Pirates vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 2:12 a.m.

The MLB slate on Thursday includes the Pittsburgh Pirates taking on the Chicago White Sox.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Pirates vs White Sox Game Info

• Pittsburgh Pirates (73-73) vs. Chicago White Sox (75-70)
• Date: Thursday, September 10, 2026
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and SportsNet PT

Pirates vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-110) | CHW: (-106)
• Spread: PIT: -1.5 (+158) | CHW: +1.5 (-192)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Pirates vs White Sox Probable Starting Pitchers

Probable Pitchers: Jared Jones (Pirates) - 3-6, 4.46 ERA vs Hagen Smith (White Sox) - 3-1, 0.56 ERA

The Pirates will give the nod to Jared Jones (3-6) versus the White Sox and Hagen Smith (3-1). When Jones starts, his team is 7-10-0 against the spread this season. Jones' team is 3-4 this season when he starts and they are the moneyline favorite. Smith never pitched as a moneyline underdog a season ago.

Pirates vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (59.1%)

Pirates vs White Sox Moneyline

• The Pirates vs White Sox moneyline has Pittsburgh as a -110 favorite, while Chicago is a -106 underdog at home.

Pirates vs White Sox Spread

• The Pirates are at the White Sox and are favored by 1.5 runs (+158 to cover) on the runline. Chicago is -192 to cover.

Pirates vs White Sox Over/Under

• The Pirates-White Sox game on Sept. 10 has been given an over/under of 7.5 runs. The over is set at -122 and the under at +100.

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Pirates vs White Sox Betting Trends

• The Pirates have been favorites in 76 games this season and have come away with the win 43 times (56.6%) in those contests.
• This season Pittsburgh has come away with a win 43 times in 75 chances when named as a favorite of at least -110 on the moneyline.
• The Pirates' games have gone over the total in 75 of their 144 opportunities.
• The Pirates have an against the spread record of 69-75-0 in 144 games with a line this season.
• The White Sox are 49-52 in games they were listed as the moneyline underdog (winning 48.5% of those games).
• When it has played as a moneyline underdog with odds of -106 or longer, Chicago has a record of 48-53 (47.5%).
• The White Sox have had an over/under set by oddsmakers 142 times, and have combined with opponents to go over the total in 78 of those games (78-63-1).
• The White Sox have covered 57% of their games this season, going 81-61-0 ATS.

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh with an OBP of .371 this season while batting .266 with 82 walks and 98 runs scored. He has a slugging percentage of .429.
• Among all qualifying hitters in the majors, he ranks 51st in batting average, 13th in on-base percentage, and 63rd in slugging.
• Brandon Lowe leads Pittsburgh in total hits (138) this season while batting .259 with 58 extra-base hits. He's slugging .479 with an on-base percentage of .328.
• Among qualifying batters, he is 62nd in batting average, 70th in on-base percentage and 25th in slugging percentage.
• Lowe takes a three-game streak with at least one hit into this matchup. In his last five games he is batting .412 with two walks.
• Nick Gonzales leads Pittsburgh in slugging percentage (.392) powered by 31 extra-base hits.
• Oneil Cruz is batting .270 with a .358 OBP and 60 RBI for Pittsburgh this season.
• Cruz takes a two-game hitting streak into this game. During his last five outings he is batting .263 with a double, a walk and two RBIs.

White Sox Player Leaders

• Miguel Vargas is hitting .249 with 30 doubles, a triple, 30 home runs and 87 walks. He's slugging .479 with an on-base percentage of .359.
• Including all the qualifying players in the majors, his batting average is 78th, his on-base percentage ranks 32nd, and he is 25th in slugging.
• Sam Antonacci paces his team with a .365 OBP. He has a batting average of .267 while slugging .390.
• Including all qualifying players, he ranks 47th in batting average, 23rd in on-base percentage and 100th in slugging percentage.
• Tristan Peters is hitting .283 with 30 doubles, four triples, 12 home runs and 33 walks.
• Chase Meidroth is slugging .391 to lead his team.

Pirates vs White Sox Head to Head

• 9/9/2026: 4-2 PIT (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/8/2026: 9-3 PIT (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/20/2025: 7-2 CHW (Favorite: Pirates, Spread: -1.5, Total: 9.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/19/2025: 10-4 CHW (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/18/2025: 10-1 CHW (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 7/14/2024: 9-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -176, Underdog Moneyline: +148)
• 7/13/2024: 6-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/12/2024: 4-1 PIT (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/9/2023: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/8/2023: 11-5 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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