Villanova vs Louisville Prediction, College Football Picks, Odds & Best Bets Tonight

College Football Betting Picks in Summary

• Louisville -37.5
• Over 56.5
• Isaac Brown Over 96.5 Rushing Yards

Villanova travels to Louisville Thursday night in one of the widest lines on the entire college football board — a 37.5-point spread with no moneyline even posted, a real sign of just how one-sided the market considers this one.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

College Football Predictions and Picks

Villanova at Louisville (Thu, 7:00 p.m. ET)

Louisville -37.5 (-110)

Louisville's own first-half spread alone sits at -21.5, more than half the full-game number — a genuine sign this one should be well in hand by halftime against an FCS opponent.

Over 56.5 (-110)

Louisville's own projected yardage output (522.5) is enough on its own to comfortably clear this entire total, regardless of how little Villanova manages to produce on the other side.

Isaac Brown Over 96.5 Rushing Yards (-114)

Brown is priced to clear 90 yards on his own at a heavy -140, a genuine sign Louisville plans to establish the ground game early and often against an FCS front seven.