Athletics vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 11:12 a.m.

In MLB action on Wednesday, the Athletics take on the Los Angeles Angels.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this matchup.

Athletics vs Angels Game Info

• Athletics (22-27) vs. Los Angeles Angels (22-25)
• Date: Wednesday, May 21, 2025
• Time: 10:05 p.m. ET
• Venue: Sutter Health Park -- West Sacramento, California
• Coverage: NBCS-CA and FDSW

Athletics vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: OAK: (-166) | LAA: (+140)
• Spread: OAK: -1.5 (+106) | LAA: +1.5 (-128)
• Total: 10.5 -- Over: (-118) | Under: (-104)

Athletics vs Angels Probable Starting Pitchers

Probable Pitchers: JP Sears (Athletics) - 4-3, 3.31 ERA vs Jack Kochanowicz (Angels) - 3-5, 4.71 ERA

The Athletics will give the ball to JP Sears (4-3, 3.31 ERA), who is eyeing win No. 5 on the season, and the Angels will counter with Jack Kochanowicz (3-5, 4.71 ERA). Sears and his team have a record of 6-3-0 against the spread when he starts. Sears' team has won each of the three games he's started as the moneyline favorite. The Angels are 3-6-0 against the spread when Kochanowicz starts. The Angels are 3-4 in Kochanowicz's seven starts this season that they were the underdog on the moneyline.

Athletics vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Athletics win (60.1%)

Athletics vs Angels Moneyline

• The Athletics vs Angels moneyline has the Athletics as a -166 favorite, while the Angels are a +140 underdog on the road.

Athletics vs Angels Spread

• The Athletics are 1.5-run favorites on the runline against the Angels. The Athletics are +106 to cover, while the Angels are -128 to cover.

Athletics vs Angels Over/Under

• Athletics versus Angels, on May 21, has an over/under of 10.5, with the over being -118 and the under -104.

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Athletics vs Angels Betting Trends

• The Athletics have been victorious in nine, or 56.2%, of the 16 contests they have been chosen as favorites in this season.
• This season, the Athletics have come away with a win two times in four chances when named as a favorite of at least -166 or better on the moneyline.
• The Athletics and their opponents have hit the over in 26 of their 49 games with a total this season.
• The Athletics are 24-25-0 against the spread in their 49 games that had a posted line this season.
• The Angels have been the moneyline underdog 39 total times this season. They've finished 18-21 in those games.
• The Angels have gone 7-7 when playing as a moneyline underdog with odds of +140 or longer (50%).
• The Angels have combined with their opponents to go over the total 26 times this season for a 26-20-1 record against the over/under.
• The Angels have a 21-26-0 record ATS this season.

Athletics Player Leaders

• Jacob Wilson has an OPS of .859, fueled by an OBP of .381 to go with a slugging percentage of .478. He has a .341 batting average, as well.
• Among qualified hitters in baseball, he ranks third in batting average, 19th in on-base percentage, and 41st in slugging.
• Tyler Soderstrom has 51 hits, which ranks first among Sacramento batters this season. He's batting .270 with 20 extra-base hits. He's also slugging .481 with an on-base percentage of .329.
• He is 61st in batting average, 83rd in on-base percentage and 40th in slugging among qualifying hitters.
• Soderstrom has picked up a hit in two straight games. In his last five games he is hitting .190 with two doubles and an RBI.
• Shea Langeliers has collected 41 base hits, an OBP of .320 and a slugging percentage of .463 this season.
• Langeliers has picked up a hit in two straight games. During his last five outings he is hitting .176 with a home run, two walks and two RBIs.
• Brent Rooker has 10 home runs, 23 RBI and a batting average of .241 this season.
• Rooker heads into this game on a two-game hitting streak. During his last five outings he is hitting .167 with three walks and an RBI.

Angels Player Leaders

• Nolan Schanuel has racked up an on-base percentage of .366 and a slugging percentage of .403. Both lead the Angels. He's batting .277.
• Including all qualifying hitters, he ranks 52nd in batting average, while his on-base percentage is 39th and he is 94th in slugging.
• Schanuel hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .400 with three doubles, a home run, four walks and four RBIs.
• Taylor Ward is hitting .203 with nine doubles, 13 home runs and 12 walks. He's slugging .467 with an on-base percentage of .250.
• He is 152nd in batting average, 160th in on-base percentage and 44th in slugging percentage in MLB.
• Zach Neto has nine doubles, seven home runs and seven walks while batting .278.
• Logan O'Hoppe has racked up 38 hits to pace his team.

Athletics vs Angels Head to Head

• 5/20/2025: 7-5 LAA (Favorite: Athletics, Spread: -1.5, Total: 10.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/19/2025: 4-3 LAA (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/28/2024: 8-6 LAA (Favorite: Angels, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/27/2024: 3-1 OAK (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/26/2024: 5-4 OAK (Favorite: Angels, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/25/2024: 6-5 OAK (Favorite: Athletics, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/21/2024: 8-5 LAA (Favorite: Athletics, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/20/2024: 8-2 OAK (Favorite: Athletics, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/19/2024: 13-3 OAK (Favorite: Athletics, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/4/2024: 5-0 OAK (Favorite: Athletics, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)

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