Rays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for ALCS Game 4 on Oct. 16

Odds updated as of 10:12 a.m.

In MLB action on Friday, the Tampa Bay Rays play the Cleveland Guardians in Game 4 of the ALCS.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Rays vs Guardians Game Info

• Tampa Bay Rays (98-64) vs. Cleveland Guardians (85-77)
• Date: Friday, October 16, 2026
• Time: 8 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: TBS, truTV, and HBO Max

Rays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-112) | CLE: (-104)
• Spread: TB: -1.5 (+168) | CLE: +1.5 (-205)
• Total: 6.5 -- Over: (-108) | Under: (-112)

Rays vs Guardians Probable Starting Pitchers

Probable Pitchers: Nick Martínez (Rays) - 15-6, 3.10 ERA vs TBA (Guardians)

The Rays will give the ball to Nick Martinez (15-6, 3.10 ERA), while the Guardians' starting pitcher has not yet been announced. Martinez and his team are 20-12-0 ATS this season when he starts. Martinez's team is 11-4 this season when he starts and they are the moneyline favorite.

Rays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (57.6%)

Rays vs Guardians Moneyline

• Tampa Bay is the favorite, -112 on the moneyline, while Cleveland is a -104 underdog despite being at home.

Rays vs Guardians Spread

• The Guardians are +1.5 on the spread (-205 to cover), and Tampa Bay is +168 to cover the runline.

Rays vs Guardians Over/Under

• The Rays-Guardians game on Oct. 16 has been given an over/under of 6.5 runs. The over is set at -108 and the under at -112.

Bet on Tampa Bay Rays vs. Cleveland Guardians on FanDuel today!

Rays vs Guardians Betting Trends

• The Rays have been favorites in 107 games this season and have come away with the win 68 times (63.6%) in those contests.
• This season Tampa Bay has been victorious 67 times in 104 chances when named as a favorite of at least -112 on the moneyline.
• The Rays and their opponents have hit the over in 77 of their 165 games with a total set by oddsmakers this season.
• The Rays are 88-77-0 against the spread in their 165 games with a line set by sportsbooks this season.
• The Guardians have a 32-30 record in games they were listed as the moneyline underdog (winning 51.6% of those games).
• When playing as a moneyline underdog with odds of -104 or longer, Cleveland has a 31-27 record (winning 53.4% of its games).
• The Guardians have played in 160 games with a set over/under, and have combined with their opponents to go over the total 78 times (78-82-0).
• The Guardians have a 77-83-0 record ATS this season (covering 48.1% of the time).

Rays Player Leaders

• Junior Caminero leads Tampa Bay with 170 hits, batting .276 this season with 68 extra-base hits. He has an on-base percentage of .360 and a slugging percentage of .524.
• Among all qualifying hitters in MLB, he is 33rd in batting average, 30th in on-base percentage, and sixth in slugging.
• Yandy Diaz has an OPS of .805, fueled by an OBP of .359 and a team-best slugging percentage of .446 this season. He's batting .293.
• Among qualified hitters, he ranks 10th in batting average, 33rd in on-base percentage and 50th in slugging percentage.
• Liam Hicks leads Tampa Bay with an OBP of .367 this season while batting .284 with 56 walks and 66 runs scored.
• Chandler Simpson has no home runs, but 38 RBI and a batting average of .306 this season.
• Simpson takes a two-game hitting streak into this game. During his last five outings he is batting .200 with a triple and three RBIs.

Guardians Player Leaders

• Chase DeLauter has put up 142 hits, a team-best for the Guardians. He's batting .287 and slugging .457 with an on-base percentage of .363.
• Including all the qualified players in the big leagues, his batting average is 16th, his on-base percentage is 24th, and he is 43rd in slugging.
• Steven Kwan has a .382 OBP while slugging .349. Both are team-highs. He has a batting average of .282.
• He ranks 21st in batting average, seventh in on-base percentage and 131st in slugging percentage in the big leagues.
• Jose Ramirez is hitting .235 with 27 doubles, 12 home runs and 60 walks.
• Brayan Rocchio has 25 doubles, two triples, 15 home runs and 38 walks while hitting .253.

Rays vs Guardians Head to Head

• 10/15/2026: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +112)
• 10/13/2026: 3-1 TB (Favorite: Rays, Spread: -1.5, Total: 6.5, Favorite Moneyline: -128, Underdog Moneyline: +114)
• 10/12/2026: 7-3 CLE (Favorite: Rays, Spread: -1.5, Total: 6.5, Favorite Moneyline: -166, Underdog Moneyline: +148)
• 7/26/2026: 1-0 TB (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/25/2026: 3-0 TB (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 11-3 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/28/2026: 1-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/27/2026: 3-2 TB (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/7/2025: 2-1 CLE (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/6/2025: 3-2 CLE (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)

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