Purdue vs Northwestern College Basketball Prediction, Odds, Picks, Best Bets for March 4

The Northwestern Wildcats (13-16, 5-13 Big Ten) will try to build on a three-game win streak when they host the Purdue Boilermakers (22-7, 12-6 Big Ten) on March 4, 2026 at Welsh-Ryan Arena.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Purdue vs. Northwestern Game Info and Odds

• Game day: Wednesday, March 4, 2026
• Game time: 8:30 p.m. ET
• TV channel: Big Ten Network
• Location: Evanston, Illinois
• Arena: Welsh-Ryan Arena

Purdue vs. Northwestern Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Purdue win (72.2%)

Here's a look at some betting trends for Purdue (-10.5) versus Northwestern on Wednesday. The over/under has been set at 146.5 points for this game.

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Purdue vs. Northwestern: ATS Betting Stats and Trends

• Purdue has compiled a 13-16-0 ATS record so far this year.
• Northwestern has won 11 games against the spread this year, while failing to cover 18 times.
• Purdue covers the spread when it is a 10.5-point favorite or more 46.7% of the time. That's less often than Northwestern covers as an underdog of 10.5 or more (60%).
• The Boilermakers have covered the spread in a lower percentage of their home games than road games. They have covered five times in 16 games when playing at home, and they've covered six times in 10 games on the road.
• The Wildcats' winning percentage against the spread at home is .333 (5-10-0). Away, it is .500 (5-5-0).
• Purdue is 7-11-0 against the spread in conference play this season.
• Northwestern's Big Ten record against the spread is 7-11-0.

Purdue vs. Northwestern: Moneyline Betting Stats

• Purdue has come away with 17 wins in the 23 contests it has been listed as the moneyline favorite in this season.
• The Boilermakers have yet to lose in 12 games when named as moneyline favorite of -671 or better.
• Northwestern has won 15.4% of the games this season it was the underdog on the moneyline (2-11).
• The Wildcats have not won a game when entering as a moneyline underdog with odds of +470 or longer in five chances.
• Purdue has an implied victory probability of 87% according to the moneyline set by sportsbooks for this matchup.

Purdue vs. Northwestern Head-to-Head Comparison

• Offensively, Purdue was the 82nd-ranked squad in the nation (77.3 points per game) last year. On defense, it was 126th (70.4 points conceded per game).
• Last year, Purdue was 300th in the country in rebounds (29.9 per game) and 28th in rebounds conceded (28.2).
• Purdue was 42nd in the nation in assists (15.9 per game) last season.
• Purdue committed 9.9 turnovers per game last year and forced 11.3 per game, ranking 62nd and 176th, respectively, in college basketball.
• Northwestern was 218th in the nation last season with 72.4 points per game. At the other end, it ranked 85th with 69.2 points allowed per contest.
• Northwestern ranked 266th in the nation with 30.6 rebounds per game. Meanwhile, it ranked 153rd with 30.8 rebounds allowed per game.
• Northwestern averaged 14.5 dimes per game, which ranked them 105th in the country.
• Northwestern ranked top-25 last year in turnovers, 25th-best in college basketball with 9.3 turnovers per game. Meanwhile, it ranked 67th with 12.6 forced turnovers per contest.

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