Red Sox vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 21

Odds updated as of 12:11 a.m.

The MLB schedule on Monday includes the Boston Red Sox taking on the Chicago White Sox.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Red Sox vs White Sox Game Info

• Boston Red Sox (12-11) vs. Chicago White Sox (5-16)
• Date: Monday, April 21, 2025
• Time: 11:10 a.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and CHSN

Red Sox vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-270) | CHW: (+220)
• Spread: BOS: -1.5 (-137) | CHW: +1.5 (+114)
• Total: 9 -- Over: (-110) | Under: (-110)

Red Sox vs White Sox Probable Starting Pitchers

Probable Pitchers: Walker Anthony Buehler (Red Sox) - 2-1, 5.23 ERA vs Jonathan Cannon (White Sox) - 0-2, 4.42 ERA

The Red Sox will give the ball to Walker Anthony Buehler (2-1, 5.23 ERA), who is eyeing win No. 3 on the season, and the White Sox will counter with Jonathan Cannon (0-2, 4.42 ERA). Buehler's team is 2-2-0 against the spread in his starts this season. Buehler's team is 2-0 this season when he starts and they're favored on the moneyline. The White Sox are 1-3-0 against the spread when Cannon starts. The White Sox were named the moneyline underdog for four Cannon starts this season -- they lost every time.

Red Sox vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (59.8%)

Red Sox vs White Sox Moneyline

• Looking at the moneyline for Red Sox-White Sox, Boston is the favorite at -270, and Chicago is +220 playing on the road.

Red Sox vs White Sox Spread

• The Red Sox are favored by 1.5 runs at home against the White Sox. The Red Sox are -137 to cover the spread, while the White Sox are +114.

Red Sox vs White Sox Over/Under

• Red Sox versus White Sox on April 21 has an over/under of 9 runs, with the odds on the over -110 and the under set at -110.

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Red Sox vs White Sox Betting Trends

• The Red Sox have been chosen as favorites in 16 games this year and have walked away with the win nine times (56.2%) in those games.
• Boston has been listed as a favorite of -270 or more on two occasions this season and split those games.
• The Red Sox and their opponents have gone over the total this season in nine of their 23 opportunities.
• In 23 games with a line this season, the Red Sox have a mark of 11-12-0 against the spread.
• The White Sox have put together a 5-16 record in games they were the underdog on the moneyline (winning 23.8% of those games).
• Chicago has played as a moneyline underdog of +220 or longer in only two games this season, which it split 1-1.
• The White Sox have had an over/under set by bookmakers 21 times, and have combined with opponents to go over the total in nine of those games (9-10-2).
• The White Sox have an 11-10-0 record ATS this season.

Red Sox Player Leaders

• Alexander David Bregman has seven doubles, four home runs and seven walks while hitting .292. He has an on-base percentage of .360 and a slugging percentage of .506.
• He ranks 40th in batting average, 46th in on-base percentage, and 32nd in slugging among all qualified batters in MLB.
• Wilyer Abreu leads the Red Sox in OBP (.405) and total hits (20) this season. He's batting .286 while slugging .529.
• Among qualifying batters, he ranks 48th in batting average, 15th in on-base percentage and 25th in slugging percentage.
• Trevor Story leads Boston in slugging percentage (.518) powered by seven extra-base hits.
• Story has picked up a hit in two games in a row. During his last five outings he is hitting .350 with two home runs, a walk and six RBI.
• Kristian Campbell is batting .301 with a .402 OBP and six RBI for Boston this season.
• Campbell has hit safely in two games in a row. During his last five outings he is batting .278 with a double, a home run, three walks and an RBI.

White Sox Player Leaders

• Luis Robert is hitting .154 with a double, two home runs and 12 walks. He's slugging .262 with an on-base percentage of .282.
• Including all qualified hitters, he is 169th in batting average, while his on-base percentage is 128th and he is 161st in slugging.
• Andrew Sebastian Benintendi is hitting .217 with three home runs and three walks. He's slugging .413 with an on-base percentage of .265.
• Matt Thaiss has two doubles, a home run and nine walks while hitting .229.
• Brooks Baldwin is hitting .255 with a double, two home runs and a walk.

Red Sox vs White Sox Head to Head

• 4/20/2025: 8-4 CHW (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 4/19/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -350, Underdog Moneyline: +280)
• 4/18/2025: 10-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/13/2025: 3-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 4/12/2025: 3-2 CHW (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/11/2025: 11-1 CHW (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/8/2024: 7-2 CHW (Favorite: Red Sox, Spread: -1.5, Total: 10, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 9/7/2024: 7-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/6/2024: 3-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 6/9/2024: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)

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