SMU vs Louisville Basketball Prediction, Odds, Picks, Best Bets for January 21

The SMU Mustangs (14-4, 5-2 ACC) take a three-game winning streak into a home matchup with the Louisville Cardinals (14-5, 7-1 ACC), who have won eight straight.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

SMU vs. Louisville Game Info and Odds

• Game day: Tuesday, January 21, 2025
• Game time: 9:00 PM ET
• TV channel: ACC Network
• Location: Dallas, Texas
• Arena: Moody Coliseum

SMU vs. Louisville Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: SMU win (69.1%)

Before making a wager on Tuesday's SMU-Louisville spread (SMU -1.5) or total (158.5 points), read the betting insights and trends below.

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SMU vs. Louisville: ATS Betting Stats and Trends

• SMU has covered nine times in 18 chances against the spread this season.
• Louisville has compiled an 11-8-0 ATS record so far this year.
• SMU covers the spread when it is a 1.5-point favorite or more 60% of the time. That's less often than Louisville covers as an underdog of 1.5 or more (80%).
• At home, the Mustangs have a better record against the spread (5-5-0) compared to their ATS record in away games (2-3-0).
• This season, the Cardinals are 4-7-0 at home against the spread (.364 winning percentage). On the road, they are 5-0-0 ATS (1.000).
• Against the spread, in conference action, SMU is 4-3-0 this year.
• Louisville is 6-2-0 against the spread in ACC games this season.

SMU vs. Louisville: Moneyline Betting Stats

• SMU has won in 13, or 92.9%, of the 14 contests it has been named as the moneyline favorite in this year.
• The Mustangs have been a -132 moneyline favorite on 13 occasions this season and won every game.
• Louisville has put together a 2-2 record in games it was listed as the moneyline underdog (winning 50% of those games).
• When they have played as a moneyline underdog with odds of +110 or longer, the Cardinals have a 2-2 record (winning 50% of their games).
• The moneyline set for this matchup implies SMU has a 56.9% chance of coming away with a victory in the contest.

SMU vs. Louisville Head-to-Head Comparison

• SMU outscores opponents by 13.2 points per game (scoring 84.8 per game to rank 15th in college basketball while allowing 71.6 per contest to rank 191st in college basketball) and has a +238 scoring differential overall.
• Kevin Miller's team-leading 14.7 points per game ranks 286th in the country.
• Louisville outscores opponents by 8.8 points per game (posting 78.4 points per game, 92nd in college basketball, and allowing 69.6 per outing, 116th in college basketball) and has a +167 scoring differential.
• Chucky Hepburn leads Louisville, scoring 15.2 points per game (237th in college basketball).
• The Mustangs grab 35.9 rebounds per game (39th in college basketball) while conceding 28.1 per contest to their opponents. They outrebound opponents by 7.8 boards per game.
• Matt Cross averages eight rebounds per game (ranking 77th in college basketball) to lead the Mustangs.
• The Cardinals rank 32nd in the nation at 36.1 rebounds per game. That's 6.3 more than the 29.8 their opponents average.
• J'Vonne Hadley's 7.6 rebounds per game lead the Cardinals and rank 107th in the nation.
• SMU ranks 27th in college basketball with 104.6 points scored per 100 possessions, and 100th in college basketball defensively with 88.3 points conceded per 100 possessions.
• The Cardinals average 99.8 points per 100 possessions on offense (95th in college basketball), and allow 88.6 points per 100 possessions (107th in college basketball).

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