Red Sox vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 2:11 a.m.

MLB action on Thursday includes the Boston Red Sox facing the Cleveland Guardians.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Red Sox vs Guardians Game Info

• Boston Red Sox (85-73) vs. Cleveland Guardians (82-76)
• Date: Thursday, September 24, 2026
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and CleGuardians.TV

Red Sox vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-134) | CLE: (+116)
• Spread: BOS: -1.5 (+168) | CLE: +1.5 (-205)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Red Sox vs Guardians Probable Starting Pitchers

Probable Pitchers: Ranger Suarez (Red Sox) - 8-4, 3.27 ERA vs Daniel Espino (Guardians) - 0-0, 4.73 ERA

This contest's pitching matchup is set, as the Red Sox will send Ranger Suarez (8-4) to the mound, while Daniel Espino will take the ball for the Guardians. Suarez and his team are 15-12-0 ATS this season when he starts. Suarez's team is 12-8 this season when he starts and they are the moneyline favorite. Espino has started two games with set spreads, and the Guardians went 1-1-0. The Guardians have not been a moneyline underdog when Espino starts this season.

Red Sox vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (59.6%)

Red Sox vs Guardians Moneyline

• Cleveland is a +116 underdog on the moneyline, while Boston is a -134 favorite at home.

Red Sox vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Red Sox. The Guardians are -205 to cover the spread, and the Red Sox are +168.

Red Sox vs Guardians Over/Under

• An over/under of 7.5 has been set for Red Sox-Guardians on Sept. 24, with the over being -110 and the under -110.

Bet on Boston Red Sox vs. Cleveland Guardians on FanDuel today!

Red Sox vs Guardians Betting Trends

• The Red Sox have won in 59, or 54.6%, of the 108 contests they have been named as odds-on favorites in this year.
• Boston has a record of 32-29 in contests when sportsbooks favor them by -134 or more on the moneyline.
• The Red Sox and their opponents have hit the over in 68 of their 155 games with a total set by oddsmakers this season.
• The Red Sox have an against the spread mark of 73-82-0 in 155 games with a line this season.
• The Guardians have won 29 of the 57 games they were listed as the moneyline underdog this season (50.9%).
• Cleveland is 14-11 (winning 56% of its games) when it has played as a moneyline underdog of +116 or longer.
• In the 149 games bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 73 times (73-76-0).
• The Guardians have gone 71-78-0 ATS this season.

Red Sox Player Leaders

• Wilyer Abreu has 37 doubles, four triples, 24 home runs and 70 walks while batting .253. He has an on-base percentage of .332 and a slugging percentage of .454.
• Among all qualifying hitters in MLB, he ranks 76th in batting average, 66th in on-base percentage, and 40th in slugging.
• Abreu has hit safely in two straight games. In his last five games he is hitting .222 with a double and three walks.
• Caleb Durbin is batting .252 with 25 doubles, a triple, 13 home runs and 50 walks. He's slugging .384 with an on-base percentage of .336.
• Among qualifying hitters, his batting average places him 77th, his on-base percentage 60th, and his slugging percentage 106th.
• Willson Contreras has 123 hits and an OBP of .387, both of which lead the Red Sox this season.
• Contreras has logged a hit or more in two games in a row. During his last five outings he is batting .267 with a home run, two walks and two RBIs.
• Ceddanne Rafaela has an OPS of .763, fueled by an OBP of .319 and a team-best slugging percentage of .444 this season.
• Rafaela brings a two-game hitting streak into this matchup. In his last five games he is batting .267 with three RBIs.

Guardians Player Leaders

• Chase DeLauter has totaled 140 hits, a team-high for the Guardians. He's batting .290 and slugging .455 with an on-base percentage of .364.
• He is 11th in batting average, 20th in on-base percentage and 39th in slugging percentage among all qualifying batters in the majors.
• Steven Kwan's .379 OBP and .346 slugging percentage both pace his team. He has a batting average of .282.
• He is currently 19th in batting average, 10th in on-base percentage and 130th in slugging percentage among all qualifying hitters.
• Jose Ramirez has 27 doubles, 12 home runs and 59 walks while hitting .235.
• Brayan Rocchio is hitting .250 with 24 doubles, two triples, 13 home runs and 37 walks.

Red Sox vs Guardians Head to Head

• 9/23/2026: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/22/2026: 3-2 CLE (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/31/2026: 9-4 BOS (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/30/2026: 9-1 BOS (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/29/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/3/2025: 8-1 CLE (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/2/2025: 11-7 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/1/2025: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/27/2025: 13-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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