White Sox vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 1

Odds updated as of 2:12 a.m.

The MLB slate on Tuesday includes the Chicago White Sox taking on the Houston Astros.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

White Sox vs Astros Game Info

• Chicago White Sox (72-65) vs. Houston Astros (70-68)
• Date: Tuesday, September 1, 2026
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and CHSN

White Sox vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-112) | HOU: (-104)
• Spread: CHW: -1.5 (+146) | HOU: +1.5 (-176)
• Total: 8.5 -- Over: (-104) | Under: (-118)

White Sox vs Astros Probable Starting Pitchers

Probable Pitchers: Sean Burke (White Sox) - 7-6, 3.32 ERA vs Ronel Blanco (Astros) - 0-1, 7.71 ERA

The probable starters are Sean Burke (7-6) for the White Sox and Ronel Blanco (0-1) for the Astros. Burke's team is 12-11-0 against the spread this season in his starts. Burke's team has won 75% of his starts when they are favored on the moneyline (6-2). When Blanco starts, the Astros are 3-1-0 against the spread. The Astros have a 2-1 record in Blanco's three starts this season when they were the moneyline underdog.

White Sox vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (52.7%)

White Sox vs Astros Moneyline

• The moneyline numbers for White Sox vs. Astros reveal Chicago as the favorite (-112) and Houston as the underdog (-104) despite being the home team.

White Sox vs Astros Spread

• The Astros are at +1.5 on the runline against the White Sox. The Astros are -176 to cover the spread, and the White Sox are +146.

White Sox vs Astros Over/Under

• A total of 8.5 runs has been set for the White Sox-Astros game on Sept. 1, with the over available at -104 and the under at -118.

Bet on Chicago White Sox vs. Houston Astros on FanDuel today!

White Sox vs Astros Betting Trends

• The White Sox have won in 16, or 57.1%, of the 28 contests they have been named as odds-on favorites in this year.
• This year Chicago has won 15 of 26 games when listed as at least -112 on the moneyline.
• The White Sox's games have gone over the total in 75 of their 134 opportunities.
• The White Sox are 78-56-0 against the spread in their 134 games with a line set by sportsbooks this season.
• The Astros have won 52.1% of the games this season they were the moneyline underdog (38-35).
• Houston is 35-30 (winning 53.8% of its games) when playing as a moneyline underdog of -104 or longer.
• The Astros have combined with opponents to go over the total 72 times this season for a 72-59-7 record against the over/under.
• The Astros have a 67-71-0 record ATS this season (covering 48.6% of the time).

White Sox Player Leaders

• Miguel Vargas is batting .249 with 30 doubles, a triple, 29 home runs and 85 walks. He has an on-base percentage of .363 and a slugging percentage of .488.
• Among all qualified hitters in the majors, his batting average ranks 83rd, his on-base percentage ranks 26th, and he is 24th in slugging.
• Vargas hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .278 with five walks and an RBI.
• Chase Meidroth has an OPS of .744, fueled by an OBP of .346 and a team-best slugging percentage of .398 this season. He's batting .271.
• Among qualified hitters, his batting average ranks him 43rd, his on-base percentage 48th, and his slugging percentage 94th.
• Sam Antonacci has 108 hits this season and a team-best OBP of .366.
• Antonacci brings a two-game hitting streak into this matchup. In his last five games he is batting .294 with a double, three walks and two RBIs.
• Tristan Peters has 12 home runs, 52 RBI and a batting average of .278 this season.

Astros Player Leaders

• Yordan Alvarez has an on-base percentage of .432, a slugging percentage of .605, and has 155 hits, all club-bests for the Astros (while batting .317).
• Including all the qualified hitters in MLB, his batting average places him first, his on-base percentage ranks first, and he is first in slugging.
• Isaac Paredes is hitting .256 with 23 doubles, a triple, 17 home runs and 59 walks. He's slugging .416 with an on-base percentage of .355.
• He is currently 66th in batting average, 37th in on-base percentage and 77th in slugging percentage among all qualifying hitters.
• Christian Walker is hitting .229 with 25 doubles, a triple, 24 home runs and 44 walks.
• Jeremy Pena has 16 doubles, a triple, 17 home runs and 22 walks while batting .284.

White Sox vs Astros Head to Head

• 8/31/2026: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +118)
• 7/26/2026: 12-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/25/2026: 4-1 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/10/2025: 4-2 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/4/2025: 5-4 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/3/2025: 8-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 5/2/2025: 7-3 CHW (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -240, Underdog Moneyline: +198)

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