Tigers vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 1:12 p.m.

Sunday's slate in the MLB includes a matchup between the Detroit Tigers and the Boston Red Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Tigers vs Red Sox Game Info

• Detroit Tigers (87-74) vs. Boston Red Sox (88-73)
• Date: Sunday, September 28, 2025
• Time: 3:05 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and FDSDET

Tigers vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-118) | BOS: (-100)
• Spread: DET: -1.5 (+138) | BOS: +1.5 (-166)
• Total: 9 -- Over: (-118) | Under: (-104)

Tigers vs Red Sox Probable Starting Pitchers

Probable Pitchers: Chris Paddack (Tigers) - 5-11, 5.27 ERA vs José De León (Red Sox) - 0-0, 0.00 ERA

The Tigers will give the ball to Chris Paddack (5-11, 5.27 ERA), who is eyeing win No. 6 on the season, and the Red Sox will counter with Jose De Leon. Paddack and his team have a record of 12-14-0 against the spread when he starts. Paddack's team is 4-10 this season when he starts and they are the moneyline favorite. De Leon did not pitch as a moneyline underdog a season ago.

Tigers vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (53.1%)

Tigers vs Red Sox Moneyline

• Detroit is a -118 favorite on the moneyline, while Boston is a -100 underdog at home.

Tigers vs Red Sox Spread

• The Tigers are at the Red Sox and are favored by 1.5 runs on the spread. The Tigers are +138 to cover the runline, with the Red Sox being -166.

Tigers vs Red Sox Over/Under

• An over/under of 9 has been set for Tigers-Red Sox on Sept. 28, with the over being -118 and the under -104.

Bet on Detroit Tigers vs. Boston Red Sox on FanDuel today!

Tigers vs Red Sox Betting Trends

• The Tigers have been victorious in 58, or 55.8%, of the 104 contests they have been chosen as favorites in this season.
• Detroit has a record of 54-43 in contests when bookmakers favor them by -118 or more on the moneyline.
• The Tigers and their opponents have hit the over in 78 of their 154 games with a total set by oddsmakers this season.
• The Tigers are 71-83-0 against the spread in their 154 games that had a posted line this season.
• The Red Sox have won 46.2% of the games this season they were the underdog on the moneyline (24-28).
• Boston has a 21-22 record (winning 48.8% of its games) when it has played as a moneyline underdog of -100 or longer.
• The Red Sox have played in 160 games with an over/under set, and have combined with their opponents to go over the total 74 times (74-79-7).
• The Red Sox have put together an 86-74-0 record against the spread this season (covering 53.8% of the time).

Tigers Player Leaders

• Gleyber Torres leads Detroit with an OBP of .358 this season while batting .256 with 85 walks and 79 runs scored. He has a slugging percentage of .387.
• He ranks 80th in batting average, 21st in on-base percentage, and 120th in slugging among all qualifying batters in baseball.
• Riley Greene leads Detroit with 155 hits and a team-best slugging percentage of .493. He's batting .258 with an on-base percentage of .313.
• He is 71st in batting average, 105th in on-base percentage and 20th in slugging among qualified hitters.
• Spencer Torkelson has collected 135 base hits, an OBP of .333 and a slugging percentage of .456 this season.
• Zach McKinstry has 12 home runs, 49 RBI and a batting average of .261 this season.
• McKinstry enters this matchup on a five-game hitting streak. During his last five outings he is batting .429 with two doubles, a home run, a walk and an RBI.

Red Sox Player Leaders

• Jarren Duran has racked up an on-base percentage of .333 and has 158 hits, both team-best numbers for the Red Sox. He's batting .257 and slugging .442.
• Including all qualifying hitters, he ranks 74th in batting average, while his on-base percentage is 63rd and he is 63rd in slugging.
• Trevor Story's .436 slugging percentage paces his team. He has a batting average of .265 with an on-base percentage of .310.
• He is currently 47th in batting average, 110th in on-base percentage and 69th in slugging percentage among all qualified hitters.
• Alex Bregman has 28 doubles, 18 home runs and 51 walks while hitting .273.
• Ceddanne Rafaela is hitting .247 with 33 doubles, four triples, 16 home runs and 27 walks.

Tigers vs Red Sox Head to Head

• 9/27/2025: 2-1 DET (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/26/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/14/2025: 6-5 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 5/13/2025: 10-9 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/12/2025: 14-2 DET (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/1/2024: 4-1 DET (Favorite: Tigers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/31/2024: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/30/2024: 7-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/2/2024: 8-4 DET (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/1/2024: 6-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!