Reds vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 1:11 a.m.

The Cincinnati Reds are among the MLB squads busy on Wednesday, versus the Pittsburgh Pirates.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Reds vs Pirates Game Info

• Cincinnati Reds (25-25) vs. Pittsburgh Pirates (16-33)
• Date: Wednesday, May 21, 2025
• Time: 12:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and FDSOH

Reds vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-126) | PIT: (+108)
• Spread: CIN: -1.5 (+130) | PIT: +1.5 (-156)
• Total: 8 -- Over: (-115) | Under: (-105)

Reds vs Pirates Probable Starting Pitchers

Probable Pitchers: Brady Singer (Reds) - 5-2, 5.01 ERA vs Andrew Heaney (Pirates) - 2-3, 3.02 ERA

The probable starters are Brady Singer (5-2) for the Reds and Andrew Heaney (2-3) for the Pirates. When Singer starts, his team is 6-3-0 against the spread this season. When Singer starts a game and his team is the favorite on the moneyline, they have a record of 2-2. The Pirates have a 3-5-0 record against the spread in Heaney's starts. The Pirates have been the moneyline underdog in six of Heaney's starts this season, and they went 2-4 in those matchups.

Reds vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (54.6%)

Reds vs Pirates Moneyline

• Looking at the moneyline for Reds-Pirates, Cincinnati is the favorite at -126, and Pittsburgh is +108 playing at home.

Reds vs Pirates Spread

• The Reds are at the Pirates and are favored by 1.5 runs (+130 to cover) on the runline. Pittsburgh is -156 to cover.

Reds vs Pirates Over/Under

• The over/under for the Reds versus Pirates contest on May 21 has been set at 8, with -115 odds on the over and -105 odds on the under.

Bet on Cincinnati Reds vs. Pittsburgh Pirates on FanDuel today!

Reds vs Pirates Betting Trends

• The Reds have won in 12, or 57.1%, of the 21 contests they have been named as odds-on favorites in this year.
• Cincinnati has a record of 7-6 when favored by -126 or more this year.
• The Reds and their opponents have gone over the total this season in 18 of their 48 opportunities.
• The Reds have posted a record of 26-22-0 against the spread this season.
• The Pirates have won 11 of the 32 games they were listed as the moneyline underdog this season (34.4%).
• Pittsburgh has gone 9-18 when it has played as a moneyline underdog with odds of +108 or longer (33.3%).
• The Pirates have combined with opponents to hit the over on the total 17 times this season for a 17-27-3 record against the over/under.
• The Pirates have covered 40.4% of their games this season, going 19-28-0 ATS.

Reds Player Leaders

• Elly De La Cruz is batting .246 with eight doubles, eight home runs and 19 walks. He has an on-base percentage of .318 and a slugging percentage of .410.
• Among qualifying hitters in MLB, his batting average ranks 97th, his on-base percentage ranks 98th, and he is 88th in slugging.
• TJ Friedl has an OPS of .766, fueled by an OBP of .366 and a team-best slugging percentage of .400 this season. He's batting .280.
• Among qualified hitters, his batting average ranks him 48th, his on-base percentage 40th, and his slugging percentage 97th.
• Friedl has picked up at least one hit in two straight games. In his last five games he is hitting .333 with two doubles, a triple, three walks and an RBI.
• Gavin Lux leads Cincinnati with 45 hits and an OBP of .379 this season.
• Austin Hays has been key for Cincinnati with 29 hits, an OBP of .364 plus a slugging percentage of .582.

Pirates Player Leaders

• Oneil Cruz has 31 hits, a team-high for the Pirates. He's batting .220 and slugging .426 with an on-base percentage of .353.
• Including all qualified hitters in the big leagues, he is 136th in batting average, 54th in on-base percentage and 75th in slugging percentage.
• Andrew McCutchen has seven doubles, three home runs and 20 walks while batting .243. He's slugging .357 with an on-base percentage of .344.
• His batting average is 100th among all qualified players, his on-base percentage is 64th, and he is 133rd in slugging.
• Bryan Reynolds has five doubles, six home runs and 17 walks while hitting .206.
• Isiah Kiner-Falefa is hitting .282 with three doubles, a triple, a home run and eight walks.

Reds vs Pirates Head to Head

• 5/20/2025: 1-0 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/19/2025: 7-1 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/12/2025: 5-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/11/2025: 5-3 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 9/22/2024: 2-0 PIT (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/21/2024: 7-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/20/2024: 8-3 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/25/2024: 4-3 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/24/2024: 10-2 CIN (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -108, Underdog Moneyline: -108)

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