Red Sox vs Mets Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 5:13 a.m.

The Boston Red Sox are among the MLB teams busy on Wednesday, versus the New York Mets.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Mets Game Info

• Boston Red Sox (25-25) vs. New York Mets (29-20)
• Date: Wednesday, May 21, 2025
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: MLB Network, NESN, and SNY

Red Sox vs Mets Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-144) | NYM: (+122)
• Spread: BOS: -1.5 (+132) | NYM: +1.5 (-160)
• Total: 8 -- Over: (-110) | Under: (-110)

Red Sox vs Mets Probable Starting Pitchers

Probable Pitchers: Garrett Crochet (Red Sox) - 4-3, 2.00 ERA vs Tylor Megill (Mets) - 3-4, 3.74 ERA

The Red Sox will look to Garrett Crochet (4-3) against the Mets and Tylor Megill (3-4). When Crochet starts, his team is 5-5-0 against the spread this season. Crochet's team has a record of 5-4 this season when he starts and they are the favorite on the moneyline. The Mets have gone 2-7-0 ATS in Megill's nine starts with a set spread. The Mets were named the moneyline underdog for two Megill starts this season -- they split the games.

Red Sox vs Mets Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (52.1%)

Red Sox vs Mets Moneyline

• Looking at the moneyline for Mets-Red Sox, New York is the underdog at +122, and Boston is -144 playing at home.

Red Sox vs Mets Spread

• The Mets are at the Red Sox, and are +1.5 on the runline. The Mets are +132 to cover the spread, and the Red Sox are -160.

Red Sox vs Mets Over/Under

• Red Sox versus Mets on May 21 has an over/under of 8 runs, with the odds on the over -110 and the under set at -110.

Bet on Boston Red Sox vs. New York Mets on FanDuel today!

Red Sox vs Mets Betting Trends

• The Red Sox have come away with 18 wins in the 35 contests they have been listed as the favorites in this season.
• This season Boston has been victorious five times in 11 chances when named as a favorite of at least -144 on the moneyline.
• The Red Sox and their opponents have hit the over in 24 of their 50 games with a total set by oddsmakers this season.
• The Red Sox are 26-24-0 against the spread in their 50 games that had a posted line this season.
• The Mets have been the underdog on the moneyline 13 total times this season. They've gone 6-7 in those games.
• New York has played as a moneyline underdog of +122 or longer in just two games this season, which it lost both.
• In the 48 games oddsmakers have set an over/under for the Mets, they have combined with opponents to go over the total 17 times (17-29-2).
• The Mets have collected a 22-26-0 record against the spread this season (covering 45.8% of the time).

Red Sox Player Leaders

• Alex Bregman leads Boston in slugging percentage (.565) and total hits (58) this season. He's batting .304 with an on-base percentage of .388.
• Among all qualifying hitters in the majors, he ranks 17th in batting average, 15th in on-base percentage, and seventh in slugging.
• Bregman hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .188 with two doubles, three walks and two RBIs.
• Rafael Devers leads Boston in OBP (.407) this season, fueled by 53 hits. He's batting .286 while slugging .524.
• Among qualified batters, he ranks 35th in batting average, fifth in on-base percentage and 18th in slugging percentage.
• Wilyer Abreu has collected 43 base hits, an OBP of .351 and a slugging percentage of .515 this season.
• Abreu enters this matchup with two games in a row with at least one hit. In his last five games he is hitting .125 with a double.
• Jarren Duran has been key for Boston with 56 hits, an OBP of .314 plus a slugging percentage of .415.

Mets Player Leaders

• Pete Alonso has an on-base percentage of .400 and has 53 hits, both team-high numbers for the Mets. He's batting .294 and slugging .544.
• He is 25th in batting average, ninth in on-base percentage and 13th in slugging percentage among all qualified hitters in MLB.
• Juan Soto is batting .247 with nine doubles, eight home runs and 38 walks. He's slugging .437 with an on-base percentage of .379.
• Including all qualified players, he ranks 94th in batting average, 24th in on-base percentage and 69th in slugging percentage.
• Francisco Lindor has a .461 slugging percentage, which paces the Mets.
• Brandon Nimmo has nine doubles, eight home runs and 15 walks while hitting .215.

Red Sox vs Mets Head to Head

• 5/20/2025: 2-0 BOS (Favorite: Mets, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/19/2025: 3-1 BOS (Favorite: Mets, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/4/2024: 8-3 NYM (Favorite: Mets, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/3/2024: 7-2 NYM (Favorite: Mets, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/2/2024: 4-1 NYM (Favorite: Mets, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/23/2023: 6-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/22/2023: 8-6 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -122, Underdog Moneyline: +104)

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