Dodgers vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 11:12 a.m.

The Los Angeles Dodgers are among the MLB squads in action on Wednesday, versus the Arizona Diamondbacks.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Dodgers vs Diamondbacks Game Info

• Los Angeles Dodgers (30-19) vs. Arizona Diamondbacks (26-23)
• Date: Wednesday, May 21, 2025
• Time: 10:10 p.m. ET
• Venue: Dodger Stadium -- Los Angeles, California
• Coverage: SportsNet LA and ARID

Dodgers vs Diamondbacks Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: LAD: (-138) | ARI: (+118)
• Spread: LAD: -1.5 (+138) | ARI: +1.5 (-166)
• Total: 9 -- Over: (-114) | Under: (-106)

Dodgers vs Diamondbacks Probable Starting Pitchers

Probable Pitchers: Dustin May (Dodgers) - 1-4, 4.43 ERA vs Corbin Burnes (Diamondbacks) - 3-1, 2.56 ERA

The Dodgers will give the nod to Dustin May (1-4, 4.43 ERA), who is eyeing win No. 2 on the season, and the Diamondbacks will counter with Corbin Burnes (3-1, 2.56 ERA). May's team is 2-6-0 against the spread in his starts this season. When May starts a game and his team is the favorite on the moneyline, they have a record of 3-4. The Diamondbacks are 3-5-0 against the spread when Burnes starts. The Diamondbacks have not been a moneyline underdog when Burnes starts this season.

Dodgers vs Diamondbacks Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Dodgers win (53.7%)

Dodgers vs Diamondbacks Moneyline

• The Dodgers vs Diamondbacks moneyline has Los Angeles as a -138 favorite, while Arizona is a +118 underdog on the road.

Dodgers vs Diamondbacks Spread

• The Diamondbacks are +1.5 on the run line against the Dodgers. The Diamondbacks are -166 to cover, and the Dodgers are +138.

Dodgers vs Diamondbacks Over/Under

• Dodgers versus Diamondbacks, on May 21, has an over/under of 9, with the over being -114 and the under -106.

Bet on Los Angeles Dodgers vs. Arizona Diamondbacks on FanDuel today!

Dodgers vs Diamondbacks Betting Trends

• The Dodgers have been chosen as favorites in 43 games this year and have walked away with the win 27 times (62.8%) in those games.
• Los Angeles has a record of 24-12 in contests when sportsbooks favor them by -138 or more on the moneyline.
• The Dodgers and their opponents have gone over in 27 of their 48 games with a total set by sportsbooks this season.
• The Dodgers have an against the spread record of 22-26-0 in 48 games with a line this season.
• The Diamondbacks have won 47.1% of the games this season they were the moneyline underdog (8-9).
• Arizona is 5-3 (winning 62.5% of its games) when playing as a moneyline underdog of +118 or longer.
• In the 48 games oddsmakers have set an over/under for the Diamondbacks, they have combined with opponents to go over the total 22 times (22-23-3).
• The Diamondbacks have covered 47.9% of their games this season, going 23-25-0 ATS.

Dodgers Player Leaders

• Shohei Ohtani leads Los Angeles in slugging percentage (.668) thanks to 30 extra-base hits. He has a .311 batting average and an on-base percentage of .405.
• Among all qualifying batters in baseball, he ranks eighth in batting average, sixth in on-base percentage, and third in slugging.
• Ohtani hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .318 with a double, two home runs, two walks and three RBIs.
• Mookie Betts has five doubles, a triple, eight home runs and 23 walks. He's batting .261 and slugging .438 with an on-base percentage of .347.
• His batting average is 75th among qualified players, his on-base percentage 61st, and his slugging percentage 68th.
• Betts has picked up at least one hit in two straight games. During his last five outings he is batting .200 with two home runs, three walks and two RBIs.
• Freddie Freeman has 52 hits and is batting .371 this season.
• Freeman brings a four-game hitting streak into this matchup. In his last five games he is hitting .381 with three doubles and a walk.
• Teoscar Hernandez is batting .306 with a .329 OBP and 35 RBI for Los Angeles this season.

Diamondbacks Player Leaders

• Corbin Carroll has accumulated 57 hits with a .597 slugging percentage, both team-best numbers for the Diamondbacks. He's batting .277 and with an on-base percentage of .349.
• Including all qualified hitters in the big leagues, he is 52nd in batting average, 60th in on-base percentage and fourth in slugging percentage.
• Geraldo Perdomo's .405 on-base percentage paces his team. He has a batting average of .307 while slugging .494.
• Including all qualified hitters, his batting average puts him 14th, his on-base percentage is sixth, and he is 29th in slugging.
• Josh Naylor is batting .291 with 12 doubles, five home runs and 19 walks.
• Eugenio Suarez has nine doubles, 14 home runs and 17 walks while hitting .213.

Dodgers vs Diamondbacks Head to Head

• 5/20/2025: 4-3 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 5/19/2025: 9-5 ARI (Favorite: Dodgers, Spread: -1.5, Total: 10.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/11/2025: 8-1 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/10/2025: 3-0 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/9/2025: 14-11 LAD (Favorite: Diamondbacks, Spread: -1.5, Total: 10.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/8/2025: 5-3 ARI (Favorite: Dodgers, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/2/2024: 11-6 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/1/2024: 14-3 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2024: 8-6 LAD (Favorite: Dodgers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/30/2024: 10-9 LAD (Favorite: Dodgers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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