Phillies vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 1:12 a.m.

On Saturday in MLB, the Philadelphia Phillies are playing the Cleveland Guardians.

We've got you covered, in terms of the vital information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Phillies vs Guardians Game Info

• Philadelphia Phillies (25-26) vs. Cleveland Guardians (31-22)
• Date: Saturday, May 23, 2026
• Time: 4:05 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and CleGuardians.TV

Phillies vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-198) | CLE: (+166)
• Spread: PHI: -1.5 (+108) | CLE: +1.5 (-130)
• Total: 7 -- Over: (-122) | Under: (+100)

Phillies vs Guardians Probable Starting Pitchers

Probable Pitchers: Zack Wheeler (Phillies) - 3-0, 1.99 ERA vs Slade Cecconi (Guardians) - 3-4, 5.16 ERA

The probable pitchers are Zack Wheeler (3-0) for the Phillies and Slade Cecconi (3-4) for the Guardians. Wheeler's team is 3-2-0 against the spread in his starts this season. Wheeler's team has won each of the three games he's started as the moneyline favorite. The Guardians are 3-6-0 ATS in Cecconi's nine starts that had a set spread. The Guardians have been the moneyline underdog in seven of Cecconi's starts this season, and they went 2-5 in those games.

Phillies vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (66.2%)

Phillies vs Guardians Moneyline

• Cleveland is a +166 underdog on the moneyline, while Philadelphia is a -198 favorite at home.

Phillies vs Guardians Spread

• The Guardians are at the Phillies, and are +1.5 on the runline. The Guardians are +108 to cover the spread, and the Phillies are -130.

Phillies vs Guardians Over/Under

• Phillies versus Guardians on May 23 has an over/under of 7 runs, with the odds on the over -122 and the under set at +100.

Bet on Philadelphia Phillies vs. Cleveland Guardians on FanDuel today!

Phillies vs Guardians Betting Trends

• The Phillies have won in 20, or 54.1%, of the 37 contests they have been named as odds-on favorites in this year.
• This season Philadelphia has been victorious four times in five chances when named as a favorite of at least -198 on the moneyline.
• The Phillies and their opponents have gone over in 24 of their 51 games with a total set by sportsbooks this season.
• The Phillies have an against the spread mark of 15-36-0 in 51 games with a line this season.
• The Guardians are 13-10 in games they were listed as the moneyline underdog (winning 56.5% of those games).
• Cleveland has played as a moneyline underdog of +166 or longer in just two games this season, which it split 1-1.
• The Guardians have played in 50 games with a set over/under, and have combined with opponents to go over the total 25 times (25-25-0).
• The Guardians have covered 54% of their games this season, going 27-23-0 against the spread.

Phillies Player Leaders

• Bryce Harper has 49 hits this season and a team-best OBP of .357. He has a .266 batting average and a slugging percentage of .527.
• He ranks 60th in batting average, 46th in on-base percentage, and 16th in slugging among qualified hitters in baseball.
• Kyle Schwarber leads Philadelphia in total hits (41) this season while batting .225 with 29 extra-base hits. He's slugging .610 with an on-base percentage of .350.
• Among all qualified, he is 129th in batting average, 56th in on-base percentage and second in slugging percentage.
• Trea Turner has 48 hits this season and has a slash line of .234/.288/.351.
• Brandon Marsh leads Philadelphia in slugging percentage (.462) thanks to 14 extra-base hits.
• Marsh brings a two-game hitting streak into this game. During his last five outings he is hitting .267 with a double.

Guardians Player Leaders

• Jose Ramirez is hitting .236 with 11 doubles, eight home runs and 37 walks. He's slugging .415 with an on-base percentage of .359.
• Including all the qualifying hitters in the majors, his batting average is 109th, his on-base percentage is 42nd, and he is 80th in slugging.
• Ramirez heads into this matchup on a three-game hitting streak. During his last five outings he is hitting .300 with two doubles, a home run, two walks and five RBIs.
• Chase DeLauter has 10 doubles, a triple, seven home runs and 24 walks while batting .266. He's slugging .457 with an on-base percentage of .352.
• Including all qualifying hitters, he is 60th in batting average, 54th in on-base percentage and 50th in slugging percentage.
• Brayan Rocchio has accumulated a .376 on-base percentage and a .418 slugging percentage, both team-best numbers for the Guardians.
• Angel Martinez has collected 41 hits to pace his team.

Phillies vs Guardians Head to Head

• 5/22/2026: 1-0 CLE (Favorite: Phillies, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 5/11/2025: 3-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/10/2025: 7-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/9/2025: 6-0 CLE (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/28/2024: 4-3 CLE (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/27/2024: 8-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/26/2024: 3-1 CLE (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 7/23/2023: 8-5 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2023: 1-0 CLE (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/21/2023: 6-5 CLE (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)

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