Tigers vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 1:11 a.m.

MLB action on Tuesday includes the Detroit Tigers playing the Washington Nationals.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Tigers vs Nationals Game Info

• Detroit Tigers (74-83) vs. Washington Nationals (73-84)
• Date: Tuesday, September 22, 2026
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: DSN and Nationals.TV

Tigers vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-158) | WSH: (+134)
• Spread: DET: -1.5 (+146) | WSH: +1.5 (-176)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Tigers vs Nationals Probable Starting Pitchers

Probable Pitchers: Drew Anderson (Tigers) - 5-6, 3.62 ERA vs Jackson Kent (Nationals) - 1-4, 6.40 ERA

The probable starters are Drew Anderson (5-6) for the Tigers and Jackson Kent (1-4) for the Nationals. Anderson and his team have a record of 6-4-0 against the spread when he starts. Anderson's team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 1-2. The Nationals have a 2-5-0 record against the spread in Kent's starts. The Nationals are 2-5 in Kent's seven starts this season that they were the moneyline underdog.

Tigers vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (57.5%)

Tigers vs Nationals Moneyline

• Washington is a +134 underdog on the moneyline, while Detroit is a -158 favorite at home.

Tigers vs Nationals Spread

• The Nationals are +1.5 on the run line against the Tigers. The Nationals are -176 to cover, and the Tigers are +146.

Tigers vs Nationals Over/Under

• A combined run total of 8.5 has been set for Tigers-Nationals on Sept. 22, with the over at +100 and the under at -122.

Bet on Detroit Tigers vs. Washington Nationals on FanDuel today!

Tigers vs Nationals Betting Trends

• The Tigers have won in 43, or 55.1%, of the 78 contests they have been named as odds-on favorites in this year.
• This season Detroit has been victorious 13 times in 18 chances when named as a favorite of at least -158 on the moneyline.
• The Tigers and their opponents have gone over in 67 of their 151 games with a total set by sportsbooks this season.
• The Tigers are 78-73-0 against the spread in their 151 games with a line set by sportsbooks this season.
• The Nationals have won 49 of the 117 games they were the underdog on the moneyline this season (41.9%).
• Washington has a 15-34 record (winning just 30.6% of its games) when playing as a moneyline underdog of +134 or longer.
• The Nationals have combined with opponents to hit the over on the total 81 times this season for an 81-66-6 record against the over/under.
• The Nationals have an 83-70-0 record ATS this season (covering 54.2% of the time).

Tigers Player Leaders

• Kevin McGonigle leads Detroit OPS (.799) this season. He has a .274 batting average, an on-base percentage of .376, and a slugging percentage of .424.
• Among qualifying hitters, he ranks 35th in batting average, his on-base percentage ranks 11th, and he is 68th in slugging.
• Riley Greene leads Detroit with 141 hits. He is batting .284 this season and has 54 extra-base hits. He's also slugging .481 with an on-base percentage of .371.
• Among qualifying hitters, his batting average places him 17th, his on-base percentage 13th, and his slugging percentage 25th.
• Dillon Dingler has collected 132 base hits, an OBP of .304 and a slugging percentage of .453 this season.
• Dingler enters this game with four games in a row with at least one hit. During his last five outings he is batting .278 with two doubles, a walk and an RBI.
• Spencer Torkelson has been key for Detroit with 118 hits, an OBP of .325 plus a slugging percentage of .428.
• Torkelson has safely hit in two straight games. During his last five outings he is batting .333 with a double, a home run, three walks and two RBIs.

Nationals Player Leaders

• C.J. Abrams has accumulated a slugging percentage of .489, a team-high for the Nationals. He's batting .260 with an on-base percentage of .334.
• Including all qualifying hitters in the majors, he is 63rd in batting average, 63rd in on-base percentage and 20th in slugging percentage.
• James Wood's 131 hits and .389 OBP both pace his team. He has a batting average of .265 while slugging .511.
• He ranks 51st in batting average, fourth in on-base percentage and 12th in slugging percentage in the majors.
• Daylen Lile has a .437 slugging percentage, which leads the Nationals.
• Jacob Young has 22 doubles, three triples, 10 home runs and 33 walks while hitting .252.

Tigers vs Nationals Head to Head

• 9/21/2026: 9-2 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/3/2025: 11-7 WSH (Favorite: Tigers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/2/2025: 9-4 WSH (Favorite: Nationals, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/2/2025: 11-2 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 6/13/2024: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/12/2024: 7-5 WSH (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/11/2024: 5-4 WSH (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/21/2023: 6-4 WSH (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/20/2023: 5-2 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/19/2023: 8-6 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

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