Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 2:13 a.m.

The Detroit Tigers versus the Cleveland Guardians is on the MLB schedule for Wednesday.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Tigers vs Guardians Game Info

• Detroit Tigers (85-66) vs. Cleveland Guardians (79-71)
• Date: Wednesday, September 17, 2025
• Time: 6:40 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: Fox Sports 1, FDSDET, and CLEG

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-154) | CLE: (+130)
• Spread: DET: -1.5 (+142) | CLE: +1.5 (-172)
• Total: 8 -- Over: (-110) | Under: (-110)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Jack Flaherty (Tigers) - 8-13, 4.69 ERA vs Gavin Williams (Guardians) - 10-5, 3.16 ERA

This contest's pitching matchup is set, as the Tigers will send Jack Flaherty (8-13) to the mound, while Gavin Williams (10-5) will get the nod for the Guardians. Flaherty's team is 10-18-0 against the spread this season in his starts. Flaherty's team has been victorious in 38.9% of the games he's started as the moneyline favorite with a record of 7-11. The Guardians are 13-16-0 against the spread when Williams starts. The Guardians are 8-10 in Williams' 18 starts this season that they were the underdog on the moneyline.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (68.4%)

Tigers vs Guardians Moneyline

• The moneyline numbers for Tigers vs. Guardians reveal Detroit as the favorite (-154) and Cleveland as the underdog (+130) on the road.

Tigers vs Guardians Spread

• The Tigers are favored by 1.5 runs at home against the Guardians. The Tigers are +142 to cover the spread, while the Guardians are -172.

Tigers vs Guardians Over/Under

• A combined run total of 8 has been set for Tigers-Guardians on Sept. 17, with the over at -110 and the under at -110.

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Tigers vs Guardians Betting Trends

• The Tigers have been chosen as favorites in 98 games this year and have walked away with the win 58 times (59.2%) in those games.
• This year Detroit has won 34 of 51 games when listed as at least -154 on the moneyline.
• The Tigers and their opponents have gone over in 75 of their 145 games with a total set by sportsbooks this season.
• In 145 games with a line this season, the Tigers have a mark of 69-76-0 against the spread.
• The Guardians have compiled a 37-46 record in games they were the underdog on the moneyline (winning 44.6% of those games).
• When it has played as a moneyline underdog with odds of +130 or longer, Cleveland has a 12-16 record (winning 42.9% of its games).
• In the 147 games bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 64 times (64-77-6).
• The Guardians have a 79-68-0 record ATS this season.

Tigers Player Leaders

• Gleyber Torres leads Detroit with an OBP of .361 this season while batting .254 with 82 walks and 77 runs scored. He has a slugging percentage of .394.
• Among qualified hitters in the majors, his batting average ranks 84th, his on-base percentage ranks 17th, and he is 113th in slugging.
• Riley Greene has 149 hits to go with a slugging percentage of .504, both of which are tops among Detroit hitters this season. He's batting .265 with an on-base percentage of .319.
• He ranks 47th in batting average, 96th in on-base percentage and 14th in slugging in MLB.
• Spencer Torkelson is batting .242 with a .461 slugging percentage and 74 RBI this year.
• Torkelson brings a three-game hitting streak into this game. During his last five outings he is batting .368 with a home run, three walks and two RBIs.
• Zach McKinstry is batting .261 with a .336 OBP and 48 RBI for Detroit this season.

Guardians Player Leaders

• Jose Ramirez has 155 hits with a .355 on-base percentage, leading the Guardians in both statistics. He's batting .282 and slugging .500.
• He ranks 21st in batting average, 29th in on-base percentage and 18th in slugging percentage among all qualifying hitters in the majors.
• Steven Kwan is slugging .377 to lead his team. He has a batting average of .274 with an on-base percentage of .334.
• He ranks 34th in batting average, 63rd in on-base percentage and 128th in slugging percentage in the big leagues.
• Kyle Manzardo has 16 doubles, two triples, 26 home runs and 46 walks while batting .241.
• Angel Martinez is hitting .228 with 22 doubles, two triples, 11 home runs and 19 walks.

Tigers vs Guardians Head to Head

• 9/16/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/6/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/5/2025: 1-0 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/25/2025: 5-0 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/24/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/22/2025: 7-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/12/2024: 7-3 CLE (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/10/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)

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