Twins vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 10:12 p.m.

The Monday schedule in MLB includes a matchup between the Minnesota Twins and the Chicago White Sox.

We've got you covered, in terms of the most important info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Twins vs White Sox Game Info

• Minnesota Twins (26-27) vs. Chicago White Sox (26-26)
• Date: Monday, May 25, 2026
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and Twins.TV

Twins vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-112) | CHW: (-104)
• Spread: MIN: -1.5 (+146) | CHW: +1.5 (-178)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Twins vs White Sox Probable Starting Pitchers

Probable Pitchers: Zebby Matthews (Twins) - 1-1, 1.38 ERA vs Anthony Kay (White Sox) - 3-1, 4.27 ERA

This contest's pitching matchup is set, as the Twins will send Zebby Matthews (1-1) to the mound, while Anthony Kay (3-1) will get the nod for the White Sox. Matthews has a record of 1-1-0 ATS in two starts with a spread this season. Matthews' team is 1-1 this season when he starts and they're favored on the moneyline. The White Sox have gone 5-2-0 against the spread when Kay starts. The White Sox are 4-3 in Kay's seven starts this season that they were the underdog on the moneyline.

Twins vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (56.9%)

Twins vs White Sox Moneyline

• Looking at the moneyline for White Sox-Twins, Chicago is the underdog at -104, and Minnesota is -112 playing on the road.

Twins vs White Sox Spread

• The White Sox are +1.5 on the spread (-178 to cover), and Minnesota is +146 to cover the runline.

Twins vs White Sox Over/Under

• Twins versus White Sox on May 25 has an over/under of 8.5 runs, with the odds on the over +100 and the under set at -122.

Bet on Minnesota Twins vs. Chicago White Sox on FanDuel today!

Twins vs White Sox Betting Trends

• The Twins have been favorites in 17 games this season and have come away with the win eight times (47.1%) in those contests.
• This season Minnesota has been victorious four times in 11 chances when named as a favorite of at least -112 on the moneyline.
• The Twins and their opponents have gone over the total this season in 31 of their 52 opportunities.
• The Twins are 29-23-0 against the spread in their 52 games that had a posted line this season.
• The White Sox are 21-23 in games they were the underdog on the moneyline (winning 47.7% of those games).
• Chicago has a 20-22 record (winning 47.6% of its games) when playing as a moneyline underdog of -104 or longer.
• The White Sox have played in 50 games with a set over/under, and have combined with opponents to go over the total 29 times (29-21-0).
• The White Sox have covered 58% of their games this season, going 29-21-0 against the spread.

Twins Player Leaders

• Byron Buxton leads Minnesota with 49 hits and a team-best slugging percentage of .578. He's batting .262 with an on-base percentage of .319.
• Among the qualifying hitters in the majors, his batting average ranks 64th, his on-base percentage ranks 99th, and he is sixth in slugging.
• Buxton has recorded at least one hit in two games in a row. In his last five games he is hitting .318 with two doubles, three home runs, a walk and five RBIs.
• Brooks Lee has eight doubles, a triple, five home runs and 13 walks. He's batting .254 and slugging .395 with an on-base percentage of .309.
• Among qualifying hitters, he ranks 77th in batting average, 120th in on-base percentage and 93rd in slugging percentage.
• Lee enters this matchup looking to extend his two-game hit streak. In his last five games he is batting .316 with two doubles, a triple, two walks and two RBIs.
• Austin Martin leads Minnesota with an OBP of .406 this season while batting .297 with 23 walks and 18 runs scored.
• Martin heads into this matchup with three games in a row with at least one hit. In his last five games he is hitting .217 with two doubles, a home run and four RBIs.
• Josh Bell has five home runs, 30 RBI and a batting average of .228 this season.

White Sox Player Leaders

• Miguel Vargas has put up a team-high .376 on-base percentage. He's batting .244 and slugging .500.
• Including all qualified players in the majors, he is 98th in batting average, 25th in on-base percentage and 23rd in slugging percentage.
• Vargas hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .286 with a double, a home run, four walks and two RBIs.
• Munetaka Murakami's 43 hits and .376 on-base percentage both pace his team. He has a batting average of .235 while slugging .530.
• He is currently 110th in batting average, 25th in on-base percentage and 15th in slugging percentage among all qualified hitters.
• Colson Montgomery is batting .219 with eight doubles, 13 home runs and 20 walks.
• Chase Meidroth paces his team with a .375 slugging percentage.

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