Mariners vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 2:11 a.m.

The MLB's Wednesday slate includes the Seattle Mariners taking on the Chicago White Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Mariners vs White Sox Game Info

• Seattle Mariners (27-20) vs. Chicago White Sox (15-34)
• Date: Wednesday, May 21, 2025
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and ROOT Sports NW

Mariners vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-180) | CHW: (+152)
• Spread: SEA: -1.5 (-110) | CHW: +1.5 (-110)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Mariners vs White Sox Probable Starting Pitchers

Probable Pitchers: Logan Evans (Mariners) - 2-1, 4.71 ERA vs Shane Smith (White Sox) - 1-3, 2.05 ERA

The Mariners will call on Logan Evans (2-1) versus the White Sox and Shane Smith (1-3). Evans and his team have a record of 1-3-0 against the spread when he starts. Evans' team is 1-1 this season when he starts and they're favored on the moneyline. The White Sox have a 3-6-0 ATS record in Smith's nine starts that had a set spread. The White Sox have been the underdog on the moneyline in eight of Smith's starts this season, and they went 1-7 in those matchups.

Mariners vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (62.4%)

Mariners vs White Sox Moneyline

• The Mariners vs White Sox moneyline has Seattle as a -180 favorite, while Chicago is a +152 underdog at home.

Mariners vs White Sox Spread

• The Mariners are at the White Sox and are favored by 1.5 runs on the spread. The Mariners are -110 to cover the runline, with the White Sox being -110.

Mariners vs White Sox Over/Under

• The over/under for the Mariners versus White Sox game on May 21 has been set at 8.5, with -106 odds on the over and -114 odds on the under.

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Mariners vs White Sox Betting Trends

• The Mariners have been favorites in 27 games this season and have come away with the win 16 times (59.3%) in those contests.
• Seattle has a record of 4-2 in contests when bookmakers favor them by -180 or more on the moneyline.
• The Mariners and their opponents have gone over the total this season in 25 of their 46 opportunities.
• The Mariners have posted a record of 24-22-0 against the spread this season.
• The White Sox have won 13 of the 46 games they were listed as the moneyline underdog this season (28.3%).
• Chicago has a 6-24 record (winning only 20% of its games) when it has played as a moneyline underdog of +152 or longer.
• The White Sox have played in 47 games with a set over/under, and have combined with opponents to go over the total 21 times (21-23-3).
• The White Sox have put together a 23-24-0 record against the spread this season.

Mariners Player Leaders

• Cal Raleigh leads Seattle in total hits (41) this season while batting .241 with 24 extra-base hits. He has an on-base percentage of .360 and a slugging percentage of .559.
• Among all qualified hitters, he is 103rd in batting average, his on-base percentage ranks 44th, and he is 10th in slugging.
• Julio Rodriguez has hit eight homers this season while driving in 25 runs. He's batting .232 this season and slugging .405 with an on-base percentage of .311.
• Among qualifying batters, he is 116th in batting average, 107th in on-base percentage and 91st in slugging percentage.
• Jorge Polanco has collected 37 base hits, an OBP of .351 and a slugging percentage of .603 this season.
• J.P. Crawford leads Seattle with an OBP of .390 this season while batting .274 with 29 walks and 20 runs scored.
• Crawford brings a three-game hitting streak into this game. In his last five games he is hitting .294 with a double, a home run, six walks and an RBI.

White Sox Player Leaders

• Miguel Vargas has accumulated an on-base percentage of .319 and has 40 hits, both team-best numbers for the White Sox. He's batting .240 and slugging .407.
• Including all qualified players in the big leagues, he ranks 106th in batting average, 97th in on-base percentage and 90th in slugging percentage.
• Luis Robert is batting .182 with four doubles, five home runs and 21 walks. He's slugging .302 with an on-base percentage of .276.
• He is 159th in batting average, 140th in on-base percentage and 159th in slugging percentage in the majors.
• Chase Meidroth is batting .295 with three doubles, a home run and 12 walks.
• Lenyn Sosa's .380 slugging percentage paces his team.

Mariners vs White Sox Head to Head

• 5/19/2025: 5-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/28/2024: 6-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/27/2024: 6-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/26/2024: 10-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 6/13/2024: 3-2 CHW (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/12/2024: 2-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 6/11/2024: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/10/2024: 8-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/23/2023: 5-4 CHW (Favorite: Mariners, Spread: -1.5, Total: 9.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 8/22/2023: 6-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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