Red Sox vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 1:11 a.m.

The Boston Red Sox versus the Cleveland Guardians is on the MLB schedule for Wednesday.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Red Sox vs Guardians Game Info

• Boston Red Sox (84-73) vs. Cleveland Guardians (82-75)
• Date: Wednesday, September 23, 2026
• Time: 7:10 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: ESPN

Red Sox vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-134) | CLE: (+114)
• Spread: BOS: -1.5 (+168) | CLE: +1.5 (-205)
• Total: 7.5 -- Over: (+100) | Under: (-122)

Red Sox vs Guardians Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Red Sox) - 17-5, 2.82 ERA vs Foster Griffin (Guardians) - 15-5, 3.67 ERA

The Red Sox will give the ball to Sonny Gray (17-5, 2.82 ERA), who is eyeing win No. 18 on the season, and the Guardians will counter with Foster Griffin (15-5, 3.67 ERA). Gray's team is 17-10-0 against the spread this season in his starts. Gray's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 16-8. The Guardians have a 17-11-0 record against the spread in Griffin's starts. The Guardians have been the underdog on the moneyline in 17 of Griffin's starts this season, and they went 12-5 in those matchups.

Red Sox vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (59.5%)

Red Sox vs Guardians Moneyline

• The Red Sox vs Guardians moneyline has Boston as a -134 favorite, while Cleveland is a +114 underdog on the road.

Red Sox vs Guardians Spread

• The Red Sox are 1.5-run home favorites on the runline against the Guardians. The Red Sox are +168 to cover, and the Guardians are -205.

Red Sox vs Guardians Over/Under

• A total of 7.5 runs has been set for the Red Sox-Guardians game on Sept. 23, with the over available at +100 and the under at -122.

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Red Sox vs Guardians Betting Trends

• The Red Sox have been chosen as favorites in 107 games this year and have walked away with the win 58 times (54.2%) in those games.
• This season Boston has been victorious 31 times in 60 chances when named as a favorite of at least -134 on the moneyline.
• The Red Sox and their opponents have gone over in 68 of their 154 games with a total set by sportsbooks this season.
• The Red Sox have an against the spread mark of 73-81-0 in 154 games with a line this season.
• The Guardians have won 51.8% of the games this season they were the moneyline underdog (29-27).
• Cleveland has gone 16-12 when playing as a moneyline underdog with odds of +114 or longer (57.1%).
• The Guardians have played in 148 games with a set over/under, and have combined with opponents to go over the total 73 times (73-75-0).
• The Guardians have gone 70-78-0 ATS this season.

Red Sox Player Leaders

• Wilyer Abreu has 37 doubles, four triples, 24 home runs and 70 walks while batting .251. He has an on-base percentage of .331 and a slugging percentage of .453.
• He is 77th in batting average, 68th in on-base percentage, and 44th in slugging among qualifying batters in baseball.
• Caleb Durbin is hitting .254 with 25 doubles, a triple, 13 home runs and 50 walks. He's slugging .387 with an on-base percentage of .338.
• Among qualified hitters, he is 74th in batting average, 56th in on-base percentage and 102nd in slugging percentage.
• Willson Contreras leads his team in OBP (.387) and total hits (123) this season.
• Contreras enters this game with two games in a row with at least one hit. In his last five games he is batting .267 with a home run, two walks and two RBIs.
• Jarren Duran has 20 home runs, 69 RBI and a batting average of .204 this season.

Guardians Player Leaders

• Chase DeLauter has 140 hits, a team-best for the Guardians. He's batting .292 and slugging .459 with an on-base percentage of .367.
• Including all the qualified players in the majors, his batting average ranks ninth, his on-base percentage is 17th, and he is 37th in slugging.
• DeLauter takes a four-game hitting streak into this matchup. During his last five outings he is batting .333 with a double, a home run, three walks and three RBIs.
• Steven Kwan leads his team with a .378 on-base percentage, and has a club-leading .345 slugging percentage. He has a batting average of .280.
• He is currently 23rd in batting average, 10th in on-base percentage and 129th in slugging percentage among all qualifying hitters.
• Jose Ramirez has 27 doubles, 12 home runs and 58 walks while hitting .236.
• Brayan Rocchio has 24 doubles, two triples, 13 home runs and 37 walks while batting .250.

Red Sox vs Guardians Head to Head

• 9/22/2026: 3-2 CLE (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/31/2026: 9-4 BOS (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/30/2026: 9-1 BOS (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/29/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/3/2025: 8-1 CLE (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/2/2025: 11-7 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -270, Underdog Moneyline: +220)
• 9/1/2025: 6-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/27/2025: 13-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2025: 5-4 CLE (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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