moneyline underdog this season (36.1%).
• San Francisco is 13-19 (winning 40.6% of its games) when playing as a moneyline underdog of -104 or longer.
• The Giants have had an over/under set by bookmakers 50 times, and have combined with opponents to go over the total in 22 of those games (22-25-3).
• The Giants have gone 20-30-0 ATS this season.

White Sox Player Leaders

• Miguel Vargas is hitting .237 with seven doubles, a triple, 11 home runs and 31 walks. He has an on-base percentage of .367 while slugging .485.
• He is 107th in batting average, 32nd in on-base percentage, and 29th in slugging among qualified hitters in MLB.
• Munetaka Murakami leads the White Sox in OBP (.382) and total hits (42) this season. He's batting .244 while slugging .552.
• Among qualifiers, he is 97th in batting average, 20th in on-base percentage and 11th in slugging percentage.
• Colson Montgomery is batting .223 with a .491 slugging percentage and 31 RBI this year.
• Chase Meidroth leads Chicago with a slugging percentage of .374, fueled by 12 extra-base hits.
• Meidroth takes a two-game hitting streak into this game. During his last five outings he is batting .188 with two walks and an RBI.

Giants Player Leaders

• Luis Arraez has put up an on-base percentage of .358 and a slugging percentage of .422. Both lead the Giants. He's batting .319.
• Including all the qualified hitters in MLB, he ranks eighth in batting average, 44th in on-base percentage and 74th in slugging percentage.
• Casey Schmitt has collected 46 hits to lead his team. He has a batting average of .293 while slugging .529 with an on-base percentage of .337.
• Including all qualifying hitters, he ranks 22nd in batting average, 72nd in on-base percentage and 15th in slugging percentage.
• Jung Hoo Lee has 10 doubles, a triple, three home runs and 10 walks while hitting .268.
• Rafael Devers is batting .246 with 12 doubles, six home runs and 13 walks.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!