Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 1:11 a.m.

MLB action on Tuesday includes the Pittsburgh Pirates facing the St. Louis Cardinals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (79-77) vs. St. Louis Cardinals (76-80)
• Date: Tuesday, September 22, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Cardinals.TV

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-148) | STL: (+126)
• Spread: PIT: -1.5 (+158) | STL: +1.5 (-192)
• Total: 7.5 -- Over: (+104) | Under: (-128)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Jared Jones (Pirates) - 4-6, 4.17 ERA vs Andre Pallante (Cardinals) - 12-7, 3.70 ERA

The Pirates will look to Jared Jones (4-6) against the Cardinals and Andre Pallante (12-7). Jones' team is 9-10-0 against the spread this season in his starts. Jones' team is 3-4 this season when he starts and they are the moneyline favorite. The Cardinals are 14-12-0 ATS in Pallante's 26 starts with a set spread. The Cardinals are 9-4 in Pallante's 13 starts this season that they were the underdog on the moneyline.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (59.2%)

Pirates vs Cardinals Moneyline

• The Pirates vs Cardinals moneyline has Pittsburgh as a -148 favorite, while St. Louis is a +126 underdog on the road.

Pirates vs Cardinals Spread

• The Pirates are hosting the Cardinals and are favored by 1.5 runs (+158 to cover) on the runline. St. Louis is -192 to cover.

Pirates vs Cardinals Over/Under

• The over/under for Pirates-Cardinals on Sept. 22 is 7.5. The over is +104, and the under is -128.

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Pirates vs Cardinals Betting Trends

• The Pirates have come away with 46 wins in the 79 contests they have been listed as the favorites in this season.
• Pittsburgh has a record of 15-13 when favored by -148 or more this year.
• The Pirates and their opponents have gone over in 81 of their 154 games with a total set by sportsbooks this season.
• In 154 games with a line this season, the Pirates have a mark of 77-77-0 against the spread.
• The Cardinals have gone 45-52 in games they were listed as the moneyline underdog (winning 46.4% of those games).
• When it has played as a moneyline underdog with odds of +126 or longer, St. Louis has a 15-16 record (winning 48.4% of its games).
• The Cardinals have played in 152 games with an over/under set, and have combined with opponents to go over the total 71 times (71-74-7).
• The Cardinals have collected an 81-71-0 record against the spread this season.

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh with an OBP of .365 this season while batting .262 with 85 walks and 101 runs scored. He has a slugging percentage of .423.
• Among all qualifying hitters in baseball, he ranks 58th in batting average, 20th in on-base percentage, and 71st in slugging.
• Brandon Lowe has 148 hits, which is best among Pittsburgh batters this season. He's batting .262 with 63 extra-base hits. He's also slugging .492 with an on-base percentage of .332.
• He is 58th in batting average, 67th in on-base percentage and 17th in slugging in the majors.
• Lowe has picked up a hit in eight games in a row. In his last 10 games he is hitting .324 with a double, four home runs, five walks and 10 RBIs.
• Nick Gonzales leads the Pirates with an OPS of .754. He has a slash line of .302/.365/.389 this season.
• Ryan O'Hearn has 18 home runs, 73 RBI and a batting average of .264 this season.

Cardinals Player Leaders

• Alec Burleson has a .466 slugging percentage, which leads the Cardinals. He's batting .282 with an on-base percentage of .347.
• Including all qualified hitters in the majors, his batting average places him 18th, his on-base percentage is 47th, and he is 34th in slugging.
• Jordan Walker has racked up 161 hits to lead his team. He has a batting average of .274 while slugging .474 with an on-base percentage of .332.
• His batting average ranks 35th among all qualified players, his on-base percentage ranks 67th, and he is 29th in slugging.
• Ivan Herrera a has .358 on-base percentage to lead the Cardinals.
• JJ Wetherholt is hitting .242 with 14 doubles, 17 home runs and 63 walks.

Pirates vs Cardinals Head to Head

• 8/30/2026: 5-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/29/2026: 6-2 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/28/2026: 4-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: +104)
• 5/21/2026: 6-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/20/2026: 7-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/19/2026: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2026: 10-5 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/29/2026: 5-4 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/28/2026: 11-7 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/27/2026: 4-2 STL (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)

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