Brewers vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 8:12 p.m.

The MLB's Monday slate includes the Milwaukee Brewers facing the St. Louis Cardinals.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Brewers vs Cardinals Game Info

• Milwaukee Brewers (30-20) vs. St. Louis Cardinals (29-22)
• Date: Monday, May 25, 2026
• Time: 2:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: Brewers.TV and Cardinals.TV

Brewers vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-220) | STL: (+184)
• Spread: MIL: -1.5 (+104) | STL: +1.5 (-125)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Brewers vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 4-2, 1.89 ERA vs Michael McGreevy (Cardinals) - 3-3, 2.40 ERA

The Brewers will call on Jacob Misiorowski (4-2) against the Cardinals and Michael McGreevy (3-3). When Misiorowski starts, his team is 6-4-0 against the spread this season. Misiorowski's team is 4-3 this season when he starts and they are the moneyline favorite. The Cardinals have a 7-3-0 ATS record in McGreevy's 10 starts that had a set spread. The Cardinals have a 5-3 record in McGreevy's eight starts this season when they were the underdog on the moneyline.

Brewers vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (60.4%)

Brewers vs Cardinals Moneyline

• Looking at the moneyline for Brewers-Cardinals, Milwaukee is the favorite at -220, and St. Louis is +184 playing on the road.

Brewers vs Cardinals Spread

• The Brewers are hosting the Cardinals and are favored by 1.5 runs (+104 to cover) on the runline. St. Louis is -125 to cover.

Brewers vs Cardinals Over/Under

• The Brewers-Cardinals game on May 25 has been given an over/under of 7.5 runs. The over is set at -115 and the under at -105.

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Brewers vs Cardinals Betting Trends

• The Brewers have won in 18, or 62.1%, of the 29 contests they have been named as odds-on favorites in this year.
• Oddsmakers have given Milwaukee the best odds of winning it has seen this season, with a -220 moneyline listed for this contest.
• Contests with the Brewers have gone over the total set by bookmakers in 22 of 50 chances this season.
• The Brewers have posted a record of 30-20-0 against the spread this season.
• The Cardinals have won 24 of the 41 games they were the moneyline underdog this season (58.5%).
• St. Louis has played as a moneyline underdog of +184 or longer in just one game this season, which it won.
• The Cardinals have combined with opponents to hit the over on the total 22 times this season for a 22-24-4 record against the over/under.
• The Cardinals have covered 60% of their games this season, going 30-20-0 ATS.

Brewers Player Leaders

• Brice Turang has 51 hits and an OBP of .413, both of which are tops among Milwaukee hitters this season. He has a .291 batting average and a slugging percentage of .486.
• Among qualified batters in the majors, his batting average ranks 27th, his on-base percentage ranks third, and he is 32nd in slugging.
• Turang has recorded a base hit in five games in a row. In his last five games he is batting .389 with a double, a home run, four walks and three RBIs.
• William Contreras has hit four homers this season while driving in 30 runs. He's batting .298 this season and slugging .404 with an on-base percentage of .367.
• Among all qualified, he is 16th in batting average, 32nd in on-base percentage and 87th in slugging percentage.
• Contreras heads into this matchup looking to extend his eight-game hit streak. In his last 10 outings he is hitting .333 with a home run, three walks and four RBIs.
• Jake Bauers has 45 hits this season and has a slash line of .285/.354/.481.
• Sal Frelick has three home runs, 18 RBI and a batting average of .217 this season.

Cardinals Player Leaders

• Jordan Walker has a slugging percentage of .594 and has 58 hits, both team-high figures for the Cardinals. He's batting .302 and with an on-base percentage of .372.
• He is 12th in batting average, 29th in on-base percentage and fourth in slugging percentage among all qualified hitters in MLB.
• Walker hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .316 with a double, two home runs, a walk and eight RBIs.
• Alec Burleson is hitting .294 with 13 doubles, seven home runs and 21 walks. He's slugging .469 with an on-base percentage of .365.
• Including all qualified hitters, his batting average puts him 21st, his on-base percentage ranks 35th, and he is 42nd in slugging.
• Ivan Herrera a has .393 on-base percentage to lead the Cardinals.
• JJ Wetherholt is batting .237 with five doubles, nine home runs and 27 walks.

Brewers vs Cardinals Head to Head

• 5/6/2026: 6-2 MIL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/4/2026: 6-3 STL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/21/2025: 5-1 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/20/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/19/2025: 7-1 STL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/14/2025: 3-2 STL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/13/2025: 9-8 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2025: 8-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/15/2025: 3-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/14/2025: 8-5 STL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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