USC vs Louisiana Prediction, Odds, Picks, Best Bets for Week 2 2026

Saturday's slate in college football includes a matchup between the USC Trojans and the Louisiana Ragin' Cajuns.

Get the latest NCAA football odds ahead of this game on FanDuel Sportsbook.

USC vs Louisiana Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: USC: (-10000) | Louisiana: (+2400)
• Spread: USC: -30.5 (-110) | Louisiana: +30.5 (-110)
• Total: 59.5 -- Over: (-110) | Under: (-110)

USC vs Louisiana Betting Trends

• USC has one win against the spread this year.
• USC is winless ATS (0-1) as a 30.5-point favorite or greater this year.
• One of two USC games have hit the over this year.
• Louisiana has but one win versus the spread this season.
• Not one of Louisiana's one games has hit the over in 2026.

USC vs Louisiana Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Trojans win (98.3%)

USC vs Louisiana Point Spread

USC is favored by 30.5 points versus Louisiana. USC is -110 to cover the spread, while Louisiana is -110.

USC vs Louisiana Over/Under

The USC-Louisiana game on Sept. 12 has been given an over/under of 59.5 points. The over is -110 and the under is -110.

USC vs Louisiana Moneyline

Looking at the moneyline for USC-Louisiana, USC is the favorite at -10000, and Louisiana is +2400.

USC vs. Louisiana Points Insights

• The Trojans' average implied point total last season was 8.8 fewer points than their implied total in Saturday's game (36.2 implied points on average compared to 45 implied points in this game).
• The 29.8-point average implied total last season for the Ragin' Cajuns is 14.8 more points than the team's 15-point implied total in this matchup.

USC vs. Louisiana Game Info

• Game day: Saturday, September 12, 2026
• Game time: 11 p.m. ET
• TV channel: BTN
• Location: Los Angeles, California
• Stadium: Los Angeles Memorial Coliseum

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Check out even more in-depth USC vs. Louisiana analysis on FanDuel Research.