Red Sox vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 2:13 a.m.

The Boston Red Sox are among the MLB squads busy on Wednesday, versus the Athletics.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's everything you need to know.

Red Sox vs Athletics Game Info

• Boston Red Sox (82-69) vs. Athletics (71-80)
• Date: Wednesday, September 17, 2025
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and NBCS-CA

Red Sox vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-184) | OAK: (+154)
• Spread: BOS: -1.5 (+106) | OAK: +1.5 (-128)
• Total: 9 -- Over: (-105) | Under: (-115)

Red Sox vs Athletics Probable Starting Pitchers

Probable Pitchers: Lucas Giolito (Red Sox) - 10-4, 3.31 ERA vs Mason Barnett (Athletics) - 1-1, 8.53 ERA

The probable pitchers are Lucas Giolito (10-4) for the Red Sox and Mason Barnett (1-1) for the Athletics. When Giolito starts, his team is 16-8-0 against the spread this season. Giolito's team has a record of 9-3 this season when he starts and they are the favorite on the moneyline. The Athletics have a 2-1-0 ATS record in Barnett's three starts with a set spread. The Athletics have been the moneyline underdog in three of Barnett's starts this season, and they went 2-1 in those matchups.

Red Sox vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (53%)

Red Sox vs Athletics Moneyline

• The Red Sox vs Athletics moneyline has the Red Sox as a -184 favorite, while the Athletics are a +154 underdog on the road.

Red Sox vs Athletics Spread

• The Red Sox are 1.5-run favorites on the runline against the Athletics. The Red Sox are +106 to cover, while the Athletics are -128 to cover.

Red Sox vs Athletics Over/Under

• A total of 9 runs has been set for the Red Sox-Athletics game on Sept. 17, with the over available at -105 and the under at -115.

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Red Sox vs Athletics Betting Trends

• The Red Sox have come away with 54 wins in the 94 contests they have been listed as the favorites in this season.
• This year, the Red Sox have won 12 of 16 games when listed as at least -184 or better on the moneyline.
• The Red Sox and their opponents have hit the over in 70 of their 150 games with a total this season.
• The Red Sox are 80-70-0 against the spread in their 150 games that had a posted line this season.
• The Athletics have won 52 of the 112 games they were the moneyline underdog this season (46.4%).
• When they have played as a moneyline underdog with odds of +154 or longer, the Athletics have gone 7-13 (35%).
• The Athletics have played in 150 games with a set over/under, and have combined with their opponents to go over the total 74 times (74-70-6).
• The Athletics have covered 53.3% of their games this season, going 80-70-0 ATS.

Red Sox Player Leaders

• Jarren Duran leads Boston in OBP (.334) and total hits (149) this season. He's batting .258 batting average while slugging .449.
• Among qualifying batters in MLB, his batting average ranks 74th, his on-base percentage ranks 63rd, and he is 59th in slugging.
• Duran will look for his fourth straight game with a hit in this contest. During his last five outings he is hitting .235 with a double, a triple, a home run, a walk and two RBIs.
• Trevor Story has hit 24 homers this season while driving in 91 runs. He's batting .265 this season and slugging .439 with an on-base percentage of .310.
• Among qualifying hitters, his batting average places him 47th, his on-base percentage 109th, and his slugging percentage 68th.
• Story brings a two-game streak with at least one hit into this one. In his last five games he is hitting .300 with a double and an RBI.
• Alex Bregman is batting .275 with a .470 slugging percentage and 59 RBI this year.
• Ceddanne Rafaela has been key for Boston with 121 hits, an OBP of .285 plus a slugging percentage of .403.

Athletics Player Leaders

• Brent Rooker has racked up a slugging percentage of .493, a team-best for the Athletics. He's batting .269 with an on-base percentage of .339.
• Including all the qualified hitters in the majors, he is 40th in batting average, 53rd in on-base percentage and 23rd in slugging percentage.
• Rooker heads into this matchup on a five-game hitting streak. In his last five games he is batting .400 with two doubles, two home runs, two walks and three RBIs.
• Tyler Soderstrom is hitting .278 with 31 doubles, a triple, 24 home runs and 52 walks. He's slugging .478 with an on-base percentage of .349.
• Including all qualified hitters, his batting average places him 25th, his on-base percentage is 39th, and he is 34th in slugging.
• Nick Kurtz is batting .296 with 24 doubles, two triples, 32 home runs and 59 walks.
• Shea Langeliers' 118 hits pace his team.

Red Sox vs Athletics Head to Head

• 9/16/2025: 2-1 OAK (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/10/2025: 5-4 OAK (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/9/2025: 6-0 BOS (Favorite: Athletics, Spread: -1.5, Total: 10.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/8/2025: 7-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/11/2024: 7-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 7/10/2024: 5-2 OAK (Favorite: Red Sox, Spread: -1.5, Total: 10, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 7/9/2024: 12-9 BOS (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/3/2024: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/2/2024: 5-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/1/2024: 9-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)

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