Duke vs Illinois Basketball Prediction, Odds, Picks, Best Bets for February 22

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The Duke Blue Devils (23-3) hope to continue a 13-game home win streak when they host the Illinois Fighting Illini (17-10) on February 22, 2025.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Illinois Game Info and Odds

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (74.7%)

Before you wager on Saturday's Duke-Illinois spread (Duke -9.5) or total (156.5 points), see the betting insights and trends below.

Duke has compiled a 16-10-0 ATS record so far this year.
Illinois has won 13 games against the spread this season, while failing to cover 14 times.
The Blue Devils have done a better job covering the spread on the road (7-2-0) than they have at home (9-6-0).
This year, the Fighting Illini are 8-7-0 at home against the spread (.533 winning percentage). Away, they are 4-5-0 ATS (.444).

Duke has come away with 21 wins in the 24 contests it has been listed as the moneyline favorite in this season.
The Blue Devils have not lost in 18 games this year when favored by -450 or better on the moneyline.
Illinois is 1-4 in games it was listed as the moneyline underdog (winning 20% of those games).
The Fighting Illini have yet to play a game with moneyline odds of +340 or longer.
Oddsmakers have implied with the moneyline set for this matchup that Duke has a 81.8% chance of pulling out a win.

Duke outscores opponents by 20.2 points per game (scoring 81 per game to rank 36th in college basketball while allowing 60.8 per outing to rank sixth in college basketball) and has a +524 scoring differential overall.
Duke's leading scorer, Cooper Flagg, is 20th in the country averaging 19.7 points per game.
Illinois outscores opponents by 11.5 points per game (posting 83.9 points per game, ninth in college basketball, and giving up 72.4 per outing, 200th in college basketball) and has a +310 scoring differential.
Kasparas Jakucionis leads Illinois, scoring 15.6 points per game (214th in college basketball).
The Blue Devils rank 25th in the nation at 35.8 rebounds per game. That's 9.1 more than the 26.7 their opponents average.
Flagg is 88th in college basketball play with 7.7 rebounds per game to lead the Blue Devils.
The Fighting Illini rank first in the nation at 40.9 rebounds per game. That's 10.7 more than the 30.2 their opponents average.
Tomislav Ivisic's 8.3 rebounds per game lead the Fighting Illini and rank 51st in the country.
Duke ranks second in college basketball by averaging 109.4 points per 100 possessions on offense, and defensively is seventh in college basketball, allowing 82.2 points per 100 possessions.
The Fighting Illini rank 63rd in college basketball with 100.9 points scored per 100 possessions, and 46th defensively with 87.1 points conceded per 100 possessions.

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